Adaptive Crossover Design for Normal Responses

In a response-adaptive design, we review and update the trial on the basis of outcomes in order to achive a specific goal. In clinical trials our goal is to allocate a larger number of patients to the better treatment. In the present paper, we use a response adaptive design in a two-treatment two-period crossover trial where the treatment responses are continuous. We provide probability measures to choose between the possible treatment combinations AA, AB, BA, or BB. The goal is to use the better treatment combination a larger number of times. We calculate the allocation proportions to the possible treatment combinations and their standard errors. We also derive some asymptotic results and provide solutions on related inferential problems. The proposed procedure is compared with a possible competitor. Finally, we use a data set to illustrate the applicability of our proposed design.     

On Upshifted Reversed Mean Residual Life Order

Recently, the concept of reversed mean residual life order based on the mean of the random variable X _t  = (t ? X | X ≤ t), t > 0, called the reversed residual life, defined for the nonnegative random variable X, has been introduced in the literature. In this paper, a stochastic order based on the shifted version of the reversed mean residual life is proposed, based on the reversed mean residual life function for a random variable X with support (l _X , ∞), where l _X may be negative infinity, and its properties are studied. Closure under the Poisson shock model and properties for spare allocation are also discussed.     

Combining Univariate Tests for Multivariate Location Problem

In this article, three methods of combining dependent univariate tests are studied. The Bahadur approximate efficiencies are derived under the asymptotic normal assumption. These procedures are applied to the multivariate location problem and compared with two Hotelling-type tests. A Monte Carlo study indicates that in certain cases the powers of the combination methods are much better than Hotelling's T ² and other multivariate nonparametric tests.     

Smooth goodness of fit tests for the weibull distribution with singly censored data

The smooth goodness of fit tests are generalized to singly censored data and applied to the problem of testing Weibull (or extreme value) fit. Smooth tests, Pearson-type tests, and the spacings tests proposed by Mann, Schemer, and Fertig (1973) are compared on the basis of local asymptotic relative efficiency with respect to the asymptotic best test against generalized gamma alternatives, The smooth test of order one Is found to be most efficient for the generalized gamma alternatives.     

Tests for symmetry about an unknown value based on the empirical distribution function

A class of Kolmogorov-Smirnov and Cramér-von Mises type statistics for testing symmetry about an unknown value is described. These statistics are not distribution-free, however, and, indeed, are not readily amenable to calculation. A linear rank statistic analog of the first component of the Cramér-von Mises type statistic is investigated. Asymptotic non-null properties of these procedures in the normal case are studied, and an efficiency comparison of the Cramér-vonMises statistic, the linear rank statistic analog, the modified Wil-coxon statistic, and the likelihood ratio test is reported.     

Nonparametric tests for scale shift at an unknown time point

A class of linear rank tests is suggested for testing a shift in scale at an unknown time point in a sequence of independent observations. The tests,based on inverse normal scores and on ordered exponential scores,are shown to be asymptotically as efficient as their distribution-oriented competitors. Critical values and powers for these two rank tests are also discussed.     

On the asymptotic efficiency of moment and maximum likelihood estimators in the three-parameter inverse gaussian distribution

The asymptotic distribution of estimators generated by the methods of moments and maximum likelihood are considered. Simple formulae are provided which enable comparisons of asymptotic relative efficiency to be effected.     

On tail-ordering and comparison of failure rates

In this paper, we have studied some implications between tail-ordering (also known as dispersive ordering) and failure rate ordering (also called TP₂ ordering) of two probability distribution functions. Based on independent random samples from these distributions, a class of distribution-free tests has been proposed for testing the null hypothesis that the two life distributions are identical against the alternative that one failure rate is uniformly smaller than the other. The tests have good efficiencies as compared to their competitors.     

An asymptotic distribution-free selection procedure for a two-way layout problem

This paper deals with an asymptotic distribution-free subset selection procedure for a two-way layout problem. The treatment effect with the largest unknown value is of interest to us. The block effect is a nuisance parameter in this problem. The proposed procedure is based on the Hodges-Lehmann estimators of location parameters. The asymptotic relative efficiency of the proposed procedure with the normal means procedure is evaluated. It is shown that the proposed procedure has a high efficiency.     

Anderson's classification statistic based on a post-stratified training sample

The performance of Anderson's classification statistic based on a post-stratified random sample is examined. It is assumed that the training sample is a random sample from a stratified population consisting of two strata with unknown stratum weights. The sample is first segregated into the two strata by post-stratification. The unknown parameters for each of the two populations are then estimated and used in the construction of the plug-in discriminant. Under this procedure, it is shown that additional estimation of the stratum weight will not seriously affect the performance of Anderson's classification statistic. Furthermore, our discriminant enjoys a much higher efficiency than the procedure based on an unclassified sample from a mixture of normals investigated by Ganesalingam and McLachlan (1978).