Selecting a Good Stochastic System for the Large Number of Alternatives

In this article, we present the problem of selecting a good stochastic system with high probability and minimum total simulation cost when the number of alternatives is very large. We propose a sequential approach that starts with the Ordinal Optimization procedure to select a subset that overlaps with the set of the actual best m% systems with high probability. Then we use Optimal Computing Budget Allocation to allocate the available computing budget in a way that maximizes the Probability of Correct Selection. This is followed by a Subset Selection procedure to get a smaller subset that contains the best system among the subset that is selected before. Finally, the Indifference-Zone procedure is used to select the best system among the survivors in the previous stage. The numerical test involved with all these procedures shows the results for selecting a good stochastic system with high probability and a minimum number of simulation samples, when the number of alternatives is large. The results also show that the proposed approach is able to identify a good system in a very short simulation time.     

Asymptotic Behavior of the Hazard Rate Kernel Estimator Under Truncated and Censored Data

In this article, we give the asymptotic mean integrated squared error and the mean squared error for the kernel estimator of the hazard rate from truncated and censored data. Martingale techniques and combinatory calculus are used to obtain these results. A probability bound and the optimal bandwidth choice are also given.     

Application and Reliability of Change-Point Analyses for Detecting a Defective Stage in Integrated Circuit Manufacturing

ABSTRACT

This article presents a reliable method for highlighting a defective stage within a manufacturing process when the existence of a failure is only known at the end of the process. It was developed in the context of integrated circuit manufacturing, where low costs and high yields are indispensable if the manufacturer is to be competitive. Change detection methods were used to point out the defective stage. Two methods were compared and the best chosen. Thanks to this approach, it was possible to solve some yield problems for which the engineers' investigations were far from the real cause of failure. However, there is a strong requirement to assess the reliability of the suspicions cast on the incriminated stage, otherwise engineers could be made to do useless work and time could be wasted looking into events that are not the true cause of failure. Two complementary tools were implemented for this reliability assessment and their efficiency is illustrated by several examples.     

Double Sampling Designs in Multivariate Linear Models with Missing Variables

We provide a method for finding the optimal double sampling plan for estimating the mean value of a continuous outcome. It is assumed that the fallible and true outcome data are related by a multivariate linear regression model where only some of the explanatory variables are sampled. Conditions under which double sampling is preferred over standard sampling plans are determined. An application of the method to a well-known data set on air pollution is presented.     

Confidence Intervals for the Youden Index and Corresponding Optimal Cut-Point

A global measure of biomarker effectiveness is the Youden index, the maximum difference between sensitivity, the probability of correctly classifying diseased individuals, and 1-specificity, the probability of incorrectly classifying healthy individuals. The cut-point leading to the index is the optimal cut-point when equal weight is given to sensitivity and specificity. Using the delta method, we present approaches for estimating confidence intervals for the Youden index and corresponding optimal cut-point for normally distributed biomarkers and also those following gamma distributions. We also provide confidence intervals using various bootstrapping methods. A comparison of interval width and coverage probability is conducted through simulation over a variety of parametric situations. Confidence intervals via delta method are shown to have both closer to nominal coverage and shorter interval widths than confidence intervals from the bootstrapping methods.     

Revisiting Nested Group Testing Procedures: New Results,Comparisons, and Robustness

Group testing has its origin in the identification of syphilis in the U.S. army during World War II. Much of the theoretical framework of group testing was developed starting in the late 1950s, with continued work into the 1990s. Recently, with the advent of new laboratory and genetic technologies, there has been an increasing interest in group testing designs for cost saving purposes. In this article, we compare different nested designs, including Dorfman, Sterrett and an optimal nested procedure obtained through dynamic programming. To elucidate these comparisons, we develop closed-form expressions for the optimal Sterrett procedure and provide a concise review of the prior literature for other commonly used procedures. We consider designs where the prevalence of disease is known as well as investigate the robustness of these procedures, when it is incorrectly assumed. This article provides a technical presentation that will be of interest to researchers as well as from a pedagogical perspective. Supplementary material for this article is available online.     

交通模型网络分配技术

拥挤的城市道路网络的建模工作一直是世界各国研究的课题．各种方法的准确程度也不相同,一个基本的方面就是在追求战略规划目的的同时取得成效,和在准确地表示地域范围内交通运转情况需要之间寻求一种平衡．在许多城市中,需要能够同时评价这两者的灵活的模型．OveArup＆Partners最近已经开发并成功地运用了一个EMME／2模型对奥克兰市、新西兰市做了交通项目估计,同时具体表达了交汇处的延误．这部分的前期工作是由ROHill所承担的,此模型的研究和开发强调了模型中出现的许多重要问题．本文讨论了与拥挤分配模型开发有关的问题,阐述了建立城市范围内的模型的方法．内容包括：a．分配方法;b．稳定性和收敛性;c．城市范围模型的具体水平;d．联系和转弯惩罚函数;e．在没有信号灯的交叉口的延误函数．     

渊源与价值:我国传统残疾人社会保障的历史反思

传统残疾人社会保障有着丰富的思想渊源,而各家学说于此亦存在共通之处.历朝历代也基于这些思想颁行了一系列涉残的政策和措施,包括国家收养、减免赋役、实物救助和量能授事.这些思想和做法既有其契合时代价值的一面,具有先进性、国家主导性和基础性,但受制于时代和阶级的局限,亦有其缺失权利本位性、人格独立性和法制性的不足.而构建现代残疾人社会保障制度,必须秉据史务实之态度,科学甄别和评估其价值,在延续制度的历史惯性之基础上实现制度的革故鼎新.     

Dyadic regression in the presence of heteroscedasticity—An assessment of alternative approaches

Although the problem of heteroscedasticity has been the subject of much discussion in other areas of applied statistics the problem has received scant attention in the social network literature. This study attempts to remedy this situation by considering how traditional methods for significance testing in dyadic regression models, such as standard QAP tests, perform under conditions of heteroscedasticity. Moreover, the article presents two alternative methods to deal with heteroscedasticity that are both shown to perform rather well with typical social network data under conditions of both heteroscedasticity and homoscedasticity. Overall, the results of the study suggest that applied researchers using regression techniques to study dyadic data are well advised to correct for heteroscedasticity, by either of the two methods discussed here, whenever there is a reason to suspect heteroscedasticity.     

Optimal designs for response functions with a downturn

In many toxicological assays, interactions between primary and secondary effects may cause a downturn in mean responses at high doses. In this situation, the typical monotonicity assumption is invalid and may be quite misleading. Prior literature addresses the analysis of response functions with a downturn, but so far as we know, this paper initiates the study of experimental design for this situation. A growth model is combined with a death model to allow for the downturn in mean doses. Several different objective functions are studied. When the number of treatments equals the number of parameters, Fisher information is found to be independent of the model of the treatment means and on the magnitudes of the treatments. In general, A- and D_A-optimal weights for estimating adjacent mean differences are found analytically for a simple model and numerically for a biologically motivated model. Results on c-optimality are also obtained for estimating the peak dose and the EC₅₀ (the treatment with response half way between the control and the peak response on the increasing portion of the response function). Finally, when interest lies only in the increasing portion of the response function, we propose composite D-optimal designs.