Detecting homogeneous segments in DNA sequences by using hidden Markov models

In recent years there has been a rapid growth in the amount of DNA being sequenced and in its availability through genetic databases. Statistical techniques which identify structure within these sequences can be of considerable assistance to molecular biologists particularly when they incorporate the discrete nature of changes caused by evolutionary processes. This paper focuses on the detection of homogeneous segments within heterogeneous DNA sequences. In particular, we study an intron from the chimpanzee α-fetoprotein gene; this protein plays an important role in the embryonic development of mammals. We present a Bayesian solution to this segmentation problem using a hidden Markov model implemented by Markov chain Monte Carlo methods. We consider the important practical problem of specifying informative prior knowledge about sequences of this type. Two Gibbs sampling algorithms are contrasted and the sensitivity of the analysis to the prior specification is investigated. Model selection and possible ways to overcome the label switching problem are also addressed. Our analysis of intron 7 identifies three distinct homogeneous segment types, two of which occur in more than one region, and one of which is reversible.     

印度妇女的哀歌——浅论《丧宴》的思想性

印度妇女是世界上最为悲惨的妇女,森严的封建礼法制度规定她们处于无权地位———从人格到经济上都得不到独立;而印度特有的封建产物———种姓制度又给她们牢牢地加缚了一条锁链     

国际关系理论中的主权与人权问题

主权与人权问题不仅是国际关系理论的两个主要范畴,也是给当今国际社会现实生活带来巨大影响的热点。在诸如主权原则、人权概念、二者的关系,人权的国际化趋势与国内管辖权的矛盾,以及由此对传统国际关系理论造成的冲击和对国际法、国际关系基本准则的挑战等方面,人们确有深入思考、探究和冷静应对的必要     

人机工程学的发展及人机系统的可靠性

本文介绍了人机工程学(工效学)这一新兴边缘学科的研究内容、发展及现状,讨论了人-机系统的可靠性并着重讨论了人的操作可靠性,探讨了按人为差错进行可靠性分析与可靠性估计的人为差错和可靠性分析逻辑推演法(HERALD法)及系统能力方法(SC方法)。 本文的结论可供系统管理工作者及设计工作者,特别是可靠性管理及可靠性设计工作者参考。     

Naturing the Nation: Aliens,Apocalypse, and the Postcolonial State

The purpose of this study is to understand how the British Canadian Frank Schofield transformed himself into an established missionary scholar and nobleman in Korea. The study employs its framework from the structure of cultural exchange itself in its survey of Schofield's career. It examines the relevant aspects of Korean and Western cultures, and the characteristics of Schofield who linked them. The case, including themes significant both to Korean and Western cultures, such as the importance of spirituality, an emphasis on education, and the ideals of justice and love, explains reasons for his success as a cultural mediator between Korea and the West. It reveals that the flow of information and ideas between Koreans and Schofield illustrates the ability of intercultural contact to influence the initiating as well as receiving culture. It suggests that such a distinction between sender and receiver may carry little ultimate significance. Finally, it argues that individuals of different cultures can convey information and ideas effectively only if the conveyer learns about the target individuals for the information and ideas, and communicates on the basis of that knowledge, as intercultural communications occur between the individuals of different cultures.     

Estimation of the Force of Infection from Current Status Data Using Generalized Linear Mixed Models

Based on sero-prevalence data of rubella, mumps in the UK and varicella in Belgium, we show how the force of infection, the age-specific rate at which susceptible individuals contract infection, can be estimated using generalized linear mixed models (McCulloch & Searle, 2001). Modelling the dependency of the force of infection on age by penalized splines, which involve fixed and random effects, allows us to use generalized linear mixed models techniques to estimate both the cumulative probability of being infected before a given age and the force of infection. Moreover, these models permit an automatic selection of the smoothing parameter. The smoothness of the estimated force of infection can be influenced by the number of knots and the degree of the penalized spline used. To determine these, a different number of knots and different degrees are used and the results are compared to establish this sensitivity. Simulations with a different number of knots and polynomial spline bases of different degrees suggest - for estimating the force of infection from serological data - the use of a quadratic penalized spline based on about 10 knots.     

论王安石“善恶由习”人性论的理论渊源及其内容

传统人性论是王安石人性论形成的理论来源。传统伦理思想史上的人性论主要有孟子的性善论、告子的性无善无恶论、苟子的性恶论、世硕的性有善有恶论、董仲舒的性三品论、扬雄的性善恶混论和韩愈的性情三品说。王安石批判地吸收了前人的人性论成果,形成了他的“善恶由习”的人性论。他的人性论给传统人性论注入了新的内涵,开拓了新的境界,因而在中国伦理思想史上具有重要的地位。     

中国奢侈品消费的动因分析

随着当前我国奢侈品消费人数的不断攀升及奢侈品消费金额的不断提高,中国的奢侈品消费从整体上看未富先奢的局面已经出现。其大致可分为两类：一类是传统奢侈品的消费,消费人群主要集中在超富裕阶层;另一类是新奢侈品的消费,消费人群是中产阶级和白领。从影响我国消费者奢侈品消费的主要动机来看,人际性消费是影响我国奢侈品消费的主要动机,其中符号性消费是影响我国当前奢侈品消费的首要因素。符号性消费、从众性消费与人情消费都属于非理性的消费行为,促使我国奢侈品消费呈现出一种非理性状态。因此．应大力倡导理性消费．同时也要抓住契机。加大宣传营销力度与创新．树立自己的民族奢侈品牌,更好地发施我国经济     

Quantifying the Distribution of Inhalation Exposure in Human Populations: 2. Distributions of Time Spent by Adults, Adolescents, and Children at Home, at Work, and at School

Using distributions of time spent at various ventilation levels, ranges of inhalation exposure in the population can be established. Distributions of exposure time were determined using results of a study by the California Air Resources Board (CARB) which focused on time spent by humans participating in various activities and the locations where the activities occurred. The daily at-home activities from the CARB study were assigned to one of three ventilation levels, generating aggregate time periods. Distinct age and gender populations were identified, and distributions for aggregate time were established for these populations at each of the ventilation levels. In addition to aggregate time spent at home, distributions for various ages and genders were established for aggregate time spent at school and work. By combining distributions of aggregate time with corresponding ventilation rates, the distribution of inhalation rates can be established for at home, at work, and at school exposures.     

从国际人权立法与实践视角探讨少数民族人权的特殊保护

对少数民族人权保护问题研究的重点,是少数民族人权的特殊保护(特殊权利或特殊保护措施)问题,但研究还十分薄弱。系统地认识国际人权立法与实践中关于少数民族人权的特殊保护,对我国少数民族人权保护有着重要的借鉴意义。本文从少数民族人权特殊保护的涵义、必要性、特殊权利、国家义务、特殊保护的限度、特殊权利的限制和克减等方面展开分析和论述。