An Ecological Model for Quantitative Risk Assessment for Schistosomiasis: The Case of a Patchy Environment in the Coastal Tropical Area of Northeastern Brazil

We developed a stochastic model for quantitative risk assessment for the Schistosoma mansoni (SM) parasite, which causes an endemic disease of public concern. The model provides answers in a useful format for public health decisions, uses data and expert opinion, and can be applied to any landscape where the snail Biomphalaria glabrata is the main intermediate host (South and Central America, the Caribbean, and Africa). It incorporates several realistic and case‐specific features: stage‐structured parasite populations, periodic praziquantel (PZQ) drug treatment for humans, density dependence, extreme events (prolonged rainfall), site‐specific sanitation quality, environmental stochasticity, monthly rainfall variation, uncertainty in parameters, and spatial dynamics. We parameterize the model through a real‐world application in the district of Porto de Galinhas (PG), one of the main touristic destinations in Brazil, where previous studies identified four parasite populations within the metapopulation. The results provide a good approximation of the dynamics of the system and are in agreement with our field observations, i.e., the lack of basic infrastructure (sanitation level and health programs) makes PG a suitable habitat for the persistence and growth of a parasite metapopulation. We quantify the risk of SM metapopulation explosion and quasi‐extinction and the time to metapopulation explosion and quasi‐extinction. We evaluate the sensitivity of the results under varying scenarios of future periodic PZQ treatment (based on the Brazilian Ministry of Health's plan) and sanitation quality. We conclude that the plan might be useful to slow SM metapopulation growth but not to control it. Additional investments in better sanitation are necessary.     

Bayesian Treatment of Model Uncertainty for Partially Applicable Models

This article discusses how analyst's or expert's beliefs on the credibility and quality of models can be assessed and incorporated into the uncertainty assessment of an unknown of interest. The proposed methodology is a specialization of the Bayesian framework for the assessment of model uncertainty presented in an earlier paper. This formalism treats models as sources of information in assessing the uncertainty of an unknown, and it allows the use of predictions from multiple models as well as experimental validation data about the models’ performances. In this article, the methodology is extended to incorporate additional types of information about the model, namely, subjective information in terms of credibility of the model and its applicability when it is used outside its intended domain of application. An example in the context of fire risk modeling is also provided.     

Risk Assessment for Hospital-Acquired Diseases: A Risk-Theory Approach

We introduce a new approach to hospital-acquired disease risk assessment from public health databases. In a spirit similar to actuarial risk theory, we define an adjustment coefficient that can quantify the risk associated with a hospital department, allowing comparisons of similar departments. The adjustment coefficient characterizes the tail of the distribution of the total patient length of stay in a department before the first disease event occurs. We show that this coefficient is the solution of a Lundberg-like equation, and we provide a nonparametric estimation procedure for this measure, based on a Cramér-Lundberg approximation for the tail of the distribution. Using simulations, we provide evidence of the robustness of the approximation to various individual risk models. In addition, we illustrate the relevance of this approach by evaluating the risk associated with a standard patient safety indicator in 20 hospitals of southeastern France.     

Human Health Risk Assessment of Penicillin/Aminopenicillin Resistance in Enterococci Due to Penicillin Use in Food Animals

Penicillin and ampicillin drugs are approved for use in food animals in the United States to treat, control, and prevent diseases, and penicillin is approved for use to improve growth rates in pigs and poultry. This article considers the possibility that such uses might increase the incidence of ampicillin-resistant Enterococcus faecium (AREF) of animal origin in human infections, leading to increased hospitalization and mortality due to reduced response to ampicillin or penicillin. We assess the risks from continued use of penicillin-based drugs in food animals in the United States, using several assumptions to overcome current scientific uncertainties and data gaps. Multiplying the total at-risk population of intensive care unit (ICU) patients by a series of estimated factors suggests that not more than 0.04 excess mortalities per year (under conservative assumptions) to 0.14 excess mortalities per year (under very conservative assumptions) might be prevented in the whole U.S. population if current use of penicillin drugs in food animals were discontinued and if this successfully reduced the prevalence of AREF infections among ICU patients. These calculations suggest that current penicillin usage in food animals in the United States presents very low (possibly zero) human health risks.     

累积的异质性：生命历程视角下的老年人分化

本文以生命历程理论为研究视角，以深度访谈的方法收集老年人“主诉”的关于过去的生活资料，试图通过对个人能动性与生命历程时间性的强调，来分析个体生命历程与社会变迁的相互嵌入过程，以及这一过程中不断分化的内部机制。研究发现，老化的过程是一个随时间推移不断累积与分化的过程，累积因素的先后顺序对个体之间的分化具有重要意义，累积是生命历程资本遭遇生命历程风险的结果，是社会结构与个人能动性相互作用的动态过程，其中社会政策的变迁对累积过程具有决定性的影响。     

Parameter estimation of Lindley step stress model with independent competing risk under type 1 censoring

Abstract

In literature, Lindley distribution is considered as an alternative to exponential distribution to fit lifetime data. In the present work, a Lindley step-stress model with independent causes of failure is proposed. An algorithm to generate random samples from the proposed model under type 1 censoring scheme is developed. Point and interval estimation of the model parameters is carried out using maximum likelihood method and percentile bootstrap approach. To understand the effectiveness of the resulting estimates, numerical illustration is provided based on simulated and real-life data sets.     

Analysis of some ruin-related quantities in a Markov-modulated risk model

In this paper, we study the joint Laplace transform and probability generating function of some random quantities that occur in each environment state by the time of ruin in a Markov-modulated risk process. These quantities include the duration spent in each state, the number of claims and the aggregate amount of claims that occurred in each state by the time of ruin. Explicit formulae for the joint transforms, given the initial surplus, and the initial and terminal environment states, are expressed in terms of a matrix version of the scale function. Moments and covariances of these ruin-related quantities are obtained and numerical illustrations are presented. The joint transform of the duration spent in each state, the number of claims, and the aggregate amount of claims that occurred in each state by the time the surplus attains a certain level are also investigated.     

On conditional risk estimation considering model risk

Usually, parametric procedures used for conditional variance modelling are associated with model risk. Model risk may affect the volatility and conditional value at risk estimation process either due to estimation or misspecification risks. Hence, non-parametric artificial intelligence models can be considered as alternative models given that they do not rely on an explicit form of the volatility. In this paper, we consider the least-squares support vector regression (LS-SVR), weighted LS-SVR and Fixed size LS-SVR models in order to handle the problem of conditional risk estimation taking into account issues of model risk. A simulation study and a real application show the performance of proposed volatility and VaR models.     

Gambling Behavior of Student-Athletes and a Student Cohort: What are the Odds?

This study investigated the prevalence of gambling, gambling related NCAA violations, and disordered gambling in student-athletes (n = 736) with a comparison cohort of students (n = 1,071) at four universities. Student-athletes reported similar rates of gambling frequency, use of a bookmaker, and disordered gambling as students. After accounting for demographic differences, student-athletes were less likely to engage in sports wagering than students. Several risk factors for disordered gambling were identified, including being male and reporting at least one parent with a history of gambling problems. These findings suggest that problems associated with gambling are a university-wide issue with student-athletes meriting additional attention because of implications for the integrity of intercollegiate sports. Improved prevention and intervention efforts for collegiate gambling are recommended.