依文思蓝与硫酸依替米星和硫酸奈替米星相互作用的共振瑞利散射光谱及其分析应用

在酸性条件下,酸性双偶氮染料依文思蓝(EB)和药物硫酸依替米星(ETS)、硫酸奈替米星(NETS)各自的共振瑞利散射(RRS)强度十分微弱,但EB与ETS或NETS两者相互作用形成的离子缔合物能显著提高RRS强度并产生新的RRS光谱,EB-ETS和EB-NETS体系均在350—400,680—730 nm有两个强的散射带,最大散射峰位于713 nm处.RRS强度分别与0.2—8.0μg/mL的ETS和0.4—8.0μg/mL的NETS呈线性关系,据此建立了ETS和NETS的测定方法.该方法有较好的选择性,用于市售ETS和NETS注射液中药物含量和临床血药浓度的快速测定,结果满意.     

基于投影的fMRI时间序列图像配准方法研究

利用投影技术,针对功能磁共振时间序列图像,介绍了一种新的自动图像配准方法。该方法将序列图像二值化后沿着水平方向或垂直方向进行投影,根据投影向量元素的位置和大小,快速地计算出图像的旋转、平移运动的变化参数。仿真实验和实际的功能磁共振应用证实了该方法的有效性。     

具有复合周期磁场的电子回旋脉塞

本文从降低回旋脉塞中直流磁场的角度出发,利用线性伏拉索夫——麦克斯韦方程组,对通过静态复合周期磁场的弱相对论电子注与缓变圆波导中沿纵向作任意缓变的TE_(mn)模式之间的互作用机理,在理论上进行了详细的分析和讨论,导出了色散方程并作了数值计算。分析和计算表明,由于采用了静态复合周期磁场,其电子注与波互作用的不稳定性产生在电子回旋共振条件下,从而可以在不同的电子回旋空间谐波上工作而大大地降低直流磁场。     

静电电子回旋脉塞的单粒子理论

本文用单粒子理论研究了静电电子回旋脉塞。通过对静电电子回旋脉塞中的电子运动的分析,导出了电子与波互作用的非线性摆方程。文中用二阶扰动方法求解非线性摆方程,得到了TE_(mn)和TM_(mn)两种工作模式的静电电子回旋脉塞不稳定性线性增益公式,进一步证实了静电电子回旋脉塞不稳定性是存在的。     

提高独立学院行政管理专业案例教学质量的对策思考

独立学院行政管理专业人才培养目标和学科特征决定了教师必须重视案例教学。但由于独立学院行政管理专业案例教学尚处于起步阶段,因此教师应与学生一同自主进行案例库建设,以此引起案例教学的”思维共振”,并引导学生将知识学习与能力提高有机结合。     

色噪声作用下耦合神经元网络的相干共振

研究了色噪声作用下耦合(FHN)神经元模型的相干共振现象。运用改进的四阶随机龙格-库塔法,计算了神经元膜电压分布和神经元点火峰峰间隔的变差系数。结果表明,神经元点火峰峰间隔的变差系数是色噪声强度、色噪声相关率和耦合神经元个数的非单调函数;存在最优的色噪声强度、色噪声相关率和耦合神经元个数,使得神经元点火峰峰间隔的变差系数出现极小值(即为相干共振)。讨论了色噪声强度、色噪声相关率和耦合神经元个数对系统相干性的影响。     

HIV-1gp41NHR序列靶点专一性的荧光共振能转移测定

目的确定并利用荧光共振能转移法（FRET）对以HIV-lgp41N端七联重复序列（NHR）为靶点的融合抑制剂进行筛选和作用机制研究。方法FRET采用金属络合物多肽技术设计针对不同结合位点、结合强度可调、涵盖全部NHR序列的靶点和探针,对HIV融合抑制剂进行高通量筛选。由于HIV在进行膜融合时其gp41的N端NHR和C端CHR可形成稳定的六螺旋结构,因此,利用圆二色谱仪对FRET所使用的靶点／探针对的结合强度进行验证,确定对应的靶点／探针对可形成稳定的六螺旋结构;同时,借助细胞活性测试测定抑制荆的活性,验证FRET是否可用于筛选以HIV-1gp41NHR为靶点的抑制剂。结果与结论FRET中使用的靶点／探针均可形成螺旋度较高的六螺旋结构,其中Fe（Env2．0）,／CP2及Fe（Env5．0）,／CP5形成的01．螺旋度分别高达89．6％和84．7％。FRET所使用的靶点／探针对专一性强、结合作用强,可用于进行HIV一1融合抑制剂的筛选和机制研究。     

The Benefits of Frame Resonance Disputes for Transnational Movements: The Case of Botswana's Central Kalahari Game Reserve

Internal rifts over framing and tactics often hinder groups from mobilizing the degree of support and resources necessary to achieve their stated goals. As a result of disparities in political culture and ideology, the existence of such rifts may be especially frequent and disabling for forms of transnational collective action. However, using the case of the transnational movement lobbying on behalf of Botswana's minority groups, particularly the indigenous San, this paper argues that frame resonance disputes can sometimes facilitate the achievement of a movement's immediate goals. This is for two main reasons. First, by appealing to different audiences, the movement can gain complementary and reinforcing forms of legitimacy and support. Second, states and their societies may possess different points of vulnerability, which can be more effectively targeted through the simultaneous use of multiple frames. By helping minority groups receive legal entitlement to their ancestral lands and opening a debate about the nature of Botswana's democracy, the transnational movement campaigning for the return of the Central Kalahari Game Reserve underscores the benefits of frame resonance disputes.     

Knowledge work and practices of seeing: Epistemologies of the eye,gaze, and professional vision

Much practice within organizations is to some extent embodied in and centered on the visual capacities of the agent, the acting subject. Distinguishing between ‘epistemologies of the eye’, i.e. theories of how knowledge is acquired through visual practices, and ‘practices of seeing’, i.e. theories and studies of how vision and visuality are actually used in everyday working life, the paper points to the need to understand vision and visuality in organizational practice. Using the case of functional magnetic resonance imaging (fMRI), it is suggested that professional vision, i.e. practices of seeing that are shared within epistemic communities, is firstly technologically mediated and, secondly, based on the ability to combine vision, speech, gesture, and other embodied and cognitive resources in order to make sense of the images produced by fMRI technology. The paper concludes that organization theory should examine practices of seeing in greater detail and as part of the project in order to understand how knowledge is constituted and used as a collectively constituted resource within organizations.     

Safety First: Recognizing and Managing the Risks to Child Participants in Magnetic Resonance Imaging Research

Specialized and up-to-date knowledge is required to identify and manage the risks associated with advanced biomedical research. Additional complexities need to be considered when the research involves infants or young children. In this article, we focus on recent information about the physical risks of pediatric magnetic resonance imaging research and highlight information gaps. With an eye to assisting institutional review boards and researchers, we consider strategies for the management of these risks and formulate key questions aimed at exposing hidden hazards. Institutional review boards should ask these questions, and researchers should bear them in mind as they develop research protocols.