Parameterization and inference for nonparametric regression problems

We consider local likelihood or local estimating equations, in which a multivariate function () is estimated but a derived function () of () is of interest. In many applications, when most naturally formulated the derived function is a non-linear function of (). In trying to understand whether the derived non-linear function is constant or linear, a problem arises with this approach: when the function is actually constant or linear, the expectation of the function estimate need not be constant or linear, at least to second order. In such circumstances, the simplest standard methods in nonparametric regression for testing whether a function is constant or linear cannot be applied. We develop a simple general solution which is applicable to nonparametric regression, varying-coefficient models, nonparametric generalized linear models, etc. We show that, in local linear kernel regression, inference about the derived function () is facilitated without a loss of power by reparameterization so that () is itself a component of (). Our approach is in contrast with the standard practice of choosing () for convenience and allowing ()> to be a non-linear function of (). The methods are applied to an important data set in nutritional epidemiology.     

Testing spatial randomness based on empirical distribution function: A study on lattice data

In this article, we extended the empirical distribution function based test statistic _Ik$I_k$ of Skaug and Tjostheim [1993. Nonparametric test of serial independence based on the empirical distribution function. Biometrika 80, 591–602] in the time series setting to _Dn$D_n$ for spatial lattice data and derived the asymptotic distribution of the proposed test statistic _Dn$D_n$ under the null hypothesis of spatial independence. The size and power of the proposed test statistic under conditional autoregressive model (CAR) were simulated. We applied _Dn$D_n$, Moran's I and Geary's c   to the transformed and well-studied sudden infant death syndrome data from North Carolina and found that _Dn$D_n$ produced a much smaller p$p$-value in testing spatial independence.     

Using the Standardized Difference to Compare the Prevalence of a Binary Variable Between Two Groups in Observational Research

Researchers are increasingly using the standardized difference to compare the distribution of baseline covariates between treatment groups in observational studies. Standardized differences were initially developed in the context of comparing the mean of continuous variables between two groups. However, in medical research, many baseline covariates are dichotomous. In this article, we explore the utility and interpretation of the standardized difference for comparing the prevalence of dichotomous variables between two groups. We examined the relationship between the standardized difference, and the maximal difference in the prevalence of the binary variable between two groups, the relative risk relating the prevalence of the binary variable in one group compared to the prevalence in the other group, and the phi coefficient for measuring correlation between the treatment group and the binary variable. We found that a standardized difference of 10% (or 0.1) is equivalent to having a phi coefficient of 0.05 (indicating negligible correlation) for the correlation between treatment group and the binary variable.     

Transformed Logit Confidence Intervals for Small Populations in Single Capture–Recapture Estimation

The good performance of logit confidence intervals for the odds ratio with small samples is well known. This is true unless the actual odds ratio is very large. In single capture–recapture estimation the odds ratio is equal to 1 because of the assumption of independence of the samples. Consequently, a transformation of the logit confidence intervals for the odds ratio is proposed in order to estimate the size of a closed population under single capture–recapture estimation. It is found that the transformed logit interval, after adding .5 to each observed count before computation, has actual coverage probabilities near to the nominal level even for small populations and even for capture probabilities near to 0 or 1, which is not guaranteed for the other capture–recapture confidence intervals proposed in statistical literature. Thus, given that the .5 transformed logit interval is very simple to compute and has a good performance, it is appropriate to be implemented by most users of the single capture–recapture method.     

A note on approximate confidence limits for the negative binomial model

Four methods of approximating confidence limits for the single negative binomial parameter, P, are outlined and an empirical study is presented. Some remarks on prediction intervals are also included.     

