The exoskeleton generation – disability redux

From both ethical and scientific standpoints, disability is increasingly seen as a state within which a person is both entitled to be and capable of being remediated. Legal and ethical acceptance of disability has taken place at the same time as rapid scientific developments which present major tensions in how we understand disability and social inclusion. This article explores some of the implications of these developments.     

A Faith‐Based Advantage?

This study explored whether religiously affiliated nonprofit schools participating in Milwaukee's long‐standing school voucher program engage in more fundraising and perform better on academic indicators than nonsectarian nonprofit schools. The analysis of three years of organizational‐level voucher school data reveals that a higher percentage of religious affiliated schools engage in fundraising, and that religious schools affiliated with umbrella organizations have higher test score indicators than nonsectarian schools. The author concludes that the religious advantage is likely in part a result of the broader access to networks and resources available to religious schools associated with umbrella organizations like a Catholic archdiocese or Lutheran synod. The results are relevant to policymakers who are considering implementing a reinvented government approach to the provision of public goods, as well as leaders of nonprofit corporations who seek to maximize performance.     

The Attributes of Effective NGOs and the Leadership Values Associated with a Reputation for Organizational Effectiveness

Building on prior research characterizing organizational effectiveness as a social construction, this article identifies the perceived attributes of effective transnational nongovernmental organizations (NGOs) and the leadership values associated with higher reputations for organizational effectiveness. Results are based on an in‐depth, mixed‐method interview study of 152 NGO leaders located in the United States and representing all major sectors of organizational activity. Among the twenty‐nine attributes that leaders identified in peer organizations that they regarded as particularly effective, leaders stressed instantiation of sound principles or strategy, a grassroots approach, large organizational size and resources, being collaborative, singleness of focus, campaigning abilities, funding and fundraising prowess, global scope, and quality people. Furthermore, statistical analysis reveals that NGOs with leaders who value similarities with peer organizations, grassroots approaches, diversity of strategies, dedication, professionalism, and distributed organizational structures have significantly higher reputations for effectiveness.     

Social Relations Model Analyses of Perceived Self‐Control and Trust in Families

How do people know which family member is trustworthy? In this study, the authors tested the hypothesis that people use their perception of a family member's self‐control as an indicator of his or her trustworthiness. Eighty‐four Dutch families consisting of 2 parents and 2 children completed questionnaires assessing each family member's trust in and perceived self‐control of the other 3 family members. This full‐family design enabled the authors to examine their hypothesis in horizontal relationships, between family members of equal status (i.e., parent–parent and sibling–sibling relationships), and vertical relationships, in which partners have unequal status (i.e., parent–child and child–parent relationships). Consistent with the hypothesis, Social Relations Model analyses showed that being perceived as having higher self‐control is related to greater trustworthiness among adults and children in the large majority of horizontal and vertical relationships (10 out of 12). These findings highlight that perceived self‐control is an important factor by which to gauge trustworthiness in families.     

Intergenerational Exchanges of Middle‐Aged Adults With Their Parents and Parents‐In‐Law in Korea

The authors investigated patterns of support exchanges between Korean adult children and their parents and parents‐in‐law, gender differences in these patterns, and implications of children's marital quality for exchange patterns. Data were from a nationally representative sample of married adults (N = 920, age 30–59 years) with at least 1 living parent and 1 living parent‐in‐law. Latent class analysis was applied to 12 indicators of exchanges (financial, instrumental, emotional support given to and received from parents and parents‐in‐law). Five classes of exchanges were identified, 3 showing balanced patterns of exchanges with parents and parents‐in‐law across three types of support and 2 classes with unbalanced patterns (e.g., giving instrumental and financial but not emotional support). The findings revealed variability in intergenerational exchange patterns, with a mix of patrilineal traditional and balanced patterns. Significant associations of exchange patterns with adult children's marital quality suggest the importance of balanced exchanges with parents for marriage.     

Respectability,morality and disgust in the night‐time economy: exploring reactions to ‘lap dance’ clubs in England and Wales

The night‐time economy is often described as repelling consumers fearful of the ‘undesirable Others’ imagined dominant within such time‐spaces. In this paper we explore this by describing attitudes towards, and reactions to, one particularly contentious site: the ‘lap dance’ club. Often targeted by campaigners in England and Wales as a source of criminality and anti‐sociality, in this paper we shift the focus from fear to disgust, and argue that Sexual Entertainment Venues (SEVs) are opposed on the basis of moral judgments that reflect distinctions of both class and gender. Drawing on documentary analysis, survey results and interview data collected during guided walks, we detail the concerns voiced by those anxious about the presence of lap dance or striptease clubs in their town or city, particularly the notion that they ‘lower the tone’ of particular streets or neighbourhoods. Our conclusion is that the opposition expressed to lap dance clubs is part of an attempt to police the boundaries of respectable masculinities and femininities, marginalizing the producers and consumers of sexual entertainment through ‘speech acts’ which identify such entertainment as unruly, vulgar and uncivilized. These findings are considered in the light of ongoing debates concerning the relations of morality, respectability and disgust.     

