Correlation estimation in Downton's bivariate exponential distribution using incomplete samples

Suppose (X, Y) has a Downton's bivariate exponential distribution with correlation ρ. For a random sample of size n from (X, Y), let X _r:n be the rth X-order statistic and Y _[r:n] be its concomitant. We investigate estimators of ρ when all the parameters are unknown and the available data is an incomplete bivariate sample made up of (i) all the Y-values and the ranks of associated X-values, i.e. (i, Y _[i:n]), 1≤i≤n, and (ii) a Type II right-censored bivariate sample consisting of (X _i:n , Y _[i:n]), 1≤i≤r<n. In both setups, we use simulation to examine the bias and mean square errors of several estimators of ρ and obtain their estimated relative efficiencies. The preferred estimator under (i) is a function of the sample correlation of (Y _i:n , Y _[i:n]) values, and under (ii), a method of moments estimator involving the regression function is preferred.     

Pitman closeness,monotonicity and consistency of best linear unbiased and invariant estimators for exponential distribution under Type II censoring

Comparisons of best linear unbiased estimators with some other prominent estimators have been carried out over the last 50 years since the ground breaking work of Lloyd [E.H. Lloyd, Least squares estimation of location and scale parameters using order statistics, Biometrika 39 (1952), pp. 88–95]. These comparisons have been made under many different criteria across different parametric families of distributions. A noteworthy one is by Nagaraja [H.N. Nagaraja, Comparison of estimators and predictors from two-parameter exponential distribution, Sankhyā Ser. B 48 (1986), pp. 10–18], who made a comparison of best linear unbiased (BLUE) and best linear invariant (BLIE) estimators in the case of exponential distribution. In this paper, continuing along the same lines by assuming a Type II right censored sample from a scaled-exponential distribution, we first compare BLUE and BLIE of the exponential mean parameter in terms of Pitman closeness (nearness) criterion. We show that the BLUE is always Pitman closer than the BLIE. Next, we introduce the notions of Pitman monotonicity and Pitman consistency, and then establish that both BLUE and BLIE possess these two properties.     

Bayesian estimation and prediction for Weibull model with progressive censoring

This article presents the statistical inferences on Weibull parameters with the data that are progressively type II censored. The maximum likelihood estimators are derived. For incorporation of previous information with current data, the Bayesian approach is considered. We obtain the Bayes estimators under squared error loss with a bivariate prior distribution, and derive the credible intervals for the parameters of Weibull distribution. Also, the Bayes prediction intervals for future observations are obtained in the one- and two-sample cases. The method is shown to be practical, although a computer program is required for its implementation. A numerical example is presented for illustration and some simulation study are performed.     

Adaptive designs for single‐arm phase II trials in oncology

Clinical phase II trials in oncology are conducted to determine whether the activity of a new anticancer treatment is promising enough to merit further investigation. Two‐stage designs are commonly used for this situation to allow for early termination. Designs proposed in the literature so far have the common drawback that the sample sizes for the two stages have to be specified in the protocol and have to be adhered to strictly during the course of the trial. As a consequence, designs that allow a higher extent of flexibility are desirable. In this article, we propose a new adaptive method that allows an arbitrary modification of the sample size of the second stage using the results of the interim analysis or external information while controlling the type I error rate. If the sample size is not changed during the trial, the proposed design shows very similar characteristics to the optimal two‐stage design proposed by Chang et al. (Biometrics 1987; 43:865–874). However, the new design allows the use of mid‐course information for the planning of the second stage, thus meeting practical requirements when performing clinical phase II trials in oncology. Copyright © 2012 John Wiley & Sons, Ltd.     