Case–control genome-wide joint association study using semiparametric empirical model and approximate Bayes factor

We propose a semiparametric approach for the analysis of case–control genome-wide association study. Parametric components are used to model both the conditional distribution of the case status given the covariates and the distribution of genotype counts, whereas the distribution of the covariates are modelled nonparametrically. This yields a direct and joint modelling of the case status, covariates and genotype counts, and gives a better understanding of the disease mechanism and results in more reliable conclusions. Side information, such as the disease prevalence, can be conveniently incorporated into the model by an empirical likelihood approach and leads to more efficient estimates and a powerful test in the detection of disease-associated SNPs. Profiling is used to eliminate a nuisance nonparametric component, and the resulting profile empirical likelihood estimates are shown to be consistent and asymptotically normal. For the hypothesis test on disease association, we apply the approximate Bayes factor (ABF) which is computationally simple and most desirable in genome-wide association studies where hundreds of thousands to a million genetic markers are tested. We treat the approximate Bayes factor as a hybrid Bayes factor which replaces the full data by the maximum likelihood estimates of the parameters of interest in the full model and derive it under a general setting. The deviation from Hardy–Weinberg Equilibrium (HWE) is also taken into account and the ABF for HWE using cases is shown to provide evidence of association between a disease and a genetic marker. Simulation studies and an application are further provided to illustrate the utility of the proposed methodology.     

An Adaptive Test for the Two-Sample Location Problem Based on U-Statistics

For the two-sample location problem with continuous data we consider a general class of tests, all members of it are based on U-statistics. The asymptotic efficacies are investigated in detail. We construct an adaptive test where all statistics involved are suitably chosen U-statistics. It is shown that the proposed adaptive test has good asymptotic and finite sample power properties.     

Use of several auxiliary variables in estimating the population mean in a two-occasion rotation pattern

ABSTRACT

This paper addresses the problem of estimation of the population mean on the current (second) occasion in two-occasion successive sampling. Utilizing the readily available information on several auxiliary variables on both occasions and the information on the study variable from the previous occasion, an estimation procedure of the population mean on the current occasion has been proposed. Theoretical properties of the proposed estimator have been investigated. Optimum replacement policy to the proposed estimator has been discussed. The proposed estimator has been compared empirically with the sample mean estimator, when there is no matching and the optimum estimator which is a linear combination of the means of the matched and unmatched portions of the sample at the current occasion. Appropriate recommendations have been made for practical applications.     

Comparing a New Gini Test with Other Symmetry Tests When Median Is Unknown

Although there exists an ample literature on the tests of univariate symmetry, each article provides comparison of few selected competitors only. We are comparing the performance of 15 tests recommended in the literature and two new methods introduced by Auda (2006 Auda (Ouda), H. 2006. New Tests of Univariate Symmetry Based on the Gini Mean Difference, Kalamazoo, MI: Western Michigan University. Ph.D. thesis [Google Scholar]). One of them, rank-based test RS, compares favorably with several existing procedures in controlling the Type I error as well as in power as shown in our comprehensive simulation study. An important novelty in the article are Figs. 1– 3 enabling comparison of Type I error probabilities and power of the 16 tests for 17 null and 19 alternative distributions.     

Sample Size Calculation and Blinded Sample Size Recalculation in Clinical Trials Where the Treatment Effect is Measured by the Relative Risk

In clinical trials with binary endpoints, the required sample size does not depend only on the specified type I error rate, the desired power and the treatment effect but also on the overall event rate which, however, is usually uncertain. The internal pilot study design has been proposed to overcome this difficulty. Here, nuisance parameters required for sample size calculation are re-estimated during the ongoing trial and the sample size is recalculated accordingly. We performed extensive simulation studies to investigate the characteristics of the internal pilot study design for two-group superiority trials where the treatment effect is captured by the relative risk. As the performance of the sample size recalculation procedure crucially depends on the accuracy of the applied sample size formula, we firstly explored the precision of three approximate sample size formulae proposed in the literature for this situation. It turned out that the unequal variance asymptotic normal formula outperforms the other two, especially in case of unbalanced sample size allocation. Using this formula for sample size recalculation in the internal pilot study design assures that the desired power is achieved even if the overall rate is mis-specified in the planning phase. The maximum inflation of the type I error rate observed for the internal pilot study design is small and lies below the maximum excess that occurred for the fixed sample size design.