Description and evaluation of a nested cube experimental design

An incomplete factorial design based on an extension of the Fawiliar 2^kfactorial called a nested cube is proposed for use in response surface investigationso The simplicity and general efficiency of the nested cube suggest its suitability to many areas of research, especially that repeated at many locations orconductea over a long period. Comparisons to potentially competing designs are provided for bias in response estination due to fitting an ioappropriate model and for profiles of variance. merits of the nested cube are (1) a level of relative bias and variance judged to be favorable though not optimal, (2) an ability to utilize a minimum blag estimator not available to competing designs, and (3) a simplicity associated with use of equal spacing

and nearly equal replication on the margin for each factor level.     

Improved pretest nonparametric estimation in a multivariate regression model

Shrinkage pretest nonparametric estimation of the location parameter vector in a multivariate regression model is considered when nonsample information (NSI) about the regression parameters is available. By using the quadratic risk criterion, the dominance of the pretest estimators over the usual estimators has been investigated. We demonstrate analytically and computationally that the proposed improved pretest estimator establishes a wider dominance range for the parameter under consideration than that of the usual pretest estimator in which it is superior over the unrestricted estimator.     

Estimating the minimum and maximum location parameters for two ig-exponential scale mixtures

Suppose that we have two components, each having a two-parameter exponential distribution. Suppose further that these components are conditionally independent, sharing a common random hazard rate and possessing unequal, fixed, unknown location parameters. We develop estimators for the minimum and maximum of these location parameters when the random hazard rate has an inverse Gaussian distribution. Performance comparisons are made among the proposed estimators. Maximum likelihood estimators are shown to be inadmissible.     

Timing the Use of Breast Cancer Risk Information in Biopsy Decision‐Making

Available clinical evidence is inconclusive on whether radiologists should use the patient risk profile information when interpreting mammograms. On the one hand, risk profile information is informative and can improve radiologists’ performance, but on the other hand, it may impair their judgment by introducing biases in mammography interpretation. Therefore, it is important to assess whether and when profile information use translates into improved outcomes. We model the use of profile information in mammography, using a decision theoretic approach and explore the value of profile information using three process design choices: mammography only, unbiased, and biased reading. We estimate the parameters of our model using clinical data and find that using profile information along with the mammography information can achieve a better performance than not using the profile information. However, the better performance is contingent on the weight assigned to the profile information as well as the extent of bias due to profile information. Translating our findings into clinical practice would require properly designed experiments aiming to quantify the effect of the timing and the use of profile information on performance while accounting for radiologist and patient characteristics. When conducting an experiment is not feasible, a uniform operational sequence for interpreting mammograms and related guidelines may be a useful starting point to improve the quality of mammography operations.     

A balanced multi-level rotation sampling design and its efficient composite estimators

We present a multi-level rotation sampling design which includes most of the existing rotation designs as special cases. When an estimator is defined under this sampling design, its variance and bias remain the same over survey months, but it is not so under other existing rotation designs. Using the properties of this multi-level rotation design, we derive the mean squared error (MSE) of the generalized composite estimator (GCE), incorporating the two types of correlations arising from rotating sample units. We show that the MSEs of other existing composite estimators currently used can be expressed as special cases of the GCE. Furthermore, since the coefficients of the GCE are unknown and difficult to determine, we present the minimum risk window estimator (MRWE) as an alternative estimator. This MRWE has the smallest MSE under this rotation design and yet, it is easy to calculate. The MRWE is unbiased for monthly and yearly changes and preserves the internal consistency in total. Our numerical study shows that the MRWE is as efficient as GCE and more efficient than the existing composite estimators and does not suffer from the drift problem [Fuller W.A., Rao J.N.K., 2001. A regression composite estimator with application to the Canadian Labour Force Survey. Surv. Methodol. 27 (2001) 45–51] unlike the regression composite estimators.     

Bias reduction of maximum likelihood estimates for a modified skew-normal distribution

ABSTRACT

This paper presents a modified skew-normal (SN) model that contains the normal model as a special case. Unlike the usual SN model, the Fisher information matrix of the proposed model is always non-singular. Despite of this desirable property for the regular asymptotic inference, as with the SN model, in the considered model the divergence of the maximum likelihood estimator (MLE) of the skewness parameter may occur with positive probability in samples with moderate sizes. As a solution to this problem, a modified score function is used for the estimation of the skewness parameter. It is proved that the modified MLE is always finite. The quasi-likelihood approach is considered to build confidence intervals. When the model includes location and scale parameters, the proposed method is combined with the unmodified maximum likelihood estimates of these parameters.     

On Comparing Apples with Apples Deemed Nonexistent: A Reply to Johnson

ABSTRACT

M. Johnson's rebuttal is an example of the paradigm I described to readers in my original article. Johnson develops a taxonomy of intimate violence where female initiated violence does not exist. He does this despite extensive evidence to the contrary. A recent national survey included questions about both severity and instrumentality of violence given to both genders. Intimate terrorism (as defined by a combination of instrumentality and repletion of severe violence) is perpetrated by both genders (2.6% of women and 4.2% of men). The notion that women do not initiate domestic violence is misleading to custody assessors who must consider risk to children as part of the child's best interest.     

A comparison of the estimative and predictive methods of estimating posterior probabilities

An asymptotic account Is presented on the relative performance of the so-called estimative and predictive methods of estimating the posterior probability that an object belongs to one of two possible multivariate normal populations. For equal prior probabil-ities it is concluded that the predictive method generally gives a less extreme estimate than the estimative. This is supported by previously available results based essentially on simulation studies. Conditions under which the predictive method provides less extreme estimates for arbitrary prior probabilities are considered. Also, the asymptotic biases associated with the two methods are compared.     

Interchangeability of the ratio and product methods in sample surveys

The paper demonstrates the interchangeability of the ratio and product methods of estimation i n sample surveys through translati n g the unbiased estimator of the population total of the auxiiart variate (or the study varia te). The values of the translation parameters minimizing the mean squared error are obtained. The allowable departures from this optimum, which still ensure a reduction in the mean squared error, as compared to the traditional case, are indicated.     

Correcting for regression dilution bias: comparison of methods for a single predictor variable

In an epidemiological study the regression slope between a response and predictor variable is underestimated when the predictor variable is measured imprecisely. Repeat measurements of the predictor in individuals in a subset of the study or in a separate study can be used to estimate a multiplicative factor to correct for this 'regression dilution bias'. In applied statistics publications various methods have been used to estimate this correction factor. Here we compare six different estimation methods and explain how they fall into two categories, namely regression and correlation-based methods. We provide new asymptotic variance formulae for the optimal correction factors in each category, when these are estimated from the repeat measurements subset alone, and show analytically and by simulation that the correlation method of choice gives uniformly lower variance. The simulations also show that, when the correction factor is not much greater than 1, this correlation method gives a correction factor which is closer to the true value than that from the best regression method on up to 80% of occasions. We also provide a variance formula for a modified correlation method which uses the standard deviation of the predictor variable in the main study; this shows further improved performance provided that the correction factor is not too extreme. A confidence interval for a corrected regression slope in an epidemiological study should reflect the imprecision of both the uncorrected slope and the estimated correction factor. We provide formulae for this and show that, particularly when the correction factor is large and the size of the subset of repeat measures is small, the effect of allowing for imprecision in the estimated correction factor can be substantial.