Confidence intervals on p(y < x) for small sample sizes

When F = G^a, confidence intervals are derived and presented in graphs for p = P(Y < X), when X and Y are independent and the sample sizes are at most 25. Also, it is demonstrated via a monte carlo simulation that this is a robust procedure, when the distributions of X and Y differ by a location parameter.     

A note on approximate confidence limits for the negative binomial model

Four methods of approximating confidence limits for the single negative binomial parameter, P, are outlined and an empirical study is presented. Some remarks on prediction intervals are also included.     

Prediction Techniques for Box–Cox Regression Models

This article reviews several techniques useful for forming point and interval predictions in regression models with Box-Cox transformed variables. The techniques reviewed—plug-in, mean squared error analysis, predictive likelihood, and stochastic simulation—take account of nonnormality and parameter uncertainty in varying degrees. A Monte Carlo study examining their small-sample accuracy indicates that uncertainty about the Box–Cox transformation parameter may be relatively unimportant. For certain parameters, deterministic point predictions are biased, and plug-in prediction intervals are also biased. Stochastic simulation, as usually carried out, leads to badly biased predictions. A modification of the usual approach renders stochastic simulation predictions largely unbiased.     

Simulation of the p-generalized Gaussian distribution

In this paper, we introduce the p-generalized polar methods for the simulation of the p-generalized Gaussian distribution. On the basis of geometric measure representations, the well-known Box–Muller method and the Marsaglia–Bray rejecting polar method for the simulation of the Gaussian distribution are generalized to simulate the p-generalized Gaussian distribution, which fits much more flexibly to data than the Gaussian distribution and has already been applied in various fields of modern sciences. To prove the correctness of the p-generalized polar methods, we give stochastic representations, and to demonstrate their adequacy, we perform a comparison of six simulation techniques w.r.t. the goodness of fit and the complexity. The competing methods include adapted general methods and another special method. Furthermore, we prove stochastic representations for all the adapted methods.     

Case–control genome-wide joint association study using semiparametric empirical model and approximate Bayes factor

We propose a semiparametric approach for the analysis of case–control genome-wide association study. Parametric components are used to model both the conditional distribution of the case status given the covariates and the distribution of genotype counts, whereas the distribution of the covariates are modelled nonparametrically. This yields a direct and joint modelling of the case status, covariates and genotype counts, and gives a better understanding of the disease mechanism and results in more reliable conclusions. Side information, such as the disease prevalence, can be conveniently incorporated into the model by an empirical likelihood approach and leads to more efficient estimates and a powerful test in the detection of disease-associated SNPs. Profiling is used to eliminate a nuisance nonparametric component, and the resulting profile empirical likelihood estimates are shown to be consistent and asymptotically normal. For the hypothesis test on disease association, we apply the approximate Bayes factor (ABF) which is computationally simple and most desirable in genome-wide association studies where hundreds of thousands to a million genetic markers are tested. We treat the approximate Bayes factor as a hybrid Bayes factor which replaces the full data by the maximum likelihood estimates of the parameters of interest in the full model and derive it under a general setting. The deviation from Hardy–Weinberg Equilibrium (HWE) is also taken into account and the ABF for HWE using cases is shown to provide evidence of association between a disease and a genetic marker. Simulation studies and an application are further provided to illustrate the utility of the proposed methodology.     

Approximate Bayes estimation of the parameters and reliability function of a mixture of two inverse Weibull distributions under Type-2 censoring

The main goal of this paper is to develop the approximate Bayes estimation of the five-dimensional vector of the parameters and reliability function of a mixture of two inverse Weibull distributions (MTIWD) under Type-2 censoring. Usually, the posterior distribution is complicated under the scheme of Type-2 censoring and the integrals that are involved cannot be obtained in a simple explicit form. In this study, we use Lindley's [Approximate Bayesian method, Trabajos Estadist. 31 (1980), pp. 223–237] approximate form of Bayes estimation in the case of an MTIWD under Type-2 censoring. Later, we calculate the estimated risks (ERs) of the Bayes estimates and compare them with the corresponding ERs of the maximum-likelihood estimates through Monte Carlo simulation. Finally, we analyse a real data set using the findings.     

Comparison of ANOVA-F and ANOM tests with regard to type I error rate and test power

A Monte Carlo simulation was conducted to compare the type I error rate and test power of the analysis of means (ANOM) test to the one-way analysis of variance F-test (ANOVA-F). Simulation results showed that as long as the homogeneity of the variance assumption was satisfied, regardless of the shape of the distribution, number of group and the combination of observations, both ANOVA-F and ANOM test have displayed similar type I error rates. However, both tests have been negatively affected from the heterogeneity of the variances. This case became more obvious when the variance ratios increased. The test power values of both tests changed with respect to the effect size (Δ), variance ratio and sample size combinations. As long as the variances are homogeneous, ANOVA-F and ANOM test have similar powers except unbalanced cases. Under unbalanced conditions, the ANOVA-F was observed to be powerful than the ANOM-test. On the other hand, an increase in total number of observations caused the power values of ANOVA-F and ANOM test approach to each other. The relations between effect size (Δ) and the variance ratios affected the test power, especially when the sample sizes are not equal. As ANOVA-F has become to be superior in some of the experimental conditions being considered, ANOM is superior in the others. However, generally, when the populations with large mean have larger variances as well, ANOM test has been seen to be superior. On the other hand, when the populations with large mean have small variances, generally, ANOVA-F has observed to be superior. The situation became clearer when the number of the groups is 4 or 5.     

On constructing T 2 control charts for retrospective examination

In this paper we consider the issue of constructing retrospective T ² control chart limits so as to control the overall probability of a false alarm at a specified value. We describe an exact method for constructing the control limits for retrospective examination. We then consider Bonferroni-adjustments to Alt's control limit and to the standard x ² control limit as alternatives to the exact limit since it is computationally cumbersome to find the exact limit. We present the results of some simulation experiments that are carried out to compare the performance of these control limits. The results indicate that the Bonferroni-adjusted Alt's control limit performs better that the Bonferroni-adjusted x ² control limit. Furthermore, it appears that the Bonferroni-adjusted Alt's control limit is more than adequate for controlling the overall false alarm probability at a specified value.     

Evaluation of Linear Mixed Model Case Deletion Diagnostic Tools by Monte Carlo Simulation

A large number of statistics have been proposed to study the influence of individual observations in the linear mixed model. An extensive Monte Carlo simulation study is used to evaluate the appropriateness of these influence diagnostic measures. The sensitivity of the diagnostic measures to outliers and leverages is examined, and helpful results are obtained.     

An Empirical Likelihood Ratio Test for Normality

The empirical likelihood ratio (ELR) test for the problem of testing for normality is derived in this article. The sampling properties of the ELR test and four other commonly used tests are provided and analyzed using the Monte Carlo simulation technique. The power comparisons against a wide range of alternative distributions show that the ELR test is the most powerful of these tests in certain situations.