Setting the clock back to zero property of a class of bivariate life distributions

In a previous paper. B. R. Rao and Talwalker (1993) considered absolutely continuous life distributions and extended the Lack of Memory Property (L.M.P.) of the exponential distribution and showed that several classes of life distributions have this property, which was called the 'setting the clock back to zero' property. ¶Its analog is discussed in the present paper for hivariate and multivariate classes of life distributions. As a simple application of this analog, it is proved that the Life expectancy and the Percentile Residual Life vectors of a population of individuals under the influence of multiple competing risks have simple expressions if the class of their joint life distributions has the setting the clock back to zero property,     

A Novel Method to Calculate Mean Survival Time for Time-to-Event Data

In the analysis of time-to-event data, restricted mean survival time has been well investigated in the literature and provided by many commercial software packages, while calculating mean survival time remains as a challenge due to censoring or insufficient follow-up time. Several researchers have proposed a hybrid estimator of mean survival based on the Kaplan–Meier curve with an extrapolated tail. However, this approach often leads to biased estimate due to poor estimate of the parameters in the extrapolated “tail” and the large variability associated with the tail of the Kaplan–Meier curve due to small set of patients at risk. Two key challenges in this approach are (1) where the extrapolation should start and (2) how to estimate the parameters for the extrapolated tail. The authors propose a novel approach to calculate mean survival time to address these two challenges. In the proposed approach, an algorithm is used to search if there are any time points where the hazard rates change significantly. The survival function is estimated by the Kaplan–Meier method prior to the last change point and approximated by an exponential function beyond the last change point. The parameter in the exponential function is estimated locally. Mean survival time is derived based on this survival function. The simulation and case studies demonstrated the superiority of the proposed approach.     

Small sample study on estimators of life distributions and of mean survival times using randomly censored data

Whereas large-sample properties of the estimators of survival distributions using censored data have been studied by many authors, exact results for small samples have been difficult to obtain. In this paper we obtain the exact expression for the ath moment (a > 0) of the Bayes estimator of survival distribution using the censored data under proportional hazard model. Using the exact expression we compute the exact mean, variance and MSE of the Bayes estimator. Also two estimators ofthe mean survival time based on the Kaplan-Meier estimator and the Bayes estimator are compared for small samples under proportional hazards.     

Analyzing Cohort Mortality Data

Several methods for analyzing data from mortality studies of occupationally or environmentally exposed cohorts are shown to be special cases of a single procedure. The procedure assumes a proportional hazards model for exposure effects and represents the log-likelihood kernel for the data as that of N independent Poisson variates, where N is the total number of person-units of mortality observation time in the study. It formalizes and justifies the epidemiological techniques of classifying deaths and person-months of study time into categories defined by exposure and other covariates, and of computing standardized mortality ratios and indirectly standardized death rates. Parameters representing exposure effects can be estimated by using standard software packages. Special cases and applications are described in the context of lung cancer mortality among U.S. uranium miners.     

Kullback–Leibler information of a censored variable and its applications

In this paper, we study the Kullback–Leibler (KL) information of a censored variable, which we will simply call it censored KL information. The censored KL information is shown to have the necessary monotonicity property in addition to inherent properties of nonnegativity and characterization. We also present a representation of the censored KL information in terms of the relative risk and study its relation with the Fisher information in censored data. Finally, we evaluate the estimated censored KL information as a goodness-of-fit test statistic.     

Combined multiple testing of multivariate survival times by censored empirical likelihood

In each study testing the survival experience of one or more populations, one must not only choose an appropriate class of tests, but further an appropriate weight function. As the optimal choice depends on the true shape of the hazard ratio, one is often not capable of getting the best results with respect to a specific dataset. For the univariate case several methods were proposed to conquer this problem. However, most of the interesting datasets contain multivariate observations nowadays. In this work we propose a multivariate version of a method based on multiple constrained censored empirical likelihood where the constraints are formulated as linear functionals of the cumulative hazard functions. By considering the conditional hazards, we take the correlation between the components into account with the goal of obtaining a test that exhibits a high power irrespective of the shape of the hazard ratio under the alternative hypothesis.     

Semiparametric Efficient Estimation in the Generalized Odds-Rate Class of Regression Models for Right-Censored Time-to-Event Data

The generalized odds-rate class of regression models for time to event data is indexed by a non-negative constant and assumes thatg(S(t|Z)) = (t) + Zwhere g(s) = log(^-1(s-) for > 0, g₀(s) = log(- log s), S(t|Z) is the survival function of the time to event for an individual with qx1 covariate vector Z, is a qx1 vector of unknown regression parameters, and (t) is some arbitrary increasing function of t. When =0, this model is equivalent to the proportional hazards model and when =1, this model reduces to the proportional odds model. In the presence of right censoring, we construct estimators for and exp((t)) and show that they are consistent and asymptotically normal. In addition, we show that the estimator for is semiparametric efficient in the sense that it attains the semiparametric variance bound.     

库切小说《耻》中白人的生存困境与历史宿命

为库切赢得诺贝尔文学奖奠定基础的《耻》是一部思想深刻的作品,小说以后种族隔离时代的南非为背景,讲述了白人卢里和露茜父女深陷生存困境的故事。他们的遭遇如实地展现了生活在新南非的白人如何一步步丧失话语权,陷入生存“耻”境,最终难逃历史性悲剧宿命的图景。故事背后隐藏着作者对人性的思索和对个体生命历史宿命的感悟。     

经济政策不确定性、企业出口生存与出口转内销

基于2000-2014年中国工业企业数据库、中国海关进出口数据库与Baker等编制的经济政策不确定性指数的匹配数据,本文实证研究了目的国经济政策不确定性对中国企业出口生存的影响。研究发现：目的国经济政策不确定性的提高显著增加了企业出口失败的概率;异质性分析发现,非国有企业、非东部地区企业,以及出口到高收入国家的企业受经济政策不确定性的影响更大;进一步分析发现,经济政策不确定性的提高显著促进了企业“出口转内销”,劳动密集型企业和一般贸易企业“出口转内销”的幅度更大。