Comparing two measures of creatinine clearance: an application of errors-in-variables and bootstrap techniques

Two indices of creatinine clearance (an index of kidney function) are compared on a group of cancer patients who underwent chemotherapy with a potentially nephrotoxic drug. The standard index, measured creatinine clearance MCC, is cumbersome to use, whereas the more convenient alternative, estimated creatinine clearance ECC, has not yet been conclusively evaluated on cancer patients. We conclude that under certain clinical conditions ECC and MCC are identically calibrated for males, but not for females, and we obtain estimated true and false positive rates for assessing the use of ECC instead of MCC as a diagnostic tool. We use a model that is formally equivalent to an errors-in-variables model with (unbalanced) repeated observations and correlated measurement errors. The bootstrap is used to obtain standard errors and confidence limits.     

Analyzing Supersaturated Designs by Means of an Information Based Criterion

The cost and time consumption of many industrial experimentations can be reduced using the class of supersaturated designs since this can be used for screening out the important factors from a large set of potentially active variables. A supersaturated design is a design for which there are fewer runs than effects to be estimated. Although there exists a wide study of construction methods for supersaturated designs, their analysis methods are yet in an early research stage. In this article, we propose a method for analyzing data using a correlation-based measure, named as symmetrical uncertainty. This method combines measures from the information theory field and is used as the main idea of variable selection algorithms developed in data mining. In this work, the symmetrical uncertainty is used from another viewpoint in order to determine more directly the important factors. The specific method enables us to use supersaturated designs for analyzing data of generalized linear models for a Bernoulli response. We evaluate our method by using some of the existing supersaturated designs, obtained according to methods proposed by Tang and Wu (1997 Tang , B. , Wu , C. F. J. (1997). A method for constructing supersaturated designs and its E(s ²)-optimality. Canadian Journal of Statistics 25:191–201.[Crossref], [Web of Science ®] , [Google Scholar]) as well as by Koukouvinos et al. (2008 Koukouvinos , C. , Mylona , K. , Simos , D. E. ( 2008 ). E(s ²)-optimal and minimax-optimal cyclic supersaturated designs via multi-objective simulated annealing . Journal of Statistical Planning and Inference 138 : 1639 – 1646 .[Crossref], [Web of Science ®] , [Google Scholar]). The comparison is performed by some simulating experiments and the Type I and Type II error rates are calculated. Additionally, Receiver Operating Characteristics (ROC) curves methodology is applied as an additional statistical tool for performance evaluation.     

Moments of suprema of random variables

The supremum of random variables representing a sequence of rewards is of interest in establishing the existence of optimal stopping rules. Necessary and sufficient conditions are given for existence of moments of sup_n(X_n ? c_n) and sup_n(S_n ? c_n) where X₁, X₂, … are i.i.d. random variables, S_n = X₁ + … + X_n, and c_n = (nL(n))^1/r, 0 < r < 2, L = 1, L = log, and L = log log. Following Cohn (1974), “rates of convergence” results are used in the proof.     

New approximate confidence intervals for the difference between two Poisson means and comparison

The problem of estimating the difference between two Poisson means is considered. A new moment confidence interval (CI), and a fiducial CI for the difference between the means are proposed. The moment CI is simple to compute, and it specializes to the classical Wald CI when the sample sizes are equal. Numerical studies indicate that the moment CI offers improvement over the Wald CI when the sample sizes are different. Exact properties of the CIs based on the moment, fiducial and hybrid methods are evaluated numerically. Our numerical study indicates that the hybrid and fiducial CIs are in general comparable, and the moment CI seems to be the best when the expected total counts from both distributions are two or more. The interval estimation procedures are illustrated using two examples.     

Positive False Discovery Rate Estimate in Step-Wise Variable Selection

Selecting predictors to optimize the outcome prediction is an important statistical method. However, it usually ignores the false positives in the selected predictors. In this article, we advocate a conventional stepwise forward variable selection method based on the predicted residual sum of squares, and develop a positive false discovery rate (pFDR) estimate for the selected predictor subset, and a local pFDR estimate to prioritize the selected predictors. This pFDR estimate takes account of the existence of non null predictors, and is proved to be asymptotically conservative. In addition, we propose two views of a variable selection process: an overall and an individual test. An interesting feature of the overall test is that its power of selecting non null predictors increases with the proportion of non null predictors among all candidate predictors. Data analysis is illustrated with an example, in which genetic and clinical predictors were selected to predict the cholesterol level change after four months of tamoxifen treatment, and pFDR was estimated. Our method's performance is evaluated through statistical simulations.     

A Distribution-Free Control Chart Based on Order Statistics

In this article, we introduce a new distribution-free Shewhart-type control chart that takes into account the location of a single order statistic of the test sample (such as the median) as well as the number of observations in that test sample that lie between the control limits. Exact formulae for the alarm rate, the run length distribution, and the average run length (ARL) are all derived. A key advantage of the chart is that, due to its nonparametric nature, the false alarm rate and in-control run length distribution are the same for all continuous process distributions, and so will be naturally robust. Tables are provided for the implementation of the chart for some typical ARL values and false alarm rates. The empirical study carried out reveals that the new chart is preferable from a robustness point of view in comparison to a classical Shewhart-type chart and also the nonparametric chart of Chakraborti et al. (2004 Chakraborti , S. , van der Laan , P. , van de Wiel , M. A. ( 2004 ). A class of distribution-free control charts . J. Roy. Statist. Soc. Ser. C-Appl. Statist. 53 ( 3 ): 443 – 462 .[Web of Science ®] , [Google Scholar]).     

Dirichlet models for square contingency tables

We consider the square contingency tables which arise when the same method of classification is applied twice. The hypothesis of marginal homogeneity is then relevant! and can be tested by various methods Models are discussed which contain marginal homogeneity as a special case. They include a class based on univariate and bivariate Dirichlet distributions. The question of ordered categories is briefly discussed. Applications are made to data on unaided distance vision.     

The maximum likelihood estimators of the parameters of the gamma distribution are always positively biased

Several authors have conjectured, on the basis of their numerical work, that the maximum likelihood estimators of the shape and scale parameters of the Gamma distribution are positively biased. It is proved that their conjecture is always true.     

A multiple model discrimination procedure

The case of selecting between a set of fixed models is considered. The true model is assumed to be contained in the set of proposed models and errors are taken to be normally distributed. A sequential procedure which yeilds probabilities of incorrect selections is proposed. The procedure is shown to have optimal properties and is extended to the estimated model case by a bootstrap procedure.