Increasing the Power of the Test Through Pre-Test – A Robust Method

Robust test procedures are developed for testing the intercept of a simple regression model when the slope is (i) completely unspecified, (ii) specified to a fixed value, or (iii) suspected to be a fixed value. Defining (i) unrestricted (UT), (ii) restricted (RT), and (iii) pre-test test (PTT) functions for the intercept parameter under the three choices of the slope, tests are formulated using the M-estimation methodology. The asymptotic distributions of the test statistics and their asymptotic power functions are derived. The analytical and graphical comparisons of the tests reveal that the PTT achieves a reasonable dominance over the other tests.     

One-way ANOVA with Unequal Variances

We consider the one-way ANOVA problem of testing the equality of several normal means when the variances are not assumed to be equal. This is a generalization of the Behrens-Fisher problem, but even in this special case there is no exact test and the actual size of any test depends on the values of the nuisance parameters. Therefore, controlling the actual size of the test is of main concern. In this article, we first consider a test using the concept of generalized p-value. Extensive simulation studies show that the actual size of this test does not exceed the nominal level, for practically all values of the nuisance parameters, but the test is not too conservative either, in the sense that the actual size of the test can be very close to the nominal level for some values of the nuisance parameters. We then use this test to propose a simple F-test, which has similar properties but avoids the computations associated with generalized p-values. Because of its simplicity, both conceptually as well as computationally, this F-test may be more useful in practice, since one-way ANOVA is widely used by practitioners who may not be familiar with the generalized p-value and its computational aspects.     

Adaptive Hotelling's T 2 Control Charts with Run Rules

This study investigates the statistical properties of the adaptive Hotelling's T ² charts with run rules in which the sample size and sampling interval are allowed to vary according on the current and past sampling points. The adaptive charts include variable sample size (VSS), variable sampling interval (VSI), and variable sample size and sampling interval (VSSI) charts. The adaptive Hotelling's T ² charts with run rules are compared with the fixed sampling rate Hotelling's T ² chart with run rules. The numerical results show that the VSS, VSI, and VSSI features improve the performance of the Hotelling's T ² chart with run rules.     

Sample Size Determination and Rational Partition for A Multi- Regional Trial for Survival (Time-To-Event) Data with Unrecognized Heterogeneity that Interacts with Treatment

To shorten the drug lag or the time lag for approval, simultaneous drug development, submission, and approval in the world may be desirable. Recently, multi-regional trials have attracted much attention from sponsors as well as regulatory authorities. Current methods for sample determination are based on the assumption that true treatment effect is uniform across regions. However, unrecognized heterogeneity among patients as ethnic or genetic factor will effect patients’ survival. In this article, we address the issue that the treatment effects with unrecognized heterogeneity that interacts with treatment are among regions to design a multi-regional trial. The log-rank test is employed to deal with the heterogeneous effect size among regions. The test statistic for the overall treatment effect is used to determine the total sample size for a multi-regional trial and the consistent trend is used to rationalize partition for sample size to each region.     

Some theoretical results concerning non parametric estimation by using a judgment poststratification sample

ABSTRACT

In this paper, some of the properties of non parametric estimation of the expectation of g(X) (any function of X), by using a judgment poststratification sample (JPS), have been discussed. A class of estimators (including the standard JPS estimator and a JPS estimator proposed by Frey and Feeman (2012 Frey, J., Feeman, T.G. (2012). An improved mean estimator for judgment post-stratification. Comput. Stat. Data Anal. 56(2):418–426.[Crossref], [Web of Science ®] , [Google Scholar], Comput. Stat. Data An.) is considered. The paper provides mean and variance of the members of this class, and examines their consistency and asymptotic distribution. Specifically, the results are for the estimation of population mean, population variance, and cumulative distribution function. We show that any estimators of the class may be less efficient than simple random sampling (SRS) estimator for small sample sizes. We prove that the relative efficiency of some estimators in the class with respect to balanced ranked set sampling (BRSS) estimator tends to 1 as the sample size goes to infinity. Furthermore, the standard JPS mean estimator, and Frey–Feeman JPS mean estimator are specifically studied and we show that two estimators have the same asymptotic distribution. For the standard JPS mean estimator, in perfect ranking situations, optimum values of H (the ranking class size), for different sample sizes, are determined non parametrically for populations that are not heavily skewed or thick tailed.     

Fixed width confidence intervals for the location parameter of an exponential distribution

We study confidence intervals of prescribed width for the lo-cation parameter of an exponential distribution. Asymptotic expan-sions up to terms tending to zero are obtained for the coverage probability and expected sample size. The limiting distribution of the sample size is given from which an asymptotic expression for the variance of the sample size is deduced. Sequential procedures with non-asymptotic coverage probability are also investigated     

Conditional probability of correct selection under the continuum partition with applications

The problem of selecting the best population from among a finite number of populations in the presence of uncertainty is a problem one faces in many scientific investigations, and has been studied extensively, Many selection procedures have been derived for different selection goals. However, most of these selection procedures, being frequentist in nature, don't tell how to incorporate the information in a particular sample to give a data-dependent measure of correct selection achieved for this particular sample. They often assign the same decision and probability of correct selection for two different sample values, one of which actually seems intuitively much more conclusive than the other. The methodology of conditional inference offers an approach which achieves both frequentist interpret ability and a data-dependent measure of conclusiveness. By partitioning the sample space into a family of subsets, the achieved probability of correct selection is computed by conditioning on which subset the sample falls in. In this paper, the partition considered is the so called continuum partition, while the selection rules are both the fixed-size and random-size subset selection rules. Under the distributional assumption of being monotone likelihood ratio, results on least favourable configuration and alpha-correct selection are established. These re-sults are not only useful in themselves, but also are used to design a new sequential procedure with elimination for selecting the best of k Binomial populations. Comparisons between this new procedure and some other se-quential selection procedures with regard to total expected sample size and some risk functions are carried out by simulations.     

A fitted test for the behrens-fisher problem

In 1975, Lee and Gurland proposed a solution to the Behrens-Fisher problem. It had excellent control of size and power and was relatively simple to use. However it requires extensive special tables. This article proposes a modification of this approach. It replaces the tables with easily computed functions of the sample sizes and a standard t table. Control of size and power are equivalent to that obtained by Lee and Gurland. Furthermore, the test is also compared with the Welch's approximate t test and shows better control of size, with similar power curves when sample sizes are at least four from each of the two normal populations.     

On the performance of the nearest proportional to size sampling design

Assuming a super-population model the expected variance of the generalized difference estimator (Basu,1971) based on the nearest proportional to size sampling design introduced by Gabler(1987) is shown to be less than that of the same estimator based on an arbitrary sampling design from which the former design is realized. The former strategy is also shown to fare better than an unbiased ratio-cum-generalized difference estimator based on the nearest proportional to size sampling design in the sense of having less expected design variance under the same model.