Likelihood analysis for a class of beta mixed models

Beta regression is a suitable choice for modelling continuous response variables taking values on the unit interval. Data structures such as hierarchical, repeated measures and longitudinal typically induce extra variability and/or dependence and can be accounted for by the inclusion of random effects. In this sense, Statistical inference typically requires numerical methods, possibly combined with sampling algorithms. A class of Beta mixed models is adopted for the analysis of two real problems with grouped data structures. We focus on likelihood inference and describe the implemented algorithms. The first is a study on the life quality index of industry workers with data collected according to an hierarchical sampling scheme. The second is a study assessing the impact of hydroelectric power plants upon measures of water quality indexes up, downstream and at the reservoirs of the dammed rivers, with a nested and longitudinal data structure. Results from different algorithms are reported for comparison including from data-cloning, an alternative to numerical approximations which also allows assessing identifiability. Confidence intervals based on profiled likelihoods are compared with those obtained by asymptotic quadratic approximations, showing relevant differences for parameters related to the random effects. In both cases, the scientific hypothesis of interest was investigated by comparing alternative models, leading to relevant interpretations of the results within each context.     

Methods for exploring treatment effect heterogeneity in subgroup analysis: an application to global clinical trials

Multi‐country randomised clinical trials (MRCTs) are common in the medical literature, and their interpretation has been the subject of extensive recent discussion. In many MRCTs, an evaluation of treatment effect homogeneity across countries or regions is conducted. Subgroup analysis principles require a significant test of interaction in order to claim heterogeneity of treatment effect across subgroups, such as countries in an MRCT. As clinical trials are typically underpowered for tests of interaction, overly optimistic expectations of treatment effect homogeneity can lead researchers, regulators and other stakeholders to over‐interpret apparent differences between subgroups even when heterogeneity tests are insignificant. In this paper, we consider some exploratory analysis tools to address this issue. We present three measures derived using the theory of order statistics, which can be used to understand the magnitude and the nature of the variation in treatment effects that can arise merely as an artefact of chance. These measures are not intended to replace a formal test of interaction but instead provide non‐inferential visual aids, which allow comparison of the observed and expected differences between regions or other subgroups and are a useful supplement to a formal test of interaction. We discuss how our methodology differs from recently published methods addressing the same issue. A case study of our approach is presented using data from the Study of Platelet Inhibition and Patient Outcomes (PLATO), which was a large cardiovascular MRCT that has been the subject of controversy in the literature. An R package is available that implements the proposed methods. Copyright © 2014 John Wiley & Sons, Ltd.     

Threshold‐free estimation of functional antibody titers of a group B streptococcus opsonophagocytic killing assay

Opsonophagocytic killing assays (OPKA) are routinely used for the quantification of bactericidal antibodies in blood serum samples. Quantification of the OPKA readout, the titer, provides the basis for the statistical analysis of vaccine clinical trials having functional immune response endpoints. Traditional OPKA titers are defined as the maximum serum dilution yielding a predefined bacterial killing threshold value, and they are estimated by fitting a dose‐response model to the dilution‐killing curve. This paper illustrates a novel definition of titer, the threshold‐free titer, which preserves biological interpretability while not depending on any killing threshold or on a postulated shape of the dose‐response curve. These titers are shown to be more precise than the traditional threshold‐based titers when using simulated and experimental group B streptococcus OPKA experimental data. Also, titer linearity is shown to be not measurable when using threshold‐based titers, whereas it becomes measurable using threshold‐free titers. The biological interpretability and operational characteristics demonstrated here indicate that threshold‐free titers are an appropriate tool for the routine analysis of OPKA data. Copyright © 2015 John Wiley & Sons, Ltd.     

Flexible modelling of simultaneously interval censored and truncated time‐to‐event data

This paper deals with the analysis of data from a HET‐CAM^VT experiment. From a statistical perspective, such data yield many challenges. First of all, the data are typically time‐to‐event like data, which are at the same time interval censored and right truncated. In addition, one has to cope with overdispersion as well as clustering. Traditional analysis approaches ignore overdispersion and clustering and summarize the data into a continuous score that can be analysed using simple linear models. In this paper, a novel combined frailty model is developed that simultaneously captures all of the aforementioned statistical challenges posed by the data. Copyright © 2015 John Wiley & Sons, Ltd.