Benchmark Dose Analysis via Nonparametric Regression Modeling

Estimation of benchmark doses (BMDs) in quantitative risk assessment traditionally is based upon parametric dose‐response modeling. It is a well‐known concern, however, that if the chosen parametric model is uncertain and/or misspecified, inaccurate and possibly unsafe low‐dose inferences can result. We describe a nonparametric approach for estimating BMDs with quantal‐response data based on an isotonic regression method, and also study use of corresponding, nonparametric, bootstrap‐based confidence limits for the BMD. We explore the confidence limits’ small‐sample properties via a simulation study, and illustrate the calculations with an example from cancer risk assessment. It is seen that this nonparametric approach can provide a useful alternative for BMD estimation when faced with the problem of parametric model uncertainty.     

Keeping Surveys Valid,Reliable, and Useful: A Tutorial

This tutorial focuses on how to produce reliable and generalizable data from random‐digit‐dialing (RDD) landline and cell phone surveys. The article notes that RDD response rates have declined and explores the impact of this pronounced decline. The tutorial addresses order, response mode, and many other biases, sample size, cooperation and response rates, weighting, and hybrid designs‐all using examples from risk analysis to illustrate the key points. The article ends with a brief review of the advantages and disadvantages of major Internet and paper surveys tools, and how these can be molded and sometimes combined in repeated, longitudinal, and other designs to answer questions about risk preferences and perceptions.     

Protection of privacy in efficient application of randomized response techniques

In estimating the proportion of people bearing a sensitive attribute A, say, in a given community, following Warner’s (J Am Stat Assoc 60:63–69, 1965) pioneering work, certain randomized response (RR) techniques are available for application. These are intended to ensure efficient and unbiased estimation protecting a respondent’s privacy when it touches a person’s socially stigmatizing feature like rash driving, tax evasion, induced abortion, testing HIV positive, etc. Lanke (Int Stat Rev 44:197–203, 1976), Leysieffer and Warner (J Am Stat Assoc 71:649–656, 1976), Anderson (Int Stat Rev 44:213–217, 1976, Scand J Stat 4:11–19, 1977) and Nayak (Commun Stat Theor Method 23:3303–3321, 1994) among others have discussed how maintenance of efficiency is in conflict with protection of privacy. In their RR-related activities the sample selection is traditionally by simple random sampling (SRS) with replacement (WR). In this paper, an extension of an essential similarity in case of general unequal probability sample selection even without replacement is reported. Large scale surveys overwhelmingly employ complex designs other than SRSWR. So extension of RR techniques to complex designs is essential and hence this paper principally refers to them. New jeopardy measures to protect revelation of secrecy presented here are needed as modifications of those in the literature covering SRSWR alone. Observing that multiple responses are feasible in addressing such a dichotomous situation especially with Kuk’s (Biometrika 77:436–438, 1990) and Christofides’ (Metrika 57:195–200, 2003) RR devices, an average of the response-specific jeopardizing measures is proposed. This measure which is device dependent, could be regarded as a technical characteristic of the device and it should be made known to the participants before they agree to use the randomization device. The views expressed are the authors’, not of the organizations they work for. Prof Chaudhuri’s research is partially supported by CSIR Grant No. 21(0539)/02/EMR-II.     

Do “Clicker” Educational Sessions Enhance the Effectiveness of a Social Norms Marketing Campaign?

Abstract

Objective: Social norms campaigns are a cost-effective way to reduce high-risk drinking on college campuses. This study compares effectiveness of a “standard” social norms media (SNM) campaign for those with and without exposure to additional educational sessions using audience response technology (“clickers”). Methods: American College Health Association's National College Health Assessment questions are used to evaluate actual and perceived use. Additional survey questions assess individual exposure to the interventions. Results: The authors find “clicker” technology to be more effective than social norms poster media alone in reducing misperceptions of normative alcohol use for those students who attended clicker sessions. Conclusion: Poster SNM campaigns may be most effective when supported by group “clicker” heath-related sessions.     

On a characterization of the dispersion matrix based on the properties of regression

This paper provides a partial solution to a problem posed by J. Neyman (1965) regarding the characterization of multivariate negative binomial distribution based on the properties of regression. It is shown that some of the properties of regression characterize the form of the nonsingular dispersion matrix of the parent distribution, which, interestingly enough, corresponds to only two types viz. those of positive and negative multivariate binomial distributions.     

Employee Assistance Program Staffing

No abstract available for this article.     

On Second-Order A-, D- and E-Minimax Designs for Estimating Slopes in Extrapolation and Restricted Interpolation Regions

Summary

The concepts of D-, A- and E-minimax optimality criteria of designs for estimating the slopes of a response surface are considered for situations where the region of interest may not be identical to the experimental region. Optimal second-order designs are derived for the situation where the experimental region and the region of interest are both hyperspherical with a common centre. The dependence of the optimal design on the relative sizes of the regions is investigated. Further, the perfomance of designs optimal for one region in estimating slopes in other regions is also examined.     

Sensitivity studies of air scattered neutron dose from particle accelerators

Sensitivity analysis of air scattered neutron dose at several distances from a particle accelerator with respect to shield thickness and neutron yield distributions has been carried out. We illustrate the successful use of Response Surface Methodology in studying the behaviour of the sensitivity coefficients for main effects and interaction terms. A comparison of the full six factor design and the orthogonal Central Composite Design has been made. The overhead shield is found to be the most sensitive parameter followed by the high energy part of the neutron energy distribution.     

Response-Response Relationships in Organizational Behavior Management

Abstract

The issue of behavioral covariation has been a topic of interest to behavior analysts for many years. Many writers have used the term response generalization interchangeably with behavioral covariation. In this paper, we argue from the extant literature that the term “response generalization” should be used to describe only very specific occasions of behavioral covariation. In fact, we argue, response generalization is merely one of at least six types of behavioral covariation observed in organizational behavior management studies. After describing response generalization, the remaining five types of response-response relations we describe are: (1) physiological relations, (2) when target behaviors occasion related behaviors, (3) when target behaviors reinforce related behaviors, (4) when target and related behaviors are maintained by the same reinforcing stimulus, and (5) covariation through participation in verbal relations. We conclude by discussing the potential for additional research on this topic in the area of verbal relations.