Estimation of Metabolic Rate Constants in PBPK‐Models from Liver Slice Experiments: What Are the Experimental Needs?

A mechanistic model is presented describing the clearance of a compound in a precision-cut liver slice that is incubated in a culture medium. The problem of estimating metabolic rate constants in PBPK models from liver slice experiments is discussed using identifiability analysis. From the identifiability problem analysis, it appears that in addition to the clearance, the compound's free fraction in the slice and the diffusion rate of the exchange of the compound between culture medium and liver slice should be identified. In addition, knowledge of the culture medium volume, the slice volume, the compound's free fraction, and octanol-water-based partition between medium and slice is presupposed. The formal solution for identification is discussed from the perspective of experimental practice. A formally necessary condition for identification is the sampling of parent compound in liver slice or culture medium. However, due to experimental limitations and errors, sampling the parent compound in the slice together with additional sampling of metabolite pooled from the medium and the slice is required for identification in practice. Moreover, it appears that identification results are unreliable when the value of the intrinsic clearance exceeds the value of the diffusion coefficient, a condition to be verified a posteriori.     

再论《国殇》与《九歌》

《九歌》是屈原在民间“九歌”基础上写定的 ,可以认为是屈原所作或创造的。《国殇》是为牺牲的楚国将士而举行驱鬼活动的主祭歌。《国殇》以外的《九歌》其他篇 ,主要是表现对九位天神地的恭敬、赞美和依恋 ,《九歌》中的神、巫、人、鬼关系 ,就是一个由人和巫迎请神、送行鬼魂的过程     

以德治国"与大学生道德教育

以德治国方略的提出 ,把德治与法治结合起来形成一个完整的治国方略 ,是我党治国方略上的新进展。“以德治国”具体到高校来说 ,就是以德治校 ,以德修己 ,以德育人。因此 ,这对大学生道德教育提出了新的要求。我们要正确认识理解德治、法治、人治等相互关系 ,以“两课”教育为主渠道 ,加强和改进大学生道德教育。     

How to do or not do things with words: The case of Koreans in Japan

In this article, I explore the ways in which ethnic identity is expressed by following the formulaic socio-linguistic norm, the very method of which defies the authenticity of identity itself, thereby asserting the identity's multi-facetedness as sustained in performative linguistic practice. I look at multi-sited socio-linguistic interactions among Koreans in Japan, who claim their primary identity to be that of North Korea's overseas citizens even though none of them have North Korean passport or nationality. Their identity, in other words, is based on ideological commitment, which is in reality supported by their ongoing linguistic practice. A close look at their socio-linguistic life reveals their ethnicity's dual or multiple ontology, which challenges among other things the currently dominant assertion of Japanese self in the western academic discourse.     

Threshold decisions: how social workers prioritize referrals of child concern

This paper examines local authority social workers' decision‐making when considering referrals of children, where the concerns are on the margin of child protection procedures. In doing so, it describes the findings of a qualitative research study undertaken in the policy context of attempts to ‘refocus’ social work practice in the late 1990s and early twenty‐first century. Data collection involved interviews with social workers and parents in 23 cases. Conclusions are that referrals were evaluated on the basis of five key factors, specificity, severity, risk, parental accountability and corroboration, the use of which determined whether an initial assessment or an investigation of alleged abuse took place. The analysis builds on previous work in the child protection field, but demonstrates how the application of these factors differs between cases of child concern and cases of child protection. Policy implications concern the complexity of decision‐making in the uncertain context of limited referral information and it is proposed that the simplistic notion of a continuum of abuse is now outdated. Copyright © 2006 John Wiley & Sons, Ltd.     

社会边缘群体对社会稳定的影响及对策--以哈尔滨建筑业农民工为例

社会稳定和社会边缘群体的生存状况紧密相连.建筑业农民工群体是中国社会边缘群体的重要组成部分,必须通过实证研究分析他们的生存状态及其与社会稳定之间的关系.通过抽样方法和问卷调查,从经济状况、社会分配、社会心理和社会控制等四个方面透视哈尔滨市建筑业农民工群体的生活状况,目前还不是影响社会稳定的因素.但从长期来看,若不注重研究并改善其境遇,则可能成为社会稳定的隐患.鉴于此,必须综合利用农民工社会保障制度、工会组织、技能培训、改善食宿和安全条件以及多样化的休闲途径,来保证这一群体的生活质量和合法权益,以维护社会稳定.     

Television and Violence in the Economy of Memory

The present paper aims to consider the cultural function of television as a technology for the creation of a public memory. The television system records past images, preserves them, and broadcasts various historical programs. A viewer owns the public memory jointly, through watching/consuming programs. However, the process of production and consumption of programs is linked with the exclusion of other historical memories from the public space. After all, the creation of public memories in depth is related to social power. Through the analysis in concrete terms of a series of programs of Project X and the second episode of the Nippon Hoso Kyokai (NHK; Japan Broadcasting Corporation) series, Special Edition: Judging War, the relationship between the organization of public memories and social power is explored. Project X depicts the challenges of engineers of middle standing who initiated new industrial and technological developments in the 1960s and 1970s. Special Edition: Judging War is based on coverage of the Women's International War Crimes Tribunal on Japan's Military Sexual Slavery. This program was subjected to revision on the eve of its broadcast. What forms of expression were eliminated? These two programs should help us define more clearly what the Japanese media selects for incorporation into the public memory.     

我国区域刑事法律冲突初探

我国各民族之间的差异、民族区域自治制度及其自治权的存在是我国区域刑事法律冲突产生的基本原因,而通过制定顾全大局、兼顾特别的变通性、补充性刑法规范,可缓解这一冲突;通过加快少数民族地区的发展步伐,逐步消除民族之间的政治、经济、文化上的差距,进而达到彻底消除这一冲突,实现法制统一的良好局面。     

论"入世"后的职务犯罪及其防治

我国“入世” ,经济运行环境和行政管理模式将发生变化。关税减让、政务公开 ,减少了职务犯罪的机会 ;贸易自由、审批权集中 ,增大了职务犯罪的可能性。减少由“入世”给防治职务犯罪带来的消极影响 ,其根本措施仍是继续坚持“教育是基础 ,法制是保障 ,监督是关键”的方针 ,打防结合 ,标本兼治