Adaptive and repeated cumulative meta‐analyses of safety data during a new drug development process

During a new drug development process, it is desirable to timely detect potential safety signals. For this purpose, repeated meta‐analyses may be performed sequentially on accumulating safety data. Moreover, if the amount of safety data from the originally planned program is not enough to ensure adequate power to test a specific hypothesis (e.g., the noninferiority hypothesis of an event of interest), the total sample size may be increased by adding new studies to the program. Without appropriate adjustment, it is well known that the type I error rate will be inflated because of repeated analyses and sample size adjustment. In this paper, we discuss potential issues associated with adaptive and repeated cumulative meta‐analyses of safety data conducted during a drug development process. We consider both frequentist and Bayesian approaches. A new drug development example is used to demonstrate the application of the methods. Copyright © 2015 John Wiley & Sons, Ltd.     

Another Remark on the Alternative Expectation Formula

Students in a calculus-based probability course will often see the expectation formula for nonnegative continuous random variables in terms of the survival function. This alternative expectation formula has a wide spectrum of applications. It is natural to ask whether there is a multivariate version of this formula. This note gives an affirmative answer by establishing such a formula using two different approaches. The two approaches employed in this note correspond to the two approaches for the univariate case. Supplementary materials for this article are available online.     

Estimation of finite population mean in stratified sampling using scrambled responses in the presence of measurement errors

This study focuses on the estimation of population mean of a sensitive variable in stratified random sampling based on randomized response technique (RRT) when the observations are contaminated by measurement errors (ME). A generalized estimator of population mean is proposed by using additively scrambled responses for the sensitive variable. The expressions for the bias and mean square error (MSE) of the proposed estimator are derived. The performance of the proposed estimator is evaluated both theoretically and empirically. Results are also applied to a real data set.     

A new look at clustering coefficients with generalization to weighted and multi-faction networks

In this paper we propose a new method for studying local and global clustering in networks employing random walk pairs. The method is intuitive and directly generalizes standard local and global clustering coefficients to weighted networks and networks containing nodes of multiple types. In the case of two-mode networks the values obtained for commonly considered social networks are in sharp contrast to those obtained, for instance, by the method of Opsahl (2013), and provide a different viewpoint for clustering. The approach is also applicable in questions related to the general study of segregation and homophily. Applications to existent data sets are considered.     

Analysis of a two incongruent arrivals and services M/G/1 queue with random feedback

A queuing system with two incongruent arrivals and services is considered. Two kinds of customers enter the system by Poisson process and the service times are assumed to have general distribution. After first kind service completion, it may feedback to repeat the first service, leave the system or go to give second service. The same policy is applied for the other kind of customer. All stochastic processes involved in this system are independent. We derive the probability generating function for each kind and for the system that yield the performance measures. Some numerical approaches examined the validity of the results.     

Extending public relationship-building through the theory of politeness

For more than thirty years, relationship-building has been recognized as central to public relations, and yet, exactly how practitioners go about building and maintaining relationships at the micro level has been insufficiently explored in public relations scholarship. Politeness, or a lack thereof, is ever-present in all communicative interactions, affecting the formation and development of relationships. There is therefore value in extending our understanding of how these relationships are impacted by (im)polite communicative acts. Principally, politeness attempts to balance participants’ face needs or needs for self-esteem through employing various strategies, and this article attempts to explicate the theory of politeness for public relations work. It concludes that an understanding of the fundamentals of politeness theory and strategies enables practitioners to be more effective at building relationships within and across communities, avoiding potential pragmatic failure.     

On approximate likelihood inference in a poisson mixed model

A two-step estimation approach is proposed for the fixed-effect parameters, random effects and their variance σ² of a Poisson mixed model. In the first step, it is proposed to construct a small σ²-based approximate likelihood function of the data and utilize this function to estimate the fixed-effect parameters and σ². In the second step, the random effects are estimated by minimizing their posterior mean squared error. Methods of Waclawiw and Liang (1993) based on so-called Stein-type estimating functions and of Breslow and Clayton (1993) based on penalized quasilikelihood are compared with the proposed likelihood method. The results of a simulation study on the performance of all three approaches are reported.     

Failure Inference From a Marker Process Based on a Bivariate Wiener Model

Many models have been proposed that relate failure times and stochastic time-varying covariates. In some of these models, failure occurs when a particular observable marker crosses a threshold level. We are interested in the more difficult, and often more realistic, situation where failure is not related deterministically to an observable marker. In this case, joint models for marker evolution and failure tend to lead to complicated calculations for characteristics such as the marginal distribution of failure time or the joint distribution of failure time and marker value at failure. This paper presents a model based on a bivariate Wiener process in which one component represents the marker and the second, which is latent (unobservable), determines the failure time. In particular, failure occurs when the latent component crosses a threshold level. The model yields reasonably simple expressions for the characteristics mentioned above and is easy to fit to commonly occurring data that involve the marker value at the censoring time for surviving cases and the marker value and failure time for failing cases. Parametric and predictive inference are discussed, as well as model checking. An extension of the model permits the construction of a composite marker from several candidate markers that may be available. The methodology is demonstrated by a simulated example and a case application.     

回归模型中异性方差问题的克服

提出了回归分析中异性方差的检验和对估计结果带来的影响以及消除其异方差性的两种方法：对原模型进行变换和加权最小二乘法．