Test for homogeneity in Hardy–Weinberg normal mixture model

The phenotype of a quantitative trait locus (QTL) is often modeled by a finite mixture of normal distributions. If the QTL effect depends on the number of copies of a specific allele one carries, then the mixture model has three components. In this case, the mixing proportions have a binomial structure according to the Hardy–Weinberg equilibrium. In the search for QTL, a significance test of homogeneity against the Hardy–Weinberg normal mixture model alternative is an important first step. The LOD score method, a likelihood ratio test used in genetics, is a favored choice. However, there is not yet a general theory for the limiting distribution of the likelihood ratio statistic in the presence of unknown variance. This paper derives the limiting distribution of the likelihood ratio statistic, which can be described by the supremum of a quadratic form of a Gaussian process. Further, the result implies that the distribution of the modified likelihood ratio statistic is well approximated by a chi-squared distribution. Simulation results show that the approximation has satisfactory precision for the cases considered. We also give a real-data example.     

大中专在校学生考试分数的正态化线性转换

本文分析了考试记分方法中传统的绝对百分体制的缺陷，给出了一种正态化转换分数的算法，较适合于在校大中专学生学习水平的横向评价。     

Generalized partially linear varying-coefficient models

Generalized varying-coefficient models are useful extensions of generalized linear models. They arise naturally when investigating how regression coefficients change over different groups characterized by certain covariates such as age. In this paper, we extend these models to generalized partially linear varying-coefficient models, in which some coefficients are constants and the others are functions of certain covariates. Procedures for estimating the linear and non-parametric parts are developed and their associated statistical properties are studied. The methods proposed are illustrated using some simulations and real data analysis.     

Model diagnostics for smoothing spline ANOVA models

The author proposes some simple diagnostics for assessing the necessity of selected terms in smoothing spline ANOVA models. The elimination of practically insignificant terms generally enhances the interpretability of the estimates and sometimes may also have inferential implications. The diagnostics are derived from Kullback‐Leibler geometry and are illustrated in the settings of regression, probability density estimation, and hazard rate estimation.     

L~1空间上的Fourier乘子判定定理

本文利用Torchinsky分解和一种全新的二进制分解得到一个极为有用的L1空间上的Fourier乘子的判定定理.该定理较之经典的判定定理适用于更为广泛的一类乘子.     

社会主义初级阶段人的不全面性及其克服

由于社会主义初级阶段还不是那种已为人的全面发展提供了现实的社会生产力和高度文明的基础的社会阶段,还处于“以物的依赖性为基础的人的独立性”的历史阶段,人的发展仍然具有不全面性。大力发展生产力,努力营造良好的社会环境,发展文化教育,加强道德建设,是克服和消除人的发展不全面性的有效途径。     

西北少数民族地区乡村初级群体及其功能分析

社会群体是人们社会生活中的具体单位,社会群体生活是人们的基本生活方式,因此,群体就成为社会学研究的主要组成部分,社会学如此,民族社会学更如此。处于转型期的西北民族乡村社会,社会群体特别是初级群体依然扮演着极其重要的角色。对其进行功能分析有助于深化对它们的认识。     

基于二阶段随机规划的城市医疗废弃物回收网络设计

城市医疗废弃物日益增加,且回收需求量受诸多因素的影响,难以准确预测,假定回收需求为确定值的医疗废弃物网络优化设计不能与实际需求相匹配。本文考虑了离散随机参数环境下,医疗回收网络设计中选址规划、分配计划及运输规划的协同优化问题,建立了以选址成本、运输成本最小为目标,设施与车辆能力限制为约束的二阶段随机规划模型。根据模型特点,设计了基于Benders decomposition的求解算法,同时,设计了一系列加速技术用于提高算法的求解效率。最后,以国内某城市医疗回收网络为背景设计算例,检验本文模型和求解策略的可行性和有效性。结果表明：相比确定性规划,随机规划的解能够节约总成本,结合一系列加速技术的Benders decomposition方法比CPLEX与纯的Benders decomposition更有优势。     

基层治理中党建引领力的构成及其提升路径——从基层组织能力视角分析

基层治理中的基层组织能力是其“三阶”能力或“两层”能力的集合。从基层组织能力视角来看,基层治理能力来源于基层组织能力,由各基层组织治理能力整合而成。各基层组织在治理中职责与能力的差异形成了基层治理能力的同心圆结构。其中,基层党组织以党建引领基层治理的方式履行职责。党建引领基层治理能力即基层党建引领力,是基层治理能力的核心,是基层治理中制度优势更好转化为治理效能的关键。基于新时代党建六方面要求,基层党建引领力包含六个维度的引领,其功能各异,但相辅相成。为化解当前党建引领基层治理面临的问题,各地基层党组织可根据基层党建引领力评估指标的设计指南,因地制宜制定具体评估指标体系,重点推进、协同推进、整体推进,提升基层党建引领力,从而促进基层治理能力的提高,将制度优势更好地转化成基层治理效能。     

顾客第一论

“顾客第一”有其特定的内涵,它充分体现社会主义企业的根本目的,因而是企业所有经营观念中的一个根本性观念,也是企业生产经营的一个根本指导思想。企业要实现其双重目的,促进物质文明和精神文明建设的发展,并树立各种现代经营观念,就必须坚持顾客第一。