Healthy Barbs: Activism Confronts Mortality

Barbara Brenner, JD, was the Executive Director of Breast Cancer Action (BCA) from 1995–2010. Before that, she was a longtime activist in the anti-war movement and an attorney who, for most of her career, practiced public policy law. After she was diagnosed with breast cancer in 1993 at the age of 41, she took the helm of BCA. Under her leadership, the organization moved into a position of national advocacy—demanding research on the causes and prevention of breast cancer, including the role of industrial pollutants. Barbara started the “Think Before You Pink” campaign, encouraging people to question whether companies that display pink ribbons actually produce products that harm women's health or generate any funds to fight breast cancer. Her blog, “Healthy Barbs,” challenged readers to critique routine healthcare practices and policies. Barbara received numerous awards, including a Jefferson Award for Public Service in 2007, the Smith College Medal in 2012, and the ACLU-Northern California's Lola Hanzel Courageous Advocacy Award in 2012. Barbara had a recurrence of breast cancer in 1996. She died of complications associated with amyotrophic lateral sclerosis, ALS, on May 10, 2013.     

The Relationship Between Child Sexual Abuse and Alexithymic Symptoms in a Population of Recovering Adult Substance Abusers

ABSTRACT

Recovering substance abusers with a history of childhood sexual abuse (n = 69) or no history of childhood sexual abuse (n = 68) completed the Toronto Alexithymia Scale (TAS) and a background survey assessing demographic data and (In the case of sexually abused respondents) parameters of the childhood abuse experienced. The sexually abused group scored significantly higher than the non-abused group on the TAS. Within the abused group, measured alexithymic symptomatology was found to be related positively to the duration of the abuse. Alexithymia was significantly higher when the sexual abuse first occurred after the victim had reached the age of 12, when a perpetrator of the sexual abuse was a father or stepfather, and when the abuse involved oral, vaginal, and/or anal penetration. Results were interpreted as indicating that the development of alexithymic symptoms may represent another defense victims may employ to insulate themselves from painful affect, along with dissociative symptoms and substance abuse, which have been shown previously to characterize adult survivors of child sexual abuse.     

中国上市公司财务预警实证研究

在对国外公司财务预警经典研究成果进行回顾和总结的基础上,运用多元判别分析方法（MDA）和逐步判别分析（Stepdisc）等方法逐层推进构造预测模型,以经济实用为选择标准,最终建立一个预测准确率最高、变量最少的适合中国实际情况的财务危机预测模型。     

Testing for lack of fit in linear multiresponse models based on exact or near replicates

Three procedures for testing the adequacy of a proposed linear multiresponse regression model against unspecified general alternatives are considered. The model has an error structure with a matrix normal distribution which allows the vector of responses for a particular run to have an unknown covariance matrix while the responses for different runs are uncorrelated. Furthermore, each response variable may be modeled by a separate design matrix. Multivariate statistics corresponding to the classical univariate lack of fit and pure error sums of squares are defined and used to determine the multivariate lack of fit tests. A simulation study was performed to compare the power functions of the test procedures in the case of replication. Generalizations of the tests for the case in which there are no independent replicates on all responses are also presented.     

Extension of two-sided test to multiple treatment trials

In a two-treatment trial, a two-sided test is often used to reach a conclusion, Usually we are interested in doing a two-sided test because of no prior preference between the two treatments and we want a three-decision framework. When a standard control is just as good as the new experimental treatment (which has the same toxicity and cost), then we will accept both treatments. Only when the standard control is clearly worse or better than the new experimental treatment, then we choose only one treatment. In this paper, we extend the concept of a two-sided test to the multiple treatment trial where three or more treatments are involved. The procedure turns out to be a subset selection procedure; however, the theoretical framework and performance requirement are different from the existing subset selection procedures. Two procedures (exclusion or inclusion) are developed here for the case of normal data with equal known variance. If the sample size is large, they can be applied with unknown variance and with the binomial data or survival data with random censoring.     

基于高维分步投影的多重分区聚类算法

数据分布密度划分的聚类算法是数据挖掘聚类算法的主要方法之一。针对传统密度划分聚类算法存在运算复杂、运行效率不高等缺陷,设计高维分步投影的多重分区聚类算法;以高维分布投影密度为依据,对数据集进行多重分区,产生数据集的子簇空间,并进行子簇合并,形成理想的聚类结果;依据该算法进行实验,结果证明该算法具有运算简单和运行效率高等优良性。     

众数测算的一种新方法及其应用

针对传统众数估计值会因为组距的改变而不稳定,在已有的半极差(样本)众数估计方法上,提出多比例极差(样本)众数估计新方法。模拟研究显示,相对于半极差(样本)众数估计方法,该方法估计结果更稳定、准确。在实证分析中,基于2014、2015年国家一体化住户调查数据,使用新方法计算了新疆兵团居民人均可支配收入众数。结果表明,众数可以作为居民人均可支配收入平均数、中位数的有益补充,众数在政府统计中的推广及应用具有一定的可行性与必要性。     

Using multiple imputation to estimate cumulative distribution functions in longitudinal data analysis with data missing at random

In longitudinal clinical studies, after randomization at baseline, subjects are followed for a period of time for development of symptoms. The interested inference could be the mean change from baseline to a particular visit in some lab values, the proportion of responders to some threshold category at a particular visit post baseline, or the time to some important event. However, in some applications, the interest may be in estimating the cumulative distribution function (CDF) at a fixed time point post baseline. When the data are fully observed, the CDF can be estimated by the empirical CDF. When patients discontinue prematurely during the course of the study, the empirical CDF cannot be directly used. In this paper, we use multiple imputation as a way to estimate the CDF in longitudinal studies when data are missing at random. The validity of the method is assessed on the basis of the bias and the Kolmogorov–Smirnov distance. The results suggest that multiple imputation yields less bias and less variability than the often used last observation carried forward method. Copyright © 2013 John Wiley & Sons, Ltd.     

A multivariate solution of the multivariate ranking and selection problem

The problem of selection of the best multivariate population is given a new formulation which does not involve reducing the populations to univariate quantities. This formulation's solution is developed for known, and (using the Heteroscedastic Method) also for unknown, variance-covariance matrices. Preference reversals and arbitrary nonlinear preference functions are explicitly allowed in this new theory     

On Calculations Involving the Maximum Cell Frequency

We describe a method of computing the cumulative distribution function of the maximum and minimum cell frequencies in sampling distributions commonly encountered in the analysis of categorical data.The procedure is efficient for exact or approximate calculation in both homogeneous and non-homogeneous cases, is non-recursive, and does not require Dirichlet integrals.Some related statistical problems are also discussed.