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131.
《Omega》2015
We study an Inventory Routing Problem in which the supplier has a limited production capacity and the stochastic demand of the retailers is satisfied with procurement of transportation services. The aim is to minimize the total expected cost over a planning horizon, given by the sum of the inventory cost at the supplier, the inventory cost at the retailers, the penalty cost for stock-out at the retailers and the transportation cost. First, we show that a policy based just on the average demand can have a total expected cost infinitely worse than the one obtained by taking into account the overall probability distribution of the demand in the decision process. Therefore, we introduce a stochastic dynamic programming formulation of the problem that allows us to find an optimal policy in small size instances. Finally, we design and implement a matheuristic approach, integrating a rollout algorithm and an optimal solution of mixed-integer linear programming models, which is able to solve realistic size problem instances. Computational results allow us to provide managerial insights concerning the management of stochastic demand. 相似文献
132.
Concordance correlation coefficient (CCC) is one of the most popular scaled indices used to evaluate agreement. Most commonly, it is used under the assumption that data is normally distributed. This assumption, however, does not apply to skewed data sets. While methods for the estimation of the CCC of skewed data sets have been introduced and studied, the Bayesian approach and its comparison with the previous methods has been lacking. In this study, we propose a Bayesian method for the estimation of the CCC of skewed data sets and compare it with the best method previously investigated. The proposed method has certain advantages. It tends to outperform the best method studied before when the variation of the data is mainly from the random subject effect instead of error. Furthermore, it allows for greater flexibility in application by enabling incorporation of missing data, confounding covariates, and replications, which was not considered previously. The superiority of this new approach is demonstrated using simulation as well as real‐life biomarker data sets used in an electroencephalography clinical study. The implementation of the Bayesian method is accessible through the Comprehensive R Archive Network. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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本文首先对产业集群研究的历史进行了回顾 ,列举了产业集群促进区域经济发展的若干实例。通过对江西星火工业园有机硅产业集群案例的实证分析揭示了产业集群的形成因素 ,探讨了地方政府在集群规划中的作用 ,并提出了地方政府应该采取的若干对策 相似文献
135.
为解决有限的学习时间与知识爆炸之间的矛盾,从教学本质出发,将PBL教育理念在数学建模课程的教与学方面进行了实践,并将实践结果与传统模式下的教学进行对照,发现以PBL教育理念为指导的教与学不仅能够激发学生的学习兴趣,而且有利于形成学生的创新思维与创新能力。 相似文献
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Whether crystalline silica (CS) exposure increases risk of lung cancer in humans without silicosis, and, if so, whether the exposure‐response relation has a threshold, have been much debated. Epidemiological evidence is ambiguous and conflicting. Experimental data show that high levels of CS cause lung cancer in rats, although not in other species, including mice, guinea pigs, or hamsters; but the relevance of such animal data to humans has been uncertain. This article applies recent insights into the toxicology of lung diseases caused by poorly soluble particles (PSPs), and by CS in particular, to model the exposure‐response relation between CS and risk of lung pathologies such as chronic inflammation, silicosis, fibrosis, and lung cancer. An inflammatory mode of action is described, having substantial empirical support, in which exposure increases alveolar macrophages and neutrophils in the alveolar epithelium, leading to increased reactive oxygen species (ROS) and nitrogen species (RNS), pro‐inflammatory mediators such as TNF‐alpha, and eventual damage to lung tissue and epithelial hyperplasia, resulting in fibrosis and increased lung cancer risk among silicotics. This mode of action involves several positive feedback loops. Exposures that increase the gain factors around such loops can create a disease state with elevated levels of ROS, TNF‐alpha, TGF‐beta, alveolar macrophages, and neutrophils. This mechanism implies a “tipping point” threshold for the exposure‐response relation. Applying this new model to epidemiological data, we conclude that current permissible exposure levels, on the order of 0.1 mg/m3, are probably below the threshold for triggering lung diseases in humans. 相似文献
138.
线性规划中的灵敏度分析 总被引:1,自引:0,他引:1
考虑了线性规划模型中的灵敏度分析,解决了当约束条件减少时,最优解如何变化的问题。 相似文献
139.
《商业与经济统计学杂志》2013,31(1):169-180
We consider consistent tests for stochastic dominance efficiency at any order of a given portfolio with respect to all possible portfolios constructed from a set of assets. We justify block bootstrap approaches to achieve valid inference in a time series setting. The test statistics are computed using linear and mixed integer programming formulations. Monte Carlo results show that the bootstrap procedure performs well in finite samples. The empirical application reveals that the Fama and French market portfolio is first and second-order stochastic dominance efficient, although it is mean–variance inefficient. 相似文献
140.
Rajat Bhagwat 《生产规划与管理》2013,24(8):678-690
The performance measurement problem has gained great attention in business and operations management literature. The first objective of this study is to determine the required performance measures and to develop a model for performance evaluation, based on these selected measures using analytical hierarchy process (AHP) methodology. The second objective is to explain how an integrated AHP-PGP (pre-emptive goal programming) model can be used in performance measurement while optimising the overall performance. An integration of AHP and multi-objective PGP is used to consider both quantitative and qualitative performance measures in optimising the overall performance of the system. The integrated model is presented with a real-world application using source data provided by a survey conducted in India. Findings demonstrate that the integrated AHP-PGP model can be useful to all supply chain industries in their day-to-day performance measurement decisions. 相似文献