Inference in Targeted Group‐Sequential Covariate‐Adjusted Randomized Clinical Trials

This article is devoted to the construction and asymptotic study of adaptive, group‐sequential, covariate‐adjusted randomized clinical trials analysed through the prism of the semiparametric methodology of targeted maximum likelihood estimation. We show how to build, as the data accrue group‐sequentially, a sampling design that targets a user‐supplied optimal covariate‐adjusted design. We also show how to carry out sound statistical inference based on such an adaptive sampling scheme (therefore extending some results known in the independent and identically distributed setting only so far), and how group‐sequential testing applies on top of it. The procedure is robust (i.e. consistent even if the working model is mis‐specified). A simulation study confirms the theoretical results and validates the conjecture that the procedure may also be efficient.     

HAZARD RATE ESTIMATION FOR CENSORED DATA BY WAVELET METHODS

ABSTRACT

We study the estimation of a hazard rate function based on censored data by non-linear wavelet method. We provide an asymptotic formula for the mean integrated squared error (MISE) of nonlinear wavelet-based hazard rate estimators under randomly censored data. We show this MISE formula, when the underlying hazard rate function and censoring distribution function are only piecewise smooth, has the same expansion as analogous kernel estimators, a feature not available for the kernel estimators. In addition, we establish an asymptotic normality of the nonlinear wavelet estimator.     

Nonparametric tests for scale shift at an unknown time point

A class of linear rank tests is suggested for testing a shift in scale at an unknown time point in a sequence of independent observations. The tests,based on inverse normal scores and on ordered exponential scores,are shown to be asymptotically as efficient as their distribution-oriented competitors. Critical values and powers for these two rank tests are also discussed.     

On the asymptotic distribution of cramer-von mises one-sample test statistics under an alternative

The asymptotic normality of the Cramer-von Mises one-sample test statistic and one of its variants under an alternative cdf is demonstrated. The derivation herein is unique in that it does not require knowledge of the theory of weak convergence of probability measures defined on metrized function spaces, and thus is accessible to a broader class of students and practitioners.     

Optimal designs for exponential regression

This paper is concerned with the optimal design problem for the particular case of non-linear parametrisation:the parameters to be estimated are included in exponents.Some properties of locally optimal designs as functions of estimated parameters are investigated and a table of such designs in given.We consider also designs to be optimal in the sense of minimax approach.     

An Orthogonality‐Based Estimation of Moments for Linear Mixed Models

Abstract. Estimating higher‐order moments, particularly fourth‐order moments in linear mixed models is an important, but difficult issue. In this article, an orthogonality‐based estimation of moments is proposed. Under only moment conditions, this method can easily be used to estimate the model parameters and moments, particularly those of higher order than the second order, and in the estimators the random effects and errors do not affect each other. The asymptotic normality of all the estimators is provided. Moreover, the method is readily extended to handle non‐linear, semiparametric and non‐linear models. A simulation study is carried out to examine the performance of the new method.     

Aalen's Linear Model for Sampled Risk Set Data: A Large Sample Study

Borgan and Langholz (1997) describe a method for estimating the parameter functions in Aalen's linear hazard regression model from sampled risk set data. Using a counting process formulation and the martingale central limit theorem, we provide a study of the asymptotic distributional properties of the estimator. The results are applied to study the efficiencies of the nested case-control and counter-matched designs relative to a full cohort analysis.     

二阶非线性时滞微分方程解的渐近性

本文建立了二阶非线性时滞微分方程解的渐近性结果及全局吸引定理,改进和推广了二阶线性方程和一阶非线性方程的已知定理。     

Asymptotic properties of a generalized regression-type predictor of a finite population variance in probability sampling

A system of predictors for estimating a finite population variance is defined and shown to be asymptotically design-unbiased (ADU) and asymptotically design-consistent (ADC) under probability sampling. An asymptotic mean squared error (MSE) of a generalized regression-type predictor, generated from the system, is obtained. The suggested predictor attains the minimum expected variance of any design-unbiased estimator when the superpopulation model is correct. The generalized regression-type predictor and the predictor suggested by Mukhopadhyay (1990) are compared.     

Estimating the fundamental frequency of a periodic function

In this paper we consider the problem of estimation of the fundamental frequency of a periodic function, which has several applications in Speech Signal Processing. The problem was originally proposed by Hannan (1974) and later on Quinn and Thomson (1991) provided an estimation procedure of the unknown parameters. It is observed that the estimation procedure of Quinn and Thomson (1991) is quite involved numerically. In this paper we propose to use two simple estimators and it is observed that their performance are quite satisfactory. Asymptotic properties of the proposed estimators are obtained. The large sample properties of the estimators are compared theoretically. We present some simulation results to compare their small sample performance. One speech data is analyzed using this particular model.