Genetic variants in ATP6 and ND3 mitochondrial genes are not associated with aggressive prostate cancer in Mexican–Mestizo men with overweight or obesity

Mitochondrial defects have been related to obesity and prostate cancer. We investigated if Mexican–Mestizo men presenting this type of cancer, exhibited somatic mutations of ATP6 and/or ND3.Body mass index (BMI) was determined; the degree of prostate cancer aggressiveness was demarcated by the Gleason score. DNA from tumor tissue and from blood leukocytes was amplified by the polymerase chain reaction and ATP6 and ND3 were sequenced. We included 77 men: 20 had normal BMI, 38 were overweight and 19 had obesity; ages ranged from 52 to 83. After sequencing ATP6 and ND3, from DNA obtained from leukocytes and tumor tissue, we did not find any somatic mutations. All changes observed, in both genes, were polymorphisms. In ATP6 we identified, in six patients, two non-synonymous nucleotide changes and in ND3 we observed that twelve patients presented non-synonymous polymorphisms. To our knowledge, this constitutes the first report where the complete sequences of the ATP6 and ND3 have been analyzed in Mexican–Mestizo men with prostate cancer and diverse BMI. Our results differ with those reported in Caucasian populations, possibly due to ethnic differences.     

后新公共管理时代的跨部门协同——评希克斯的整体政府理论

希克斯的整体政府理论既是对功能性组织模型进行反思与批判的产物,也是对新公共管理理论难以应对社会管理和公共服务需求日趋复杂化所产生的协同问题的一种直接回应。希克斯的整体政府理论形成了一种以跨部门协同为基本特征的系统化理论体系,其发展前景表现为宏观层面治理整合的整体治理与微观层面管理协作的网络管理。客观地评价希克斯的整体政府理论,对我国政府改革的理论与实践具有重要的参考价值。     

提高英语阅读理解能力的方法

本文分析了英语语篇的模式、形式、写作类型及文章结构的各种类型 ,总结了作者多年来的教学经验 ,论述了引导学生提高英语阅读能力的方法     

痕量银(Ⅰ)的催化显色分光光度法测定

本文研究了银(Ⅰ)对亚铁氰化钾与邻菲罗啉(O-phen)显色反应的催化效应.以此为基础,建立了痕量银(Ⅰ)的催化分光光度分析法.本法的灵敏度为1.0×10~(-3)μg/mL,线性范围为0～4μg/25mL,用于水样中痕量银(Ⅰ)的测定.     

ZnO电压敏陶瓷中偏锑酸钡相含量与电性能关系的研究

研究了偏锑酸钡相（BaSb2O6)的含量和ZnO电压敏陶瓷电性能和关系。结果表明，在偏酸钡相，锌锑尖晶石相和氧化铋相三种晶相的总和中，过少或过多的偏锑酸钡相不能使ZnO电压敏陶瓷具有优良的综合性能，其较佳的范围在10％－35％。     

论当代先进管理模式——六西格玛管理

六西格玛管理是美国摩托罗拉公司(MOTOROLA)于20世纪80年代所发明的先进管理模式,在世界许多著名公司获得成功,并成为世界级公司的重要标志。本文论述了六西格玛管理的理念、方法、程序、国外成功的经验以及六西格玛管理与全面质量管理和ISO9000质量管理体系的关系。     

Analysis of an addictions treatment system

A treatment system consisting of an assessment/referral service, a detox, a mission, a hospital recovery unit, and three recovery homes was examined using a retrospective client-tracking approach over 1 year. There were 4,187 admissions to the system accounted for by 1,522 individuals; system users tended to be males, unmarried, unemployed, and in their 30s and 40s. The best predictor of readmission to the system after treatment was prior system use. Use patterns and referral data indicated that perceived gatekeepers (i.e., detoxication and assessment services) were not consistently coordinating the system and that more socially stable clients appeared to be more likely to be involved with non-addiction specific services (i.e., medical, general counselling).     

"指事"新解

"指事"为许慎所列的"六书"之首,是历代学者划分汉字结构时产生问题最多的一书.通过对许慎所作的"六书"义例和汉代三家所列"六书"名目的研究,我们将"指事"的"指"字破译为"稽"字,将"指事"解读为"审察事物"的意思;并通过运用新见解说近十个典型的指事字,使"指示符号"的成说也得以彻底否定.     

4-6岁儿童对不同面部表情识别的眼动特征分析

：使用眼动技术,通过记录和分析88名4-6岁儿童对不同强度表情识别的成绩表现及眼动数据,探讨儿童识别不同强度表情的即时加工过程、发展状况及眼动模式,并在划分兴趣区的基础上,对不同强度表情识别过程中不同部位的优势效应进行分析。结果发现：（1）4-6岁儿童对不同强度表情的识别成绩随着表情强度增加而提高;（2）4-6岁儿童对不同强度表情的注视时间和注视次数随表情强度的增加而减少;（3）随着表情强度的增加,面部不同部位的作用会有所改变,如愉快表情的嘴部越来越重要,愤怒表情的眉眼部越来越重要。