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22.
Peter B. Gilbert 《Journal of the Royal Statistical Society. Series C, Applied statistics》2005,54(1):143-158
Summary. To help to design vaccines for acquired immune deficiency syndrome that protect broadly against many genetic variants of the human immunodeficiency virus, the mutation rates at 118 positions in HIV amino-acid sequences of subtype C versus those of subtype B were compared. The false discovery rate (FDR) multiple-comparisons procedure can be used to determine statistical significance. When the test statistics have discrete distributions, the FDR procedure can be made more powerful by a simple modification. The paper develops a modified FDR procedure for discrete data and applies it to the human immunodeficiency virus data. The new procedure detects 15 positions with significantly different mutation rates compared with 11 that are detected by the original FDR method. Simulations delineate conditions under which the modified FDR procedure confers large gains in power over the original technique. In general FDR adjustment methods can be improved for discrete data by incorporating the modification proposed. 相似文献
23.
国内外公共突发事件应对研究述评 总被引:3,自引:0,他引:3
苗兴壮 《广东培正学院学报》2006,(1)
本文分别回顾了中外有关社会公共突发事件应急和企业危机管理的研究过程,从纷繁的研究文献中概括了有关突发事件应急的研究框架,认为对突发事件应急的研究可以归纳为静态系统和动态过程两个方面。近十几年来的研究重点主要放在了动态过程的研究上,而对静态系统的研究相对比较薄弱。 相似文献
24.
从"全能政府"到"无为而治"--论现代城市管理理念的转变 总被引:1,自引:0,他引:1
章仁彪 《同济大学学报(社会科学版)》2002,13(3):37-43
城市化的质的规定性要求城市管理理念的创新。现代城市“管理”的多义性与城市政府职能的转换密切相关。从“全能政府”向“有限政府”的转换是市场经济发展的必然。现代城市管理中的“善治”应是强化政府公共行政管理职能与扩大城市管理市场化改革的统一。“无为而治”是以“无为”之形而行“有治”之实 ,是“依法治市”和“以德治市”的统一 相似文献
25.
通过对我国现行管理会计教材质量总体状况的调查分析,表明我国管理会计教材理论脱离实际,没有建立有中国特色的管理会计理论体系。研究认为,改变目前落后状况的关键在于加强我国管理会计典型案例的研究。 相似文献
26.
楚光玉 《渤海大学学报(哲学社会科学版)》2006,28(1):49-54
人学是关于人的存在、本质及其产生、运动、发展、变化规律的新兴科学。人学首先以人自身为研究对象,并将人纳入自然界和宇宙之中予以通观。人是肉体和精神的物质辩证统一体,精神的实质也是物质。人与自然界物质存在形态在根本上是一致的,人与宇宙在本质上是同一的。人生的意义和价值存在于为他人、为社会、为人类做出的贡献之中。正确的宇宙观、人生观、价值观、时空观和发展观的确立,将会使人走上真正彻底自由和解放的道路。 相似文献
27.
Research on firm search stresses the need for firms to adapt and align concurrently with their environment to optimize the ability to sense and seize opportunities for sustained performance. We postulate resource scarcity as an important contingency factor for the search-performance relationship, and assess its joint influence with high and low dynamism. Using a dataset spanning 23 years, we examine the performance implications of combinations of internal and external exploratory and exploitative search in resource-scarce environments, under conditions of high and low dynamism. We find that resource scarcity is an important condition for performance stemming from exploratory and exploitative search: even under conditions that involve low dynamism, but joined with resource scarcity, firms may benefit from pursuing exploratory and exploitative knowledge simultaneously. 相似文献
28.
Flora L. Williams 《Journal of Family and Economic Issues》1991,12(3):235-252
This study explores differences in inter-household exchange of goods and services in Anglo- and Mexican-American families controlling for income level and for ethnicity. The extent of such exchange, its perceived importance to the family's quality of life, satisfaction with the exchange, and the relation of persons in the exchange process are examined. Significant differences are found more often between higher income Anglo- and Mexican-Americans than between low-income families, both in the family providing goods and services for others and in the receipt of them. Higher income Mexican-American families are more likely than their Anglo- counterparts to exchange with relatives. Ethnic effects are more prevalent in higher income households than in low-income households. Economic effects are more predominant than ethnic effects.This study contributes to interregional Agricultural Experiment Station Research Project NC-128, Quality of Life as Influenced by Area of Residence. Cooperating states: Arizona, California, Colorado, Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, Nevada, Ohio, Texas.Flora L. Williams' current research interests include income adequacy, financial problems, and indicators of change in economic well-being. She is an Associate Professor, Consumer Sciences and Retailing, Purdue University, West Lafayette, IN 47907. 相似文献
29.
徐长醒 《南京人口管理干部学院学报》1998,14(3):36-40
本文分析了微机DBMS———FoxPro2.5的特点及其在开发应用系统的优势和不足,介绍了独立实现的计划生育管理信息系统,还就应用系统的实现方式,对比了事件驱动方式与传统的菜单驱动方式 相似文献
30.
Institutional Ethnography and Experience as Data 总被引:1,自引:0,他引:1
Experience, as concept, is contested among feminists as to its epistemological status, thus its usefulness in knowledge claims. Institutional ethnography (Smith 1987) is a feminist methodology that nonetheless relies fundamentally on people's experience. Not as Truth, nor the object of inquiry, but as thepoint d'appui for sociological inquiry. This article offers a demonstration of institutional enthnography using observational and interview data that show experience as methodologically central to a trustworthy analysis. A moment in the work lives of nursing assistants in a long-term care setting is captured by a participant observer. The analysis produces two lines of argument. One is methodological; it is argued that nursing assistants' experiences are an entry into the social relations of the setting that, when mapped and disclosed, make those experiences understandable in terms of the ruling arrangements permeating both the organization and their own experiences. The other argument is substantive; the inquiry uncovers how a quality improvement' strategy in a long term care hospital in Canada is reorganizing caregivers' values and practices toward a market orientation in which care appears to be compromised. Use of experience as data in this approach holds the analysis accountable to everyday/everynight actualities in a lived world. 相似文献