A sequential design for a clinical trial with a linear prognostic factor

We study a randomized adaptive design to assign one of the L$L$ treatments to patients who arrive sequentially by means of an urn model. At each stage n$n$, a reward is distributed between treatments. The treatment applied is rewarded according to its response, 0?_Yn?1$0?Y_n?1$, and 1-_Yn$1-Y_n$ is distributed among the other treatments according to their performance until stage n-1$n-1$. Patients can be classified in K+1$K+1$ levels and we assume that the effect of this level in the response to the treatments is linear. We study the asymptotic behavior of the design when the ordinary least square estimators are used as a measure of performance until stage n-1$n-1$.     

Considerations on group-wise identical designs for linear mixed models

We consider a general class of mixed models, where the individual parameter vector is composed of a linear function of the population parameter vector plus an individual random effects vector. The linear function can vary for the different individuals. We show that the search for optimal designs for the estimation of the population parameter vector can be restricted to the class of group-wise identical designs, i.e., for each of the groups defined by the different linear functions only one individual elementary design has to be optimized. A way to apply the result to non-linear mixed models is described.     

论广东在明末清初传教活动中的地位

明末清初天主教首先在广东的澳门建立了基地,进而深入肇庆、韶州和广州,然后在北京播种于宫廷、传扬于全国。近代广东得风气之先,在基督教传教活动中起了特殊作用,一因广东具有优越的博采异域文化的地理位置和古老传统;其次由于岭南文化长期以来所形成的内引外联的开放性;再次,明末清初天主教传教士在广东的居留与考察,为其了解中国国情、确立文化传教和结交上层、从而获得合法传教身份的方针提供了人文环境。     

Generalized estimating equations for mixtures with varying concentrations

A finite mixture model is considered in which the mixing probabilities vary from observation to observation. A parametric model is assumed for one mixture component distribution, while the others are nonparametric nuisance parameters. Generalized estimating equations (GEE) are proposed for the semi‐parametric estimation. Asymptotic normality of the GEE estimates is demonstrated and the lower bound for their dispersion (asymptotic covariance) matrix is derived. An adaptive technique is developed to derive estimates with nearly optimal small dispersion. An application to the sociological analysis of voting results is discussed. The Canadian Journal of Statistics 41: 217–236; 2013 © 2013 Statistical Society of Canada     

A Markov regime‐switching model for crude‐oil markets: Comparison of composite likelihood and full likelihood

We use the two‐state Markov regime‐switching model to explain the behaviour of the WTI crude‐oil spot prices from January 1986 to February 2012. We investigated the use of methods based on the composite likelihood and the full likelihood. We found that the composite‐likelihood approach can better capture the general structural changes in world oil prices. The two‐state Markov regime‐switching model based on the composite‐likelihood approach closely depicts the cycles of the two postulated states: fall and rise. These two states persist for on average 8 and 15 months, which matches the observed cycles during the period. According to the fitted model, drops in oil prices are more volatile than rises. We believe that this information can be useful for financial officers working in related areas. The model based on the full‐likelihood approach was less satisfactory. We attribute its failure to the fact that the two‐state Markov regime‐switching model is too rigid and overly simplistic. In comparison, the composite likelihood requires only that the model correctly specifies the joint distribution of two adjacent price changes. Thus, model violations in other areas do not invalidate the results. The Canadian Journal of Statistics 41: 353–367; 2013 © 2013 Statistical Society of Canada     

A Nonstochastic Interpretation of Reported Significance Levels

Tests of significance are often made in situations where the standard assumptions underlying the probability calculations do not hold. As a result, the reported significance levels become difficult to interpret. This article sketches an alternative interpretation of a reported significance level, valid in considerable generality. This level locates the given data set within the spectrum of other data sets derived from the given one by an appropriate class of transformations. If the null hypothesis being tested holds, the derived data sets should be equivalent to the original one. Thus, a small reported significance level indicates an unusual data set. This development parallels that of randomization tests, but there is a crucial technical difference: our approach involves permuting observed residuals; the classical randomization approach involves permuting unobservable, or perhaps nonexistent, stochastic disturbance terms.     

Performance of the One-Sample Goodness-of-Fit P–P-Plot Length Test

This article studies the performance of the one-sample goodness-of-fit test which is based on the length of the P–P-plot initially introduced in a similar context by Reschenhofer and Bomze (1991 Reschenhofer , E. , Bomze , I. M. ( 1991 ). Length tests for goodness-of-fit . Biometrika 78 : 207 – 216 . [Google Scholar]). The distributional properties of the length test are revised empirically via simulations. In the Monte Carlo power study that follows the length test is shown empirically to have high power under various alternatives considered relative to members of the Cramér–von Mises family of goodness-of-fit tests, and the Kolmogorov–Smirnov test.     

Marshall–Olkin Extended Lomax Distribution and Its Application to Censored Data

The problem of making statistical inference about θ =P(X > Y) has been under great investigation in the literature using simple random sampling (SRS) data. This problem arises naturally in the area of reliability for a system with strength X and stress Y. In this study, we will consider making statistical inference about θ using ranked set sampling (RSS) data. Several estimators are proposed to estimate θ using RSS. The properties of these estimators are investigated and compared with known estimators based on simple random sample (SRS) data. The proposed estimators based on RSS dominate those based on SRS. A motivated example using real data set is given to illustrate the computation of the newly suggested estimators.     

Subset selection based on likelihood from uniform and related popupulations

Let π_i (i=1,2,…, k) be charceterized by the uniform distribution on (a_i;b_i), where exactly one of a_i and b_i is unknown. With unequal sample sizes, suppose that from the k (>=2) given populations, we wish to select a random-size subset containing the one with the smllest value of θ_i= b_i - a_i. RuleR_i selects π if a likelihood-based k-dimensional confidence region for the unknown (θ₁,… θ_k) contains at least one point having θ_i as its smallest component. A second rule, R , is derived through a likelihood ratio and turns out to be that of Barr and prabhu whenthe sample sizes are equal. Numerical comparisons are made. The results apply to the larger class of densities g ( z ; θ_i) =M(z)Q(θ_i) if a(θ_i) < z <b(θ_i). Extensions to the cases when both a_i and b_i are unknown and when θ_j isof interest are indicated. 1<=j<=k     

Estimation in capture–recapture models when covariates are subject to measurement errors and missing data

For capture–recapture models when covariates are subject to measurement errors and missing data, a set of estimating equations is constructed to estimate population size and relevant parameters. These estimating equations can be solved by an algorithm similar to the EM algorithm. The proposed method is also applicable to the situation when covariates with no measurement errors have missing data. Simulation studies are used to assess the performance of the proposed estimator. The estimator is also applied to a capture–recapture experiment on the bird species Prinia flaviventris in Hong Kong. The Canadian Journal of Statistics 37: 645–658; 2009 © 2009 Statistical Society of Canada