A Hybrid Geometric Phase II/III Clinical Trial Design based on Treatment Failure Time and Toxicity

The problem of comparing several experimental treatments to a standard arises frequently in medical research. Various multi-stage randomized phase II/III designs have been proposed that select one or more promising experimental treatments and compare them to the standard while controlling overall Type I and Type II error rates. This paper addresses phase II/III settings where the joint goals are to increase the average time to treatment failure and control the probability of toxicity while accounting for patient heterogeneity. We are motivated by the desire to construct a feasible design for a trial of four chemotherapy combinations for treating a family of rare pediatric brain tumors. We present a hybrid two-stage design based on two-dimensional treatment effect parameters. A targeted parameter set is constructed from elicited parameter pairs considered to be equally desirable. Bayesian regression models for failure time and the probability of toxicity as functions of treatment and prognostic covariates are used to define two-dimensional covariate-adjusted treatment effect parameter sets. Decisions at each stage of the trial are based on the ratio of posterior probabilities of the alternative and null covariate-adjusted parameter sets. Design parameters are chosen to minimize expected sample size subject to frequentist error constraints. The design is illustrated by application to the brain tumor trial.     

Adaptive Isotonic Estimation of the Minimum Effective and Peak Doses in the Presence of Covariates

We consider a problem of estimating the minimum effective and peak doses in the presence of covariates. We propose a sequential strategy for subject assignment that includes an adaptive randomization component to balance the allocation to placebo and active doses with respect to covariates. We conclude that either adjusting for covariates in the model or balancing allocation with respect to covariates is required to avoid bias in the target dose estimation. We also compute optimal allocation to estimate the minimum effective and peak doses in discrete dose space using isotonic regression.     

Empirical Non-Parametric Control Charts: Estimation Effects and Corrections

Owing to the extreme quantiles involved, standard control charts are very sensitive to the effects of parameter estimation and non-normality. More general parametric charts have been devised to deal with the latter complication and corrections have been derived to compensate for the estimation step, both under normal and parametric models. The resulting procedures offer a satisfactory solution over a broad range of underlying distributions. However, situations do occur where even such a large model is inadequate and nothing remains but to consider non- parametric charts. In principle, these form ideal solutions, but the problem is that huge sample sizes are required for the estimation step. Otherwise the resulting stochastic error is so large that the chart is very unstable, a disadvantage that seems to outweigh the advantage of avoiding the model error from the parametric case. Here we analyse under what conditions non-parametric charts actually become feasible alternatives for their parametric counterparts. In particular, corrected versions are suggested for which a possible change point is reached at sample sizes that are markedly less huge (but still larger than the customary range). These corrections serve to control the behaviour during in-control (markedly wrong outcomes of the estimates only occur sufficiently rarely). The price for this protection will clearly be some loss of detection power during out-of-control. A change point comes in view as soon as this loss can be made sufficiently small.     

Balanced and partially balanced incomplete block designs with autocorrelation errors

The paper aims to find variance balanced and variance partially balanced incomplete block designs when observations within blocks are autocorrelated and we call them BIBAC and PBIBAC designs. Orthogonal arrays of type I and type II when used as BIBAC designs have smaller average variance of elementary contrasts of treatment effects compared to the corresponding Balanced Incomplete Block (BIB) designs with homoscedastic, uncorrelated errors. The relative efficiency of BIB designs compared to BIBAC designs depends on the block size k and the autocorrelation ρ and is independent of the number of treatments. Further this relative efficiency increases with increasing k. Partially balanced incomplete block designs with autocorrelated errors are introduced using partially balanced incomplete block designs and orthogonal arrays of type I and type II.     

CRTSⅡ型轨道板翻转机主梁结构的有限元分析

通过研究CRTSⅡ型轨道板翻转机的翻转过程,结合传统翻转机的翻转过程,对传统翻转机的主梁结构进行改进。改进后的翻转机主梁采用箱式结构,这种主梁结构更紧凑,并且容易加工。对改进的翻转机主梁结构进行有限元分析,结果表明,改进后的箱式主梁结构满足强度和稳定性要求,可以实现在翻转过程中结构稳定,为主梁结构的优化设计提供依据。     

西班牙法西斯政权的建立及在二战中保持中立的原因

西班牙在一战后二战前建立起了法西斯独裁统治的国家。德、意、日三国结为轴心国在二战中犯下了滔天罪行,然而同为法西斯国家的西班牙却在这场全球三分之二的国家被卷入的世界大战中保持中立,让史学界和国际关系学界诸多学者难以理解。阐述了西班牙内战的经过、结局和影响,在此基础上,探析了西班牙内战的前因后果与佛朗哥法西斯政权在二战中保持中立的原因。