Low dose risk estimation via simultaneous statistical inferences

Summary.  The paper develops and studies simultaneous confidence bounds that are useful for making low dose inferences in quantitative risk analysis. Application is intended for risk assessment studies where human, animal or ecological data are used to set safe low dose levels of a toxic agent, but where study information is limited to high dose levels of the agent. Methods are derived for estimating simultaneous, one-sided, upper confidence limits on risk for end points measured on a continuous scale. From the simultaneous confidence bounds, lower confidence limits on the dose that is associated with a particular risk (often referred to as a bench-mark dose ) are calculated. An important feature of the simultaneous construction is that any inferences that are based on inverting the simultaneous confidence bounds apply automatically to inverse bounds on the bench-mark dose.     

BAYESIAN SUBSET SELECTION AND MODEL AVERAGING USING A CENTRED AND DISPERSED PRIOR FOR THE ERROR VARIANCE

This article proposes a new data‐based prior distribution for the error variance in a Gaussian linear regression model, when the model is used for Bayesian variable selection and model averaging. For a given subset of variables in the model, this prior has a mode that is an unbiased estimator of the error variance but is suitably dispersed to make it uninformative relative to the marginal likelihood. The advantage of this empirical Bayes prior for the error variance is that it is centred and dispersed sensibly and avoids the arbitrary specification of hyperparameters. The performance of the new prior is compared to that of a prior proposed previously in the literature using several simulated examples and two loss functions. For each example our paper also reports results for the model that orthogonalizes the predictor variables before performing subset selection. A real example is also investigated. The empirical results suggest that for both the simulated and real data, the performance of the estimators based on the prior proposed in our article compares favourably with that of a prior used previously in the literature.     

A note on interval‐censored lifetime data and the constant‐sum condition of oiler,gómez & calle (2004)

Oiler, Gomez & Calle (2004) give a constant sum condition for processes that generate interval‐censored lifetime data. They show that in models satisfying this condition, it is possible to estimate non‐parametrically the lifetime distribution based on a well‐known simplified likelihood. The author shows that this constant‐sum condition is equivalent to the existence of an observation process that is independent of lifetimes and which gives the same probability distribution for the observed data as the underlying true process.     

Direct and Indirect Causal Effects via Potential Outcomes*

Abstract. The use of the concept of ‘direct’ versus ‘indirect’ causal effects is common, not only in statistics but also in many areas of social and economic sciences. The related terms of ‘biomarkers’ and ‘surrogates’ are common in pharmacological and biomedical sciences. Sometimes this concept is represented by graphical displays of various kinds. The view here is that there is a great deal of imprecise discussion surrounding this topic and, moreover, that the most straightforward way to clarify the situation is by using potential outcomes to define causal effects. In particular, I suggest that the use of principal stratification is key to understanding the meaning of direct and indirect causal effects. A current study of anthrax vaccine will be used to illustrate ideas.     

数学证明中的推理问题

演绎推理和非演绎推理经常被运用到数学证明中。二者的共同之处在于:都是从前提推出结论、从已知达于未知;非演绎推理除归纳法之外,与演绎推理一样,只要前提都真,结论必真。不同之处在于:演绎推理从前提到结论之间的推理是逻辑推理,而非演绎推理的推理过程则是根据具体问题进行具体分析;演绎推理的前提与结论之间的关系必然能被数理逻辑的逻辑演算中的形式定理所反映,非演绎推理的前提与结论间的关系则不能;演绎推理对应着一个演绎推理规则,非演绎推理则无对应的推理规则。     

Weak disintegrability as a form of preservation of coherence

Summary Weak disintegrations are investigated from various points of view. Kolmogorov's definition of conditional probability is critically analysed, and it is noted how the notion of disintegrability plays some role in connecting Kolmogorov's definition with the one given in line with de Finetti's coherence principle. Conditions are given, on the domain of a prevision, implying the equivalence between weak disintegrability and conglomerability. Moreover, weak sintegrations are characterized in terms of coherence, in de Finetti's sense, of, a suitable function. This fact enables us to give, an interpretation of weak disintegrability as a form of “preservation of coherence”. The previous results are also applied to a hypothetical inferential problem. In particular, an inference is shown to be coherent, in the sense of Heath and Sudderth, if and only if a suitable function is coherent, in de Finetti's sense. Research partially supported by: M.U.R.S.T. 40% “Problemi di inferenza pura”.     

基于贝叶斯神经网络的非参数回归

提高神经网络模型推广能力的关键是控制模型的复杂度。该文探索了贝叶斯神经网络的非参数回归的建模方法,通过融入模型参数的先验知识,在给定数据样本及模型假设下进行后验概率的贝叶斯推理,使用马尔可夫链蒙特卡罗算法来优化模型控制参数,实现了对神经网络模型中不同部分复杂度的控制,获得了模型参数的后验分布及预测分布。在5个含噪二维函数回归问题上的应用显示了模型的复杂度能根据数据的复杂度而自适应调整,并给出了较好的预测结果。     

Conditions for Non-confounding and Collapsibility without Knowledge of Completely Constructed Causal Diagrams

In this paper, we discuss several concepts in causal inference in terms of causal diagrams proposed by Pearl (1993 , 1995a , b ), and we give conditions for non-confounding, homogeneity and collapsibility for causal effects without knowledge of a completely constructed causal diagram. We first introduce the concepts of non-confounding, conditional non-confounding, uniform non-confounding, homogeneity, collapsibility and strong collapsibility for causal effects, then we present necessary and sufficient conditions for uniform non-confounding, homegeneity and collapsibilities, and finally we show sufficient conditions for non-confounding, conditional non-confounding and uniform non-confounding.     

语篇理解过程及其心理机制

从认知心理学、心理语言学角度讨论了语篇理解的过程及其心理机制。首先从命题、推断、局部与整体连贯三个层次上讨论了语篇理解的认知过程 ;然后从认知构件、认知理解模式对认知结构的模拟以及语篇处理过程中的资源限制三个维度论述了语篇理解的心理机制。文章最后指出 ,语篇理解研究的进一步深化取决于研究方法的改进和研究领域的拓展     

Optimal sampling for repeated binary measurements

The authors consider the optimal design of sampling schedules for binary sequence data. They propose an approach which allows a variety of goals to be reflected in the utility function by including deterministic sampling cost, a term related to prediction, and if relevant, a term related to learning about a treatment effect To this end, they use a nonparametric probability model relying on a minimal number of assumptions. They show how their assumption of partial exchangeability for the binary sequence of data allows the sampling distribution to be written as a mixture of homogeneous Markov chains of order k. The implementation follows the approach of Quintana & Müller (2004), which uses a Dirichlet process prior for the mixture.