Comparing search and estimation performances of designs based on a compound criterion

Since the introduction of the search design by Srivastava [Designs for searching non-negligible effects. In: Srivastava, editor. A survey of statistical design and linear models. Amsterdam: North-Holland, Elsevier; 1975. p. 507–519], construction of such designs has been considered by many researchers. The efficient performances of constructed search designs in terms of parameter estimation and search ability of parameters have also been investigated by several authors. They have proposed suitable optimality measures such as DD- and AD-optimality for estimation in the early stage of search design construction. Moreover, since 1990s, some criteria have been developed to evaluate search performance of a design. Although these criteria are useful none of them is able to evaluate both estimation and search efficiency of a design simultaneously. In this paper, we propose dual-task criteria to deal with searching and estimating performances of search designs. These compound criteria are weighted multiplication of estimation and search suitable criteria. They will be used for design comparison and the results will be presented.     

Penalized contrast estimation in functional linear models with circular data

Our aim is to estimate the unknown slope function in the functional linear model when the response Y is real and the random function X is a second-order stationary and periodic process. We obtain our estimator by minimizing a standard (and very simple) mean-square contrast on linear finite dimensional spaces spanned by trigonometric bases. Our approach provides a penalization procedure which allows to automatically select the adequate dimension, in a non-asymptotic point of view. In fact, we can show that our penalized estimator reaches the optimal (minimax) rate of convergence in the sense of the prediction error. We complete the theoretical results by a simulation study and a real example that illustrates how the procedure works in practice.     

Bayesian adaptive dose‐escalation procedures for binary and continuous responses utilizing a gain function

One of the main aims of early phase clinical trials is to identify a safe dose with an indication of therapeutic benefit to administer to subjects in further studies. Ideally therefore, dose‐limiting events (DLEs) and responses indicative of efficacy should be considered in the dose‐escalation procedure. Several methods have been suggested for incorporating both DLEs and efficacy responses in early phase dose‐escalation trials. In this paper, we describe and evaluate a Bayesian adaptive approach based on one binary response (occurrence of a DLE) and one continuous response (a measure of potential efficacy) per subject. A logistic regression and a linear log‐log relationship are used respectively to model the binary DLEs and the continuous efficacy responses. A gain function concerning both the DLEs and efficacy responses is used to determine the dose to administer to the next cohort of subjects. Stopping rules are proposed to enable efficient decision making. Simulation results shows that our approach performs better than taking account of DLE responses alone. To assess the robustness of the approach, scenarios where the efficacy responses of subjects are generated from an E _max model, but modelled by the linear log–log model are also considered. This evaluation shows that the simpler log–log model leads to robust recommendations even under this model showing that it is a useful approximation to the difficulty in estimating E _max model. Additionally, we find comparable performance to alternative approaches using efficacy and safety for dose‐finding. Copyright © 2015 John Wiley & Sons, Ltd.     

Strategic Intersectionality and Political Representation: Female Muslim Councilors in London

This article addresses questions of how race/ethnicity, gender, and religion influence political representation. We use original interview data to test a strategic intersectionality theory developed by Fraga and colleagues (2005) in the case of female Muslim councilors in London, the United Kingdom. The original strategic intersectionality theory proposes that women are more effective advocates for ethnic group interests due to their unique capacity to leverage three primary resources: a substantive policy focus, multiple identity advantage, and gender inclusive advantage. We modify the thesis by analyzing religion as an additional identity marker and further disaggregating the three primary sources of leverage. We use the modified thesis to test whether female Muslim councilors of three London boroughs are more effective advocates for Muslim interests than their non-Muslim colleagues. We find mixed evidence for the presence of the three sources of leverage associated with strategic intersectionality, resulting in a more complex theorizing of this phenomenon than that found in prior research. This study offers a new contribution to the operationalization of intersectionality and the literature on intersectionality and political representation.     

