Consideration of Background Exposures in the Management of Hazardous Waste Sites: A New Approach to Risk Assessment

The current approach to health risk assessment of toxic waste sites in the U.S. may lead to considerable expenditure of resources without any meaningful reduction in population exposure. Risk assessment methods used generally ignore background exposures and consider only incremental risk estimates for maximally exposed individuals. Such risk estimates do not address true public health risks to which background exposures also contribute. The purpose of this paper is to recommend a new approach to risk assessment and risk management concerning toxic waste sites. Under this new approach, which we have called public health risk assessment, chemical substances would be classified into a level of concern based on the potential health risks associated with typical national and regional background exposures. Site assessment would then be based on the level of concern for the particular pollutants involved and the potential contribution of site contaminants to typical background human exposures. While various problems can be foreseen with this approach, the key advantage is that resources would be allocated to reduce the most important sources of human exposure, and site remediation decisions could be simplified by focussing on exposure assessment rather than questionable risk extrapolations.     

Do you think that your health or safety are at risk because of your work? A large European study on psychological and physical work demands

Throughout Europe there are relatively few statistics, gathered a national level, which deal specifically with the problem of violence at work. In the UK, the revised Reporting of Injuries. Diseases and Dangerous Occurrences Regulations (RIDDOR) 1995 now require that certain violent incidents are reported on a national basis. The criteria for reporting, which are entirely dependent on the physical outcome of incidents, are discussed. It is recommended that employing organizations should establish their own internal systems for reportmg and recording a wider range of violent, and potentially violent, incidents. These should then be used to inform risk assessment and risk management.     

A Review of the High-Level Nuclear Waste Repository Siting Analysis

We critique two 1986 Department of Energy reports concerning the selection of sites for characterization as the nation's first high-level nuclear waste repository. We find that the multiattribute utility analysis of the five nominated sites was well done, although we express concern about the assessed probabilities, question the construction of two important attribute scales, and disagree with some of the value tradeoffs that were used. In contrast, we find the logic of the recommendations report to be weak and unconvincing.     

A Quantitative Estimate of Leukemia Mortality Associated with Occupational Exposure to Benzene3

In 1980, the U.S. Supreme Court vacated a revised occupational standard for benzene, stating that the Occupational Safety and Health Administration (OSHA) had failed to demonstrate that significant health risks existed under the current standard. This decision has been interpreted by OSHA as requiring the consideration of quantitative risk assessments, whenever possible, in the development of regulations for occupational carcinogens. In light of this decision, the available epidemiologic evidence was used to generate a quantitative risk assessment for benzene. Uncertainties regarding the levels and lengths of benzene exposure for the studied cohorts were incorporated into the analysis. Based on the one-hit model, the assessment indicates that a working lifetime exposure to benzene at the current permissible exposure level (10 ppm) poses a substantial excess risk of death from leukemia. This report discusses the calculation of the risk estimates, the basis for relying on certain assumptions, and the inherent limitations of using epidemiologic studies to quantify cancer risks.     

Leukemia Attributable to Residential Magnetic Fields: Results from Analyses Allowing for Study Biases

Nearly every epidemiologic study of residential magnetic fields and childhood leukemia has exhibited a positive association. Nonetheless, because these studies suffer from various methodologic limitations and there is no known plausible mechanism of action, it remains uncertain as to how much, if any, of these associations are causal. Furthermore, because the observed associations are small and involve only the highest and most infrequent levels of exposure, it is believed that the public health impact of an effect would be small. We present some formal analyses of the impact of power-frequency residential magnetic-field exposure (as measured by attributable fractions), accounting for our uncertainties about study biases as well as uncertainties about exposure distribution. These analyses support the idea that the public health impact of residential fields is likely to be limited, but both no impact and a substantial impact remain possibilities in light of the available data.     

Sensitivity Analysis of Model Output with Input Constraints: A Generalized Rationale for Local Methods

In this work, we introduce a generalized rationale for local sensitivity analysis (SA) methods that allows to solve the problems connected with input constraints. Several models in use in the risk analysis field are characterized by the presence of deterministic relationships among the input parameters. However, SA issues related to the presence of constraints have been mainly dealt with in a heuristic fashion. We start with a systematic analysis of the effects of constraints. The findings can be summarized in the following three effects. (i) Constraints make it impossible to vary one parameter while keeping all others fixed. (ii) The model output becomes insensitive to a parameter if a constraint is solved for that parameter. (iii) Sensitivity analysis results depend on which parameter is selected as dependent. The explanation of these effects is found by proposing a result that leads to a natural extension of the local SA rationale introduced in Helton (1993) . We then extend the definitions of the Birnbaum, criticality, and the differential importance measures to the constrained case. In addition, a procedure is introduced that allows to obtain constrained sensitivity results at the same cost as in the absence of constraints. The application to a nonbinary event tree concludes the article, providing a numerical illustration of the above findings.     

Expert Judgment-Based Risk Assessment Using Statistical Scenario Analysis: A Case Study—Running the Bulls in Pamplona (Spain)

In this article, we present a methodology to assess the risk incurred by a participant in an activity involving danger of injury. The lack of high-quality historical data for the case considered prevented us from constructing a sufficiently detailed statistical model. It was therefore decided to generate a risk assessment model based on expert judgment. The methodology is illustrated in a real case context: the assessment of risk to participants in a San Fermin bull-run in Pamplona (Spain). The members of the panel of "experts on the bull-run" represented very different perspectives on the phenomenon: runners, surgeons and other health care personnel, journalists, civil defense workers, security staff, organizers, herdsmen, authors of books on the bull-run, etc. We consulted 55 experts. Our methodology includes the design of a survey instrument to elicit the experts' views and the statistical and mathematical procedures used to aggregate their subjective opinions.     

企业如何建立科学的信用管理机制

信用销售是市场竞争的结果,加强信用管理是企业当务之急.企业必须建立科学的信用管理机制,成立信用管理部门,规范赊销行为,控制赊销风险.     

Runaway Reactions, Their Courses, and the Methods to Establish Safe Process Conditions

The purpose of this paper is to describe the various process deviations which can cause a runaway reaction to occur, and to discuss the experimental information necessary for risk assessment, the choice of a safe process, and the mitigation of the consequences of the runaway reaction. Ten typical hazardous process situations have been identified, considering various modes of initiation, homogeneous and heterogeneous, Arrhenius, and autocatalytic reactions. Each possible hazardous process deviation is illustrated by examples from the process industry and/or relevant experimental information obtained from laboratory experiments.