A note on robustness of D-optimal block designs for two-colour microarray experiments

Two-colour microarray experiments form an important tool in gene expression analysis. Due to the high risk of missing observations in microarray experiments, it is fundamental to concentrate not only on optimal designs but also on designs which are robust against missing observations. As an extension of Latif et al. (2009), we define the optimal breakdown number for a collection of designs to describe the robustness, and we calculate the breakdown number for various D-optimal block designs. We show that, for certain values of the numbers of treatments and arrays, the designs which are D-optimal have the highest breakdown number. Our calculations use methods from graph theory.     

Consistency of maximum likelihood estimators in a large class of deconvolution models

We consider the maximum likelihood estimator $\hat{F}_n$ of a distribution function in a class of deconvolution models where the known density of the noise variable is of bounded variation. This class of noise densities contains in particular bounded, decreasing densities. The estimator $\hat{F}_n$ is defined, characterized in terms of Fenchel optimality conditions and computed. Under appropriate conditions, various consistency results for $\hat{F}_n$ are derived, including uniform strong consistency. The Canadian Journal of Statistics 41: 98–110; 2013 © 2012 Statistical Society of Canada     

基于核和灰度的双重异构数据序列预测建模方法研究

通过建立灰色异构数据"核"序列的DGM(1,1)模型,实现双重异构数据"核"的预测;以"核"为基础、以双重异构数据序列中较大的区间灰数信息域作为预测结果的信息域,构建基于区间灰数与实数的双重异构数据序列灰色预测模型,有效地将灰色预测模型建模对象从"同质数据"拓展至"双重异构数据"。研究成果对丰富灰色预测模型理论体系具有积极意义。     

Extended generalised Pareto models for tail estimation

The most popular approach in extreme value statistics is the modelling of threshold exceedances using the asymptotically motivated generalised Pareto distribution. This approach involves the selection of a high threshold above which the model fits the data well. Sometimes, few observations of a measurement process might be recorded in applications and so selecting a high quantile of the sample as the threshold leads to almost no exceedances. In this paper we propose extensions of the generalised Pareto distribution that incorporate an additional shape parameter while keeping the tail behaviour unaffected. The inclusion of this parameter offers additional structure for the main body of the distribution, improves the stability of the modified scale, tail index and return level estimates to threshold choice and allows a lower threshold to be selected. We illustrate the benefits of the proposed models with a simulation study and two case studies.     

An efficient sequential design of clinical trials

We propose an efficient group sequential monitoring rule for clinical trials. At each interim analysis both efficacy and futility are evaluated through a specified loss structure together with the predicted power. The proposed design is robust to a wide range of priors, and achieves the specified power with a saving of sample size compared to existing adaptive designs. A method is also proposed to obtain a reduced-bias estimator of treatment difference for the proposed design. The new approaches hold great potential for efficiently selecting a more effective treatment in comparative trials. Operating characteristics are evaluated and compared with other group sequential designs in empirical studies. An example is provided to illustrate the application of the method.     

精算思想的演进与精算理论发展综述

精算是保险发展的基础,是保险经营的技术支持。精算在国外有四百年的发展历史,引入中国只有二十年。要使精算技术在中国得到发展创新并为社会需要服务,必须了解精算思想产生的历史背景,厘清精算理论发展的脉络,真正把握精算思想的实质。基于此,介绍了精算各发展时期的主要代表人物及其学术思想,阐述精算技术对各时期保险发展的影响,同时对精算学与复利理论、数学、统计学、计算技术、金融经济学交叉融合的历史过程进行了分析述评。     

基于改进D—S证据理论的TOPSIS模型在科技奖励评价中的应用

针对科技奖励评价的特点,根据改进D—S证据合成规则,将专家的评价指标值转化为指标的综合得分并形成决策矩阵;结合TOPSIS模型求解理想解和负理想解,计算距离和贴近度,对各评价项目进行综合排名。实证结果表明：该模型能够很好地解决科技奖励评价过程中的不确定性问题,为科技奖励综合评价提供了一种新的思路。     

On optimising the estimation of high quantiles of a probability distribution

One of the major aims of one-dimensional extreme-value theory is to estimate quantiles outside the sample or at the boundary of the sample. The underlying idea of any method to do this is to estimate a quantile well inside the sample but near the boundary and then to shift it somehow to the right place. The choice of this “anchor quantile” plays a major role in the accuracy of the method. We present a bootstrap method to achieve the optimal choice of sample fraction in the estimation of either high quantile or endpoint estimation which extends earlier results by Hall and Weissman (1997) in the case of high quantile estimation. We give detailed results for the estimators used by Dekkers et al. (1989). An alternative way of attacking problems like this one is given in a paper by Drees and Kaufmann (1998).     

R–estimation of normed bivariate density functions

Normed bivariate density funtions were introduced by HOEFFDING (1940/41). In the present paper estimators for normed bivariate ranks and on a FOURIER series expansion in LEGENDRE polynomials. The estimation of normed bivarate density functions under positive dependence is also described     

CUSUM Hypothesis Tests and Alternative Response Probabilities for Finite Poisson Trials

This article develops a new cumulative sum statistic to identify aberrant behavior in a sequentially administered multiple-choice standardized examination. The examination responses can be described as finite Poisson trials, and the statistic can be used for other applications which fit this framework. The standardized examination setting uses a maximum likelihood estimate of examinee ability and an item response theory model. Aberrant and non aberrant probabilities are computed by an odds ratio analogous to risk adjusted CUSUM schemes. The significance level of a hypothesis test, where the null hypothesis is non-aberrant examinee behavior, is computed with Markov chains. A smoothing process is used to spread probabilities across the Markov states. The practicality of the approach to detect aberrant examinee behavior is demonstrated with results from both simulated and empirical data.