Research Subject Advocate: A New Protector of Research Participants

In 2001, the National Center for Research Resources (NCRR) directed the 78 General Clinical Research Centers (GCRC) to develop a Research Subject Advocate (RSA) position. The RSA would report directly to the Principal Investigator (PI) of each GCRC and assure compliance of studies conducted on the GCRC with federal regulations and policies. Seven RSAs agreed to be interviewed about their new role. Website documents, electronic correspondence, and presentations at the first annual national meeting of RSAs were scrutinized using discursive analysis to shed light on this new organizational form and its potential for increased protection of human research participants. The RSA role actualizes the ethical principles of respect for persons, justice, and beneficence that are the foundation of the protection of research participants. The results also reveal the regulatory, institutional, collegial, and personal resources and barriers that assist the RSA in the successful implementation of the RSA role. In addition, issues important to the RSAs are described.     

论《潮水集》跨文体写作的艺术张力

散文集《潮水集》的跨文体写作主要表现在两个方面：一是文史交融，作者建构了一个三维情感世界，使作品在文学与历史中穿行；二是均衡之美，表现在“叙事一抒情一叙事”和“议论一抒情一议论”两个创作模式上。     

Understanding Canonical Correlation through the General Linear Model and Principal Components

Canonical correlation has been little used and little understood, even by otherwise sophisticated analysts. An alternative approach to canonical correlation, based on a general linear multivariate model, is presented. Properties of principal component analysis are used to help explain the method. Standard computational methods for full rank canonical correlation, techniques for canonical correlation on component scores, and canonical correlation with less than full rank are discussed. They are seen to be essentially equivalent when the model equation for canonical correlation on component scores is presented. The two approaches to less than full rank situations are equivalent in some senses, but quite different in usefulness, depending on the application. An example dataset is analyzed in detail to help demonstrate the conclusions.     

农村社会生态理性的社会学研究

本文从理性视角构筑认识论框架,在此框架内对环境价值作出评估。在肯定理性多样化并存的前提下,把两个最具争议的理性——经济理性与生态理性并列齐观,以阐明二者在环境问题上的分歧,并从中揭示出中心价值对边陲价值的侵犯,并以政治形式将其合法化、正当化的过程。如何实现经济理性与生态理性的和解,宏观层面需要工业文明向生态文明的转变,微观层面需要从＂以人为中心＂的价值观向＂人与环境和谐共处＂的价值观转向,在这一转向过程中经济理性与生态理性相平衡的价值观教育是很有必要的。     

Effects of Alternative Policies on Income Redistribution: Evidence from Brazil

Despite recent successes, Brazilian income (cash) transfer policies remain controversial, and alternative approaches to income redistribution are being actively considered. This article contributes to this debate, analysing the effects of several alternative policies for income redistribution in the Brazilian economy using a computable general equilibrium model. Simulations were conducted consistent with the following policies: direct transfer of income, reduction of taxes, and incentives to agricultural exports. The results suggest that transfer of income is the most effective in promoting redistribution of income, with a positive impact on the level of welfare of the poorest households.     

Analysis of all-zero binomial outcomes with borderline and equilibrium priors

This article is concerned with the analysis of a random sample from a binomial distribution when all the outcomes are zero (or unity). We discuss how elicitation of the prior can be reduced to asking the expert whether (and which of) the so-called borderline or equilibrium priors are plausible.     

德沃金的建构性解释与反思平衡

“反思平衡”是一种道德原则或道德理论的证立方法,其具体过程可以分为四个阶段.反思平衡包括狭窄的反思平衡和宽泛的反思平衡,二者追求的目标分别是局部融贯和整体融贯.德沃金的“建构性解释”方法是反思平衡在法理学中的应用.建构性解释中的“符合”和“最佳”维度分别体现了狭窄的反思平衡和宽泛的反思平衡的要求.     

个人选择与政府选择的制度平衡

中国近几十年的经济发展与个人选择权的增加和政府控制的减少有很大关系,而目前两者之间相互调整的不到位是一些深层次社会结构性矛盾产生的主要原因。在全球化背景下,如何立足中国的现实环境,探讨中国长治久安、和谐发展的社会制度安排,尤其是个人选择与政府选择之间的制度平衡,是一个重要的理论和实践课题。     

Case–control genome-wide joint association study using semiparametric empirical model and approximate Bayes factor

We propose a semiparametric approach for the analysis of case–control genome-wide association study. Parametric components are used to model both the conditional distribution of the case status given the covariates and the distribution of genotype counts, whereas the distribution of the covariates are modelled nonparametrically. This yields a direct and joint modelling of the case status, covariates and genotype counts, and gives a better understanding of the disease mechanism and results in more reliable conclusions. Side information, such as the disease prevalence, can be conveniently incorporated into the model by an empirical likelihood approach and leads to more efficient estimates and a powerful test in the detection of disease-associated SNPs. Profiling is used to eliminate a nuisance nonparametric component, and the resulting profile empirical likelihood estimates are shown to be consistent and asymptotically normal. For the hypothesis test on disease association, we apply the approximate Bayes factor (ABF) which is computationally simple and most desirable in genome-wide association studies where hundreds of thousands to a million genetic markers are tested. We treat the approximate Bayes factor as a hybrid Bayes factor which replaces the full data by the maximum likelihood estimates of the parameters of interest in the full model and derive it under a general setting. The deviation from Hardy–Weinberg Equilibrium (HWE) is also taken into account and the ABF for HWE using cases is shown to provide evidence of association between a disease and a genetic marker. Simulation studies and an application are further provided to illustrate the utility of the proposed methodology.     

职业道德建设与我国卫生体制改革

本文根据<公民道德建设实施纲要>关于职业道德的基本要求,结合卫生行业实际,提出了卫生行业各部门工作人员应遵循的具体职业道德要求,并就如何通过卫生体制改革促进卫生职业道德建设提出了自己的见解.