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111.
王国维在小说批评方面的代表作是《〈红楼梦〉评论》。其中运用的进化的文学史、严格的逻辑推理、艺术的审美理论为近代小说批评方法提供了借鉴  相似文献   
112.
The quantification of the relationship between the amount of microbial organisms ingested and a specific outcome such as infection, illness, or mortality is a key aspect of quantitative risk assessment. A main problem in determining such dose-response models is the availability of appropriate data. Human feeding trials have been criticized because only young healthy volunteers are selected to participate and low doses, as often occurring in real life, are typically not considered. Epidemiological outbreak data are considered to be more valuable, but are more subject to data uncertainty. In this article, we model the dose-illness relationship based on data of 20 Salmonella outbreaks, as discussed by the World Health Organization. In particular, we model the dose-illness relationship using generalized linear mixed models and fractional polynomials of dose. The fractional polynomial models are modified to satisfy the properties of different types of dose-illness models as proposed by Teunis et al . Within these models, differences in host susceptibility (susceptible versus normal population) are modeled as fixed effects whereas differences in serovar type and food matrix are modeled as random effects. In addition, two bootstrap procedures are presented. A first procedure accounts for stochastic variability whereas a second procedure accounts for both stochastic variability and data uncertainty. The analyses indicate that the susceptible population has a higher probability of illness at low dose levels when the combination pathogen-food matrix is extremely virulent and at high dose levels when the combination is less virulent. Furthermore, the analyses suggest that immunity exists in the normal population but not in the susceptible population.  相似文献   
113.
白先勇尝试运用现代派文学的表现技巧——意识流创作手法始于与台湾大学外文系同学创办《现代文学》杂志。以后,随着作家自身经历的变化和对意识流创作理论认识的深入,其笔下意识流这一创作手法呈现出鲜明的“模仿试睑一成熟定型——在扬弃中提升”的变化轨迹。  相似文献   
114.
线性科学与非线性科学哲学思想研究   总被引:1,自引:0,他引:1  
在简述线性科学的科学基础、科学方法和哲学思想的基础上,研究了非线性科学的科学基础、科学方法和哲学思想,其中较为详细地探讨了非线性科学的哲学范畴和哲学思想,认为要多角度观察事物,要从变化中认识主要矛盾,事物的发展是多元竞争与协同的统一,这一结果将对非线性科学的哲学思想的进一步研究有一定的启发和借鉴作用。  相似文献   
115.
The benchmark dose (BMD) is an exposure level that would induce a small risk increase (BMR level) above the background. The BMD approach to deriving a reference dose for risk assessment of noncancer effects is advantageous in that the estimate of BMD is not restricted to experimental doses and utilizes most available dose-response information. To quantify statistical uncertainty of a BMD estimate, we often calculate and report its lower confidence limit (i.e., BMDL), and may even consider it as a more conservative alternative to BMD itself. Computation of BMDL may involve normal confidence limits to BMD in conjunction with the delta method. Therefore, factors, such as small sample size and nonlinearity in model parameters, can affect the performance of the delta method BMDL, and alternative methods are useful. In this article, we propose a bootstrap method to estimate BMDL utilizing a scheme that consists of a resampling of residuals after model fitting and a one-step formula for parameter estimation. We illustrate the method with clustered binary data from developmental toxicity experiments. Our analysis shows that with moderately elevated dose-response data, the distribution of BMD estimator tends to be left-skewed and bootstrap BMDL s are smaller than the delta method BMDL s on average, hence quantifying risk more conservatively. Statistically, the bootstrap BMDL quantifies the uncertainty of the true BMD more honestly than the delta method BMDL as its coverage probability is closer to the nominal level than that of delta method BMDL. We find that BMD and BMDL estimates are generally insensitive to model choices provided that the models fit the data comparably well near the region of BMD. Our analysis also suggests that, in the presence of a significant and moderately strong dose-response relationship, the developmental toxicity experiments under the standard protocol support dose-response assessment at 5% BMR for BMD and 95% confidence level for BMDL.  相似文献   
116.
In the non-conjugate Gibbs sampler, the required sampling from the full conditional densities needs the adoption of black-box sampling methods. Recent suggestions include rejection sampling, adaptive rejection sampling, generalized ratio of uniforms, and the Griddy-Gibbs sampler. This paper describes a general idea based on variate transformations which can be tailored in all the above methods and increase the Gibbs sampler efficiency. Moreover, a simple technique to assess convergence is suggested and illustrative examples are presented.  相似文献   
117.
讨论了双交错Millitron慢波系统的设计方法,并采用通过式谐振法对双交错Millitron的色散特性进行了实验研究,给出了实验结果,并和作者所得到的理论结果[4]进行了比较,分析了出现误盖的原因。  相似文献   
118.
提出了一种新颖的基于双恒流源法六端比例测量原理的应变测量技术,介绍了其测量原理及误差分析和校准技术,实现了高精度应变测量。给出了利用该测量原理设计的多通道应变仪测试结果。实验室测试及在某大型离心载荷试验中运行表明,该应变仪具有较高的测量精度、稳定性、抗干扰性和可靠性,其设计原理和方法对于工程设计与应用具有一定的参考价值。  相似文献   
119.
The mean density of bacteria in a water body is commonly monitored using quantal assay. This paper describes the use of local scoring in estimating the spatial distribution of mean density from quantal assay results at a set of point locations. An application to estimating the mean density of fecal conform bacteria in a coastal pond is presented. Model diagnostics based on a parametric bootstrap are also presented.  相似文献   
120.
本文用最优化理论中的Powell直接法求激光粒度仪中的颗粒尺寸分布。数值模拟及对标准颗粒的实测表明,该算法的计算精度高,能较好地解决粒度仪通常存在的计算结果随初始设定值变化的多值性问题。  相似文献   
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