Another look at the robustness of colton's model for comparing two medical treatments

The robustness of an extended version of Colton's decision theoretic model is considered. The extended version includes the losses due to the patients who are not entered in the experiment, but require treatment while the experiment is in progress. Among the topics considered are the effects of risk of using a sample size considerably less than the optimum, use of an incorrect patient horizon, application of a modified loss function, and use of a two point prior distribution. It is shown that the investigated model is robust with respect to all these changes with the exception of the use of the modified prior density.     

Extremum sieve estimation in k-out-of-n systems

This article considers the non parametric estimation of absolutely continuous distribution functions of independent lifetimes of non identical components in k-out-of-n systems, 2 ? k ? n, from the observed “autopsy” data. In economics, ascending “button” or “clock” auctions with n heterogeneous bidders with independent private values present 2-out-of-n systems. Classical competing risks models are examples of n-out-of-n systems. Under weak conditions on the underlying distributions, the estimation problem is shown to be well-posed and the suggested extremum sieve estimator is proven to be consistent. This article considers the sieve spaces of Bernstein polynomials which allow to easily implement constraints on the monotonicity of estimated distribution functions.     

Modelling of connected processes

The problem of comparing, contrasting and combining information from different sets of data is an enduring one in many practical applications of statistics. A specific problem of combining information from different sources arose in integrating information from three different sets of data generated by three different sampling campaigns at the input stage as well as at the output stage of a grey-water treatment process. For each stage, a common process trend function needs to be estimated to describe the input and output material process behaviours. Once the common input and output process models are established, it is required to estimate the efficiency of the grey-water treatment method. A synthesized tool for modelling different sets of process data is created by assembling and organizing a number of existing techniques: (i) a mixed model of fixed and random effects, extended to allow for a nonlinear fixed effect, (ii) variogram modelling, a geostatistical technique, (iii) a weighted least squares regression embedded in an iterative maximum-likelihood technique to handle linear/nonlinear fixed and random effects and (iv) a formulation of a transfer-function model for the input and output processes together with a corresponding nonlinear maximum-likelihood method for estimation of a transfer function. The synthesized tool is demonstrated, in a new case study, to contrast and combine information from connected process models and to determine the change in one quality characteristic, namely pH, of the input and output materials of a grey-water filtering process.     

The generalized odd half-Cauchy family of distributions: Properties and applications

We introduce and study general mathematical properties of a new generator of continuous distributions with one extra parameter called the generalized odd half-Cauchy family. We present some special models and investigate the asymptotics and shapes. The new density function can be expressed as a linear mixture of exponentiated densities based on the same baseline distribution. We derive a power series for the quantile function. We discuss the estimation of the model parameters by maximum likelihood and prove empirically the flexibility of the new family by means of two real data sets.     

A comparative study of confidence intervals for negative binomial proportion

In this paper, we investigate four existing and three new confidence interval estimators for the negative binomial proportion (i.e., proportion under inverse/negative binomial sampling). An extensive and systematic comparative study among these confidence interval estimators through Monte Carlo simulations is presented. The performance of these confidence intervals are evaluated in terms of their coverage probabilities and expected interval widths. Our simulation studies suggest that the confidence interval estimator based on saddlepoint approximation is more appealing for large coverage levels (e.g., nominal level≤1% ) whereas the score confidence interval estimator is more desirable for those commonly used coverage levels (e.g., nominal level>1% ). We illustrate these confidence interval construction methods with a real data set from a maternal congenital heart disease study.     

Numerical evaluation of tests based on different heteroskedasticity-consistent covariance matrix estimators

This article considers the issue of performing tests in linear heteroskedastic models when the test statistic employs a consistent variance estimator. Several different estimators are considered, namely: HC0, HC1, HC2, HC3, and their bias-adjusted versions. The numerical evaluation is performed using numerical integration methods; the Imhof algorithm is used to that end. The results show that bias-adjustment of variance estimators used to construct test statistics delivers more reliable tests when they are performed for the HC0 and HC1 estimators, but the same does not hold for the HC3 estimator. Overall, the most reliable test is the HC3-based one.     

Affiliation networks with an increasing degree sequence

Affiliation network is one kind of two-mode social network with two different sets of nodes (namely, a set of actors and a set of social events) and edges representing the affiliation of the actors with the social events. Although a number of statistical models are proposed to analyze affiliation networks, the asymptotic behaviors of the estimator are still unknown or have not been properly explored. In this article, we study an affiliation model with the degree sequence as the exclusively natural sufficient statistic in the exponential family distributions. We establish the uniform consistency and asymptotic normality of the maximum likelihood estimator when the numbers of actors and events both go to infinity. Simulation studies and a real data example demonstrate our theoretical results.     

Semi-empirical likelihood inference for the ROC curve with missing data

The receiver operating characteristic (ROC) curve is one of the most commonly used methods to compare the diagnostic performance of two or more laboratory or diagnostic tests. In this paper, we propose semi-empirical likelihood based confidence intervals for ROC curves of two populations, where one population is parametric and the other one is non-parametric and both have missing data. After imputing missing values, we derive the semi-empirical likelihood ratio statistic and the corresponding likelihood equations. It is shown that the log-semi-empirical likelihood ratio statistic is asymptotically scaled chi-squared. The estimating equations are solved simultaneously to obtain the estimated lower and upper bounds of semi-empirical likelihood confidence intervals. We conduct extensive simulation studies to evaluate the finite sample performance of the proposed empirical likelihood confidence intervals with various sample sizes and different missing probabilities.     

Fitting the generalized lambda distribution to pre-binned data

Density estimation for pre-binned data is challenging due to the loss of exact position information of the original observations. Traditional kernel density estimation methods cannot be applied when data are pre-binned in unequally spaced bins or when one or more bins are semi-infinite intervals. We propose a novel density estimation approach using the generalized lambda distribution (GLD) for data that have been pre-binned over a sequence of consecutive bins. This method enjoys the high power of the parametric model and the great shape flexibility of the GLD. The performances of the proposed estimators are benchmarked via simulation studies. Both simulation results and a real data application show that the proposed density estimators work well for data of moderate or large sizes.     

The Kumaraswamy GEV distribution

The popular generalized extreme value (GEV) distribution has not been a flexible model for extreme values in many areas. We propose a generalization – referred to as the Kumaraswamy GEV distribution – and provide a comprehensive treatment of its mathematical properties. We estimate its parameters by the method of maximum likelihood and provide the observed information matrix. An application to some real data illustrates flexibility of the new model. Finally, some bivariate generalizations of the model are proposed.