Testing a censoring hypothesis through an identity test

Given two samples drawn from the same, unknown, population, it is assumed to be known that only one has possibly been censored and which one it is. A nonparametric procedure to test the no censoring null hypothesis against the alternative censoring hypothesis is discussed.     

A note on the satterthwaite confidence interval for a variance

When using a Satterthwaite chi-squared approximation, it is generally thought that the approximation is satisfactory when it is applied to a positive linear combination of mean squares. In this note, we describe how the Williams - Tukey idea for getting a confidence interval for the among groups variance in a random one-way model can be incorporated into Satterthwaite’s procedure for getting a confidence interval for a variance. This adjusted Satterthwaite procedure insures that his chi-squared approximation is always applied to positive linear combinations of mean squares. A small simulation is included which suggests that the adjustment to the Satterthwaite procedure is effective.     

Tests of association between survival time and a continuous covariate

Proportional hazards model(Cox, 1972) is reviewed for the case of grouped data with one continuously measured covariate. This leads to a logit-rank procedure for tied data which is reduced to the test proposed by O’Brien(1978) and studied by O’Quigley and Prentice(1991) in the absence of ties. The proposed test is then applied to a special ranking method in order to study non-monotonic associations.     

Three-stage designs for monitoring clinical trials

Optimal three-stage designs with equal sample sizes at each stage are presented and compared to fixed sample designs, fully sequential designs, designs restricted to use the fixed sample critical value at the final stage, and to modifications of other group sequential designs previously proposed in the literature. Typically, the greatest savings realized with interim analyses are obtained by the first interim look. More than 50% of the savings possible with a fully sequential design can be realized with a simple two-stage design. Three-stage designs can realize as much as 75% of the possible savings. Without much loss in efficiency, the designs can be modified so that the critical value at the final stage equals the usual fixed sample value while maintaining the overall level of significance, alleviating some potential confusion should a final stage be necessary. Some common group sequential designs, modified to allow early acceptance of the null hypothesis, are shown to be nearly optimal in some settings while performing poorly in others. An example is given to illustrate the use of several three-stage plans in the design of clinical trials.     

An alternative approach to variable selection for prediction

A procedure for selecting a subset of predictor variables in regression analysis is suggested. The procedure is so designed that it leads to the selection of a subset of variables having an adequate degree of informativeness with a directly specified confidence coefficient. Some examples are considered to illustrate the application of the procedure.     

On the level probabilities for useful partially ordered alternatives in the analysis of variance

In the analysis of variance, we often encounter situations in which we want to test the null hypothesis of homogeneity of the normal means against various partially ordered alternative hypotheses. We study likelihood ratio tests for three useful types of alternatives: d-star, bipartite and broom tree. Especially, we give computational formulas for the level probabilities of the alternative types. The results permit us to obtain critical values for practical use.     

Kullback-leibler information approach to the optimum measurement point for bayesian estimation

When an appropriate parametric model and a prior distribution of its parameters are given to describe clinical time courses of a dynamic biological process, Bayesian approaches allow us to estimate the entire profiles from a few or even a single observation per subject. The goodness of the estimation depends on the measurement points at which the observations were made. The number of measurement points per subject is generally limited to one or two. The limited measurement points have to be selected carefully. This paper proposes an approach to the selection of the optimum measurement point for Bayesian estimations of clinical time courses. The selection is made among given candidates, based on the goodness of estimation evaluated by the Kullback-Leibler information. This information measures the discrepancy of an estimated time course from the true one specified by a given appropriate model. The proposed approach is applied to a pharmacokinetic analysis, which is a typical clinical example where the selection is required. The results of the present study strongly suggest that the proposed approach is applicable to pharmacokinetic data and has a wide range of clinical applications.     

Sensitivity analysis for two control groups

In many experiments where data have been collected at two points in time (pre-treatment and post-treatment), investigators wish to determine if there is a difference between two treatment groups. In recent years it has been proposed that an appropriate statistical analysis to determine if treatment differences exist is to use the post-treatment values as the primary comparison variables and the pre-treatment values as covariates. When there are several outcome variables, we propose new tests based on residuals as alternatives to existing methods and investigate how the powers of the new and existing tests are affected by various choices of covariates. The limiting distribution of the test statistic of the new test based on residuals is given. Monte Carlo simulations are employed in the power comparisons.     

Umvu estimators for the population mean and variance based on random effects models for lognormal data

Cross-classified data are often obtained in controlled experimental situations and in epidemiologic studies. As an example of the latter, occupational health studies sometimes require personal exposure measurements on a random sample of workers from one or more job groups, in one or more plant locations, on several different sampling dates. Because the marginal distributions of exposure data from such studies are generally right-skewed and well-approximated as lognormal, researchers in this area often consider the use of ANOVA models after a logarithmic transformation. While it is then of interest to estimate original-scale population parameters (e.g., the overall mean and variance), standard candidates such as maximum likelihood estimators (MLEs) can be unstable and highly biased. Uniformly minimum variance unbiased (UMVU) cstiniators offer a viable alternative, and are adaptable to sampling schemes that are typiral of experimental or epidemiologic studies. In this paper, we provide UMVU estimators for the mean and variance under two random effects ANOVA models for logtransformed data. We illustrate substantial mean squared error gains relative to the MLE when estimating the mean under a one-way classification. We illustrate that the results can readily be extended to encompass a useful class of purely random effects models, provided that the study data are balanced.