基于加权案例推理模型族的软件成本SVR组合估算

精确地估算软件成本是软件项目成功开发的一个重要保证,直接影响着软件的风险控制和质量保证.为了更好地解决单一估算模型的不足,提出了集成多案例推理(CBR)模型的软件成本组合估算模型.首先,采用六种距离计算公式刻画新旧项目相似度,构建了六种CBR模型,并运用粒子群算法(PSO)来优化CBR模型族中的属性权重.其次,在CBR模型族的基础上,运用支持向量回归机(SVR)模型将不同CBR模型的估算结果进行集成,提高软件成本估算结果的精度.利用Deshamais数据库对模型有效性进行检验,实证结果表明,在六种CBR模型中Euc-CBR、Min-CBR、Gau-CBR和Mah-CBR模型估算结果没有明显差异,Gre-CBR和Man-CBR模型略优;提出的SVR组合估算模型估算精度明显优于单CBR模型和其他线性组合估算模型,能有效提高软件成本的估算精度.     

Notes on estimation of the intraclass correlation under the AB/BA crossover trial

Under the AB/BA crossover trial, we focus our attention on estimation of the intraclass correlation in normal data. We develop both point and interval estimators in closed form for the intraclass correlation. We employ Monte Carlo simulation to study the performance of these estimators in a variety of situations. We note that the estimators developed here for the intraclass correlation remain valid even when there are possibly unexpected carry-over effects.     

Monitoring and change-point estimation for spline-modeled non-linear profiles in phase II

In some applications of statistical quality control, quality of a process or a product is best characterized by a functional relationship between a response variable and one or more explanatory variables. This relationship is referred to as a profile. In certain cases, the quality of a process or a product is better described by a non-linear profile which does not follow a specific parametric model. In these circumstances, nonparametric approaches with greater flexibility in modeling the complicated profiles are adopted. In this research, the spline smoothing method is used to model a complicated non-linear profile and the Hotelling T² control chart based on the spline coefficients is used to monitor the process. After receiving an out-of-control signal, a maximum likelihood estimator is employed for change point estimation. The simulation studies, which include both global and local shifts, provide appropriate evaluation of the performance of the proposed estimation and monitoring procedure. The results indicate that the proposed method detects large global shifts while it is very sensitive in detecting local shifts.     

New flexible models generated by gamma random variables for lifetime modeling

In this paper we introduce a new three-parameter exponential-type distribution. The new distribution is quite flexible and can be used effectively in modeling survival data and reliability problems. It can have constant, decreasing, increasing, upside-down bathtub and bathtub-shaped hazard rate functions. It also generalizes some well-known distributions. We discuss maximum likelihood estimation of the model parameters for complete sample and for censored sample. Additionally, we formulate a new cure rate survival model by assuming that the number of competing causes of the event of interest has the Poisson distribution and the time to this event follows the proposed distribution. Maximum likelihood estimation of the model parameters of the new cure rate survival model is discussed for complete sample and censored sample. Two applications to real data are provided to illustrate the flexibility of the new model in practice.     

Adaptive Warped Kernel Estimators

In this work, we develop a method of adaptive non‐parametric estimation, based on ‘warped’ kernels. The aim is to estimate a real‐valued function s from a sample of random couples (X,Y). We deal with transformed data (Φ(X),Y), with Φ a one‐to‐one function, to build a collection of kernel estimators. The data‐driven bandwidth selection is performed with a method inspired by Goldenshluger and Lepski (Ann. Statist., 39, 2011, 1608). The method permits to handle various problems such as additive and multiplicative regression, conditional density estimation, hazard rate estimation based on randomly right‐censored data, and cumulative distribution function estimation from current‐status data. The interest is threefold. First, the squared‐bias/variance trade‐off is automatically realized. Next, non‐asymptotic risk bounds are derived. Lastly, the estimator is easily computed, thanks to its simple expression: a short simulation study is presented.