Statistics for weighing benefits and harms in a proposed genetic substudy of a randomized cancer prevention trial

Summary.  When evaluating potential interventions for cancer prevention, it is necessary to compare benefits and harms. With new study designs, new statistical approaches may be needed to facilitate this comparison. A case in point arose in a proposed genetic substudy of a randomized trial of tamoxifen versus placebo in asymptomatic women who were at high risk for breast cancer. Although the randomized trial showed that tamoxifen substantially reduced the risk of breast cancer, the harms from tamoxifen were serious and some were life threaten-ing. In hopes of finding a subset of women with inherited risk genes who derive greater bene-fits from tamoxifen, we proposed a nested case–control study to test some trial subjects for various genes and new statistical methods to extrapolate benefits and harms to the general population. An important design question is whether or not the study should target common low penetrance genes. Our calculations show that useful results are only likely with rare high penetrance genes.     

女性"隐形"地位的多元认知透视

在男性占主导地位的语言,诚如英汉语中"乞丐""医生"等职业术语和"chairman""hero"等官衔荣誉称呼之类的名词,一般性的人类泛指"a man","mankind"以及代词的非指示用法中,女性往往被置于"隐形"的地位。性别差异和性别歧视的现象已引起社会上各学科的普遍关注,然而,从认知角度对这一现象作出注解的文章寥寥。运用认知语言学中的原型和范畴理论、框架理论、心理空间和概念合成理论对此予以阐释,可为英汉语中这一现象的理论阐释提供全新的多元认知视角。     

基于层次分析法的职务绩效定量分析

针对企业绩效评价中存在的问题,引用管理决策的层次分析法,从系统论的角度,对企业职务绩效指标进行整体分析和比较,更为科学地确定了绩效体系中各指标的权重。     

The econometrics of female labor supply and children

This is a survey of applied econometric research on the effects of children on female labor supply. Reasons for interest in the topic, and a basic model and terminology, are reviewed. Concerns are raised about the possible endogeneity of child status variables, and about the instrumental variables approach for dealing with this problem. Alternative ways of conceptualizing and estimating child status effects are considered, together with selected empirical evidence. Relevant developments from the household demand literature are summarized. Basic issues of model choice are also discussed.     

Perception and control of occupational injury risks in fishery--a pilot study

The frequency of occupational accidents in fishery is high in most fishery nations. Implementation of safety measures has, however, been limited. The purpose of the present cross-sectional study was to explore Swedish fishermen's attitudes towards occupational risks and accident control. Information was acquired through a questionnaire distributed to a convenience sample of 92 fishermen. Indices were built, containing variables relevant to perceived risk levels in connection with work, perceived manageability of risks, activity in safety work, technical knowledge and individual attitudes towards risks. The results did not support earlier findings of low risk awareness and risk acceptance among fishermen. Perceived manageability of risks but not perceived risk level, accident experience or risk acceptance, were significantly associated with activity in safety work. The results suggest that safety work might benefit from efforts to develop fishermen's understanding of how the development of hazardous situations can be prevented or managed. The results do not support strategies for accident control in fishery based solely on increasing risk awareness.     

经济发展、资源功能与中国的配置绩效

经济发展理论高度重视各种资源等劳动对象的开发利用。西方经济学的信仰者由于自身存在的认识论缺陷，难以科学认识劳动对象与经济发展的内在关系，进而也难以科学论述资源在发展理论及其模型中的作用和地位。因此，必须遵循马克思的方法论，从理论为实际的反映入手，建立科学的分析模型，以此指导中国经济发展方式的转变，建立生态与经济相协调的可持续发展的资源及能源支撑体系，调整、优化资源及能源的供给与需求结构。     

指数分析中多种方法的结合运用

指数分析法在经济分析的各个领域里已得到广泛的应用。但只用单一方法分析问题往往不够全面、深入。本文以工业劳动生产率的分析为例,从三个方面,多角度、多层次、比较系统地阐述了指数分析中独具特色的分析手法。     

Human immunodeficiency virus risk: is it possible to dissuade people from having unsafe sex?

Summary. The cumulative number of human immunodeficiency virus (HIV) infections worldwide has reached 60 million in little over 30 years. HIV continues to spread despite a detailed understanding of the manner in which it spreads and measures which can prevent spread. Some governments have been highly successful in containing the spread of HIV through blood products and from mother to child and among injecting drug users. Lack of political will, lack of resources or challenges to widely accepted scientific evidence have held back similar interventions in other countries. It has proved much more difficult to reduce the sexual transmission of HIV in both high and low income countries. A wide range of strategies has been identified but it remains unclear which strategies deserve priority and what methods of promoting them have the greatest effect. There is ample evidence that awareness of HIV and changes in sexual behaviour have occurred widely but the penetration of information remains poor in some vulnerable groups especially adolescents and women in poorer countries. Further obstacles face those who have information about the risk. The subordinate position of women and a desire for large families are important obstacles to condom negotiation and use. Urbanization, poverty, conflict and declining public services all exacerbate unsafe sexual behaviour. We argue that so-called 'structural' interventions directed at these wider contexts of unsafe behaviour merit greater attention. Such approaches have the added benefit of being less susceptible to 'risk compensation' which has the potential to undermine strategies directed at reducing the transmission efficiency of HIV.     

对社会工作的现状调查与分析——以绍兴市为例

对绍兴139名社会工作的管理和从业人员进行了调查,发现绍兴市社会工作存在人才数量不够、素质不高、结构不合理,社会管理中介组织发展缓慢以及管理政策不配套等三个方面的主要问题。为加强社会工作,应从加强组织领导、健全各项机制、培育民间组织、加强宣传引导等四个方面入手。     

在应对入世后我国农业面临的挑战中分析测试技术和科学仪器担负的重任

本文概叙了入世后中国农业面临的农产品品质 安全性及价格的三重冲击和应采取的应对措施 着重分析了农产品安全问题和食品安全保障体系的构建 论述了分析测试技术和科学仪器的七项重任