Alterations in IGF-I affect elderly: role of physical activity

The growth hormone–insulin-like growth factor I (IGF-I) axis is an important physiological regulator muscle for development. Although there is evidence that aging muscle retains the ability to synthesize IGF-I, there is also evidence that aging may be associated with attenuation of the ability of exercise to induce an isoform of IGF-I that promotes satellite cell proliferation. However, it is clear that overexpression of IGF-I in the muscle can protect against age-related sarcopenia. Strength training appears to be the intervention of choice for the prevention and treatment of sarcopenia. IGF-I has been implicated in the loss of the muscle with age, and IGF-I expression levels change as a consequence of strength training in older adults. However, it seems that advancing age, rather than declining serum levels of IGF-I, appears to be a major determinant of life-time changes in body composition in women and men. We concluded that resistive exercise is a significant determinant of muscle mass and function. Elevated levels of IGF-I have been found in physically active compared to sedentary individuals. Recent work suggests that IGF-I as a mediator plays an important role in muscle hypertrophy and angiogenesis, both of which characterize the anabolic adaptation of muscles to exercise.     

从"分数"选拔机制向"配套程序"选拔机制转换的司法人才培养制度——日本新司法考试制度及其启示

日本新司法考试制度是从过去靠"分数"选拔机制向通过"配套程序"选拔新的司法人才培养制度转换的一种新举措。它以法科大学院受到充实的教育以及严格的成绩评价和毕业认定为前提、以法科大学院的教育内容为基础而实施考试。它旨在通过司法考试和经过司法培训,确保法科大学院毕业生拥有法律道德素质以及思考力、分析力、辩论等能力。     

A Stochastic Assessment of the Public Health Risks of the Use of Macrolide Antibiotics in Food Animals

Campylobacteriosis is an important food-borne illness with more than a million U.S. cases annually. Antibiotic treatment is usually not required. However, erythromycin, a macrolide antibiotic, is recommended for the treatment of severe cases. Therefore, it is considered a critically important antibiotic and given special attention as to the risk that food animal use will lead to resistant infections and compromised human treatment. To assess this risk, we used a retrospective approach; estimating the number of campylobacteriosis cases caused by specific meat consumption utilizing the preventable fraction. We then determined the number of cases with macrolide resistance Campylobacter spp. based on a linear model relating the resistance fraction to on-farm macrolide use. In this article, we considered the uncertainties in the parameter estimates, utilized a more elaborate model of resistance development and separated C. coli and C. jejuni . There are no published data for the probability of compromised treatment outcome due to macrolide resistance. Therefore, our estimates of compromised treatment outcome were based on data for fluoroquinolone-resistant infections. The conservative results show the human health risks are extremely low. For example, the predicted risk of suboptimal human treatment of infection with C. coli from swine is only 1 in 82 million; with a 95% chance it could be as high as 1 in 49 million. Risks from C. jejuni in poultry or beef are even less. Reduced antibiotic use can adversely impact animal health. These low human risks should be weighed against the alternative risks.     

普通台面工艺制作新型超薄基区负阻HBT

负阻型HBT既保持了原HBT高频、高速的特点,同时又具有负阻、双稳、自锁等特性,是一种极具研究价值的新型负阻器件。该文从Early效应造成超薄基区穿通,器件由双极工作状态向体势垒管工作状态转变从而形成负阻特性的思路出发,通过对材料结构的特殊设计,采用普通台面工艺研制出了基区厚度为8nm的负阻型HBT。该器件具有独特且显著的可变电压控制型负阻特性,其电流峰谷比大于1000,并伴有电流控制型负阻。     

关于贵州农村精神文明建设问题的思考

在社会主义发展的今天，贵州省农村的建设，在大力发展物质文明的同时，更应注意精神文明建设问题。本文从认识农村精神文明建设的意义等方面着手，剖析了精神文明建设对贵州农村地区建设和发展的推动作用，对于提高贵州农民的整体素质，建立行之有效的农民职业技术培训体系提出了意见和建议，同时也阐明了共产党员在贵州农村精神文明建设中所发挥的特殊作用。     

大学生科技创新素质培养的评价指标体系构建与研究

经过理论分析、专家打分、指标优化及参数修正等过程确立了包括创新意识、知识水平、创新环境、创新素质、标志成果等具体指标的评价体系，以及各指标下属项目、相应权重和计算方法，对大学生科技创新活动高效可持续开展提供具体的理论依据并给予指导。     

物理学史与大学物理素质教育

物理学史在大学物理素质教育中不但可以培养学生的科学素质和创造素质，还能培养学生的非智力因素。物理教师授课时结合相关素材，选择适当的教学手段和方法，将使物理学史在大学物理素质教育中起到积极作用。     

河北理工大学工程硕士培养

针对工程硕士培养的特点,结合河北理工大学4年来的硕士培养管理工作中的实践经验。从制定切实可行的培养方案,选聘高质量的任课教师,灵活安排学习时间,狠抓学位论文工作等方面介绍了工程硕士培养质量保证措施。     

知识经济背景下地方工科院校多样化人才培养模式研究

地方工科院校是我国高等教育体系中一个相对独立的层面，其人才培养模式的改革研究与实践对我国经济腾飞和中华复兴亦将产生重要推动作用。面对当前知识经济浪潮的来临，提出多样化是当前地方工科院校人才培养模式改革的新思路。