Estimation of Metabolic Rate Constants in PBPK‐Models from Liver Slice Experiments: What Are the Experimental Needs?

A mechanistic model is presented describing the clearance of a compound in a precision-cut liver slice that is incubated in a culture medium. The problem of estimating metabolic rate constants in PBPK models from liver slice experiments is discussed using identifiability analysis. From the identifiability problem analysis, it appears that in addition to the clearance, the compound's free fraction in the slice and the diffusion rate of the exchange of the compound between culture medium and liver slice should be identified. In addition, knowledge of the culture medium volume, the slice volume, the compound's free fraction, and octanol-water-based partition between medium and slice is presupposed. The formal solution for identification is discussed from the perspective of experimental practice. A formally necessary condition for identification is the sampling of parent compound in liver slice or culture medium. However, due to experimental limitations and errors, sampling the parent compound in the slice together with additional sampling of metabolite pooled from the medium and the slice is required for identification in practice. Moreover, it appears that identification results are unreliable when the value of the intrinsic clearance exceeds the value of the diffusion coefficient, a condition to be verified a posteriori.     

从国际法看巴勒斯坦建国

巴勒斯坦建国问题是巴以冲突中悬而未决的棘手问题，在当前巴以和平进程受挫情况下，它渐渐成为巴以和谈的重要议题，且有可能成为和谈的突破口．本文从国际法角度，结合历史，分析了巴建国问题在法理上具备了哪些条件，缺哪些条件，据此对巴建国前景作个预测．     

再论《国殇》与《九歌》

《九歌》是屈原在民间“九歌”基础上写定的 ,可以认为是屈原所作或创造的。《国殇》是为牺牲的楚国将士而举行驱鬼活动的主祭歌。《国殇》以外的《九歌》其他篇 ,主要是表现对九位天神地的恭敬、赞美和依恋 ,《九歌》中的神、巫、人、鬼关系 ,就是一个由人和巫迎请神、送行鬼魂的过程     

How to do or not do things with words: The case of Koreans in Japan

In this article, I explore the ways in which ethnic identity is expressed by following the formulaic socio-linguistic norm, the very method of which defies the authenticity of identity itself, thereby asserting the identity's multi-facetedness as sustained in performative linguistic practice. I look at multi-sited socio-linguistic interactions among Koreans in Japan, who claim their primary identity to be that of North Korea's overseas citizens even though none of them have North Korean passport or nationality. Their identity, in other words, is based on ideological commitment, which is in reality supported by their ongoing linguistic practice. A close look at their socio-linguistic life reveals their ethnicity's dual or multiple ontology, which challenges among other things the currently dominant assertion of Japanese self in the western academic discourse.     

Determinants of female labor force participation: A study of Seoul,South Korea, 1970–1980

This paper investigates the determinants of labor force participation of women living in male-headed households in Seoul, South Korea, at two points in time, 1970 and 1980. Analysis of data from the 1970 and 1980 Korean Population Censuses suggests that both women's educational level and the family economic status determine women's labor force participation in Seoul. Women with middle school education or above are more economically active than those with no education. Women from lower economic backgrounds are almost two to three times more likely to be employed than those in high-status families, controlling for age, number of children under 6, and marital status. However, this pattern is not found among women from the blue-collar wage-working families.An earlier version of this paper was presented at the 1988 meetings of the Population Association of America.     

Threshold decisions: how social workers prioritize referrals of child concern

This paper examines local authority social workers' decision‐making when considering referrals of children, where the concerns are on the margin of child protection procedures. In doing so, it describes the findings of a qualitative research study undertaken in the policy context of attempts to ‘refocus’ social work practice in the late 1990s and early twenty‐first century. Data collection involved interviews with social workers and parents in 23 cases. Conclusions are that referrals were evaluated on the basis of five key factors, specificity, severity, risk, parental accountability and corroboration, the use of which determined whether an initial assessment or an investigation of alleged abuse took place. The analysis builds on previous work in the child protection field, but demonstrates how the application of these factors differs between cases of child concern and cases of child protection. Policy implications concern the complexity of decision‐making in the uncertain context of limited referral information and it is proposed that the simplistic notion of a continuum of abuse is now outdated. Copyright © 2006 John Wiley & Sons, Ltd.     

社会边缘群体对社会稳定的影响及对策--以哈尔滨建筑业农民工为例

社会稳定和社会边缘群体的生存状况紧密相连.建筑业农民工群体是中国社会边缘群体的重要组成部分,必须通过实证研究分析他们的生存状态及其与社会稳定之间的关系.通过抽样方法和问卷调查,从经济状况、社会分配、社会心理和社会控制等四个方面透视哈尔滨市建筑业农民工群体的生活状况,目前还不是影响社会稳定的因素.但从长期来看,若不注重研究并改善其境遇,则可能成为社会稳定的隐患.鉴于此,必须综合利用农民工社会保障制度、工会组织、技能培训、改善食宿和安全条件以及多样化的休闲途径,来保证这一群体的生活质量和合法权益,以维护社会稳定.     

Race and Population Change: A Longitudinal Look at Cleveland Neighborhoods

This paper investigates the relationship of racial composition to neighborhood population change from 1910 to 1990 in the Cleveland metropolitan area. To better understand the long-term dynamics of urban neighborhood change, we focus our analysis upon the longitudinal relationship of race, socioeconomic status, and life cycle stage to changes in neighborhood population densities. First, we find that the more established neighborhoods of the African-American community have experienced dramatic declines in population since 1950, a pattern that represents a clear change from the earlier part of the twentieth century. Second, population loss is experienced through a variety of mechanisms, including the demolition of dwellings, the increase in housing vacancy, and the decline of household size. Third, much of this population loss should be interpreted within the context of high economic distress, occurring most frequently in older African-American communities. Over time, economic distress appears to be more important than race in and of itself in leading to the loss of neighborhood populations.     

Television and Violence in the Economy of Memory

The present paper aims to consider the cultural function of television as a technology for the creation of a public memory. The television system records past images, preserves them, and broadcasts various historical programs. A viewer owns the public memory jointly, through watching/consuming programs. However, the process of production and consumption of programs is linked with the exclusion of other historical memories from the public space. After all, the creation of public memories in depth is related to social power. Through the analysis in concrete terms of a series of programs of Project X and the second episode of the Nippon Hoso Kyokai (NHK; Japan Broadcasting Corporation) series, Special Edition: Judging War, the relationship between the organization of public memories and social power is explored. Project X depicts the challenges of engineers of middle standing who initiated new industrial and technological developments in the 1960s and 1970s. Special Edition: Judging War is based on coverage of the Women's International War Crimes Tribunal on Japan's Military Sexual Slavery. This program was subjected to revision on the eve of its broadcast. What forms of expression were eliminated? These two programs should help us define more clearly what the Japanese media selects for incorporation into the public memory.