中国节节麦的细胞遗传学研究及有关问题探讨

应用染色体组分析法,对新疆节节麦、黄河流域节节麦、伊朗节节麦和中东节节麦的D染色体组进行了较系统的比较分析,结果表明:新疆节节麦与伊朗、中东两地节节麦在染色体组水平上无明显差异,其差异仅体现在染色体的细微结构组成上;臂内倒位是引起染色体结构组成上细微分化的主要原因。黄河流域节节麦与新疆节节麦的染色体组极为相近;其D组染色体无论在染色体组水平上,还是在染色体细微结构组成上均无差异。本文还就中国节节麦与中国特有六倍体普通小麦的起源演化,中国节节麦种质资源在现代小麦育种中的应用等问题进行了讨论。     

A Note on Inconsistency of NPMLE of the Distribution Function from Left Truncated and Case I Interval Censored Data

We show that under reasonable conditions the nonparametric maximum likelihood estimate (NPMLE) of the distribution function from left-truncated and case 1 interval-censored data is inconsistent, in contrast to the consistency properties of the NPMLE from only left-truncated data or only interval-censored data. However, the conditional NPMLE is shown to be consistent. Numerical examples are provided to illustrate their finite sample properties.     

Aalen's Linear Model for Sampled Risk Set Data: A Large Sample Study

Borgan and Langholz (1997) describe a method for estimating the parameter functions in Aalen's linear hazard regression model from sampled risk set data. Using a counting process formulation and the martingale central limit theorem, we provide a study of the asymptotic distributional properties of the estimator. The results are applied to study the efficiencies of the nested case-control and counter-matched designs relative to a full cohort analysis.     

Using quantile averages in matched observational studies

In two observational studies, one investigating the effects of minimum wage laws on employment and the other of the effects of exposures to lead, an estimated treatment effect's sensitivity to hidden bias is examined. The estimate uses the combined quantile averages that were introduced in 1981 by B. M. Brown as simple, efficient, robust estimates of location admitting both exact and approximate confidence intervals and significance tests. Closely related to Gastwirth's estimate and Tukey's trimean, the combined quantile average has asymptotic efficiency for normal data that is comparable with that of a 15% trimmed mean, and higher efficiency than the trimean, but it has resistance to extreme observations or breakdown comparable with that of the trimean and better than the 15% trimmed mean. Combined quantile averages provide consistent estimates of an additive treatment effect in a matched randomized experiment. Sensitivity analyses are discussed for combined quantile averages when used in a matched observational study in which treatments are not randomly assigned. In a sensitivity analysis in an observational study, subjects are assumed to differ with respect to an unobserved covariate that was not adequately controlled by the matching, so that treatments are assigned within pairs with probabilities that are unequal and unknown. The sensitivity analysis proposed here uses significance levels, point estimates and confidence intervals based on combined quantile averages and examines how these inferences change under a range of assumptions about biases due to an unobserved covariate. The procedures are applied in the studies of minimum wage laws and exposures to lead. The first example is also used to illustrate sensitivity analysis with an instrumental variable.     

Detecting a changed segment in DNA sequences

Non-coding deoxyribonucleic acid (DNA) can typically be modelled by a sequence of Bernoulli random variables by coding one base, e.g. T, as 1 and other bases as 0. If a segment of a sequence is functionally important, the probability of a 1 will be different in this changed segment from that in the surrounding DNA. It is important to be able to see whether such a segment occurs in a particular DNA sequence and to pin-point it so that a molecular biologist can investigate its possible function. Here we discuss methods for testing the occurrence of such a changed segment and how to estimate the end points of it. Maximum-likelihood-based methods are not very tractable and so a nonparametric method based on the approach of Pettitt has been developed. The problem and its solution are illustrated by a specific DNA example.     

Weighted Approximations to Continuous Time Martingales with Applications

A weighted approximation to a sequence of continuous time martingales by a time transformed Wiener process is established. The basic tool of proof is the Skorohod imbedding for martingale difference sequences. As an application of the main result a useful weighted approximation to the randomly weighted uniform empirical process is derived. A number of other applications are also discussed.     

Semiparametric Additive Accelerated Life Models

In this paper we investigate the asymptotic properties of estimators obtained for the semiparametric additive accelerated life model proposed by Bagdonavicius & Nikulin (1995). This model generalizes the well known additive hazards model of survival analysis and is close to the general transformation model (see Dabrowska & Doksum, 1988). Asymptotic properties of the estimator of the regression parameter and the estimator of the reliability function are given in the case of right censoring for discretized data and a numerical example illustrates these results.     

Efficacy of programmes for the unemployed: discrete time modelling of duration data from a matched-comparison study

An evaluation is described of two UK Government programmes for the long-term unemployed in Great Britain, Employment Training and Employment Action, using discrete time hazard modelling of event histories. The study design employed a closely matched comparison group and carefully chosen control variables to minimize the effect of selection bias on conclusions. The effect of unobserved heterogeneity is investigated by using some standard random effect model formulations.     

Biased Bootstrap Methods for Reducing the Effects of Contamination

Contamination of a sampled distribution, for example by a heavy-tailed distribution, can degrade the performance of a statistical estimator. We suggest a general approach to alleviating this problem, using a version of the weighted bootstrap. The idea is to 'tilt' away from the contaminated distribution by a given (but arbitrary) amount, in a direction that minimizes a measure of the new distribution's dispersion. This theoretical proposal has a simple empirical version, which results in each data value being assigned a weight according to an assessment of its influence on dispersion. Importantly, distance can be measured directly in terms of the likely level of contamination, without reference to an empirical measure of scale. This makes the procedure particularly attractive for use in multivariate problems. It has several forms, depending on the definitions taken for dispersion and for distance between distributions. Examples of dispersion measures include variance and generalizations based on high order moments. Practicable measures of the distance between distributions may be based on power divergence, which includes Hellinger and Kullback–Leibler distances. The resulting location estimator has a smooth, redescending influence curve and appears to avoid computational difficulties that are typically associated with redescending estimators. Its breakdown point can be located at any desired value ε∈ (0, ½) simply by 'trimming' to a known distance (depending only on ε and the choice of distance measure) from the empirical distribution. The estimator has an affine equivariant multivariate form. Further, the general method is applicable to a range of statistical problems, including regression.     

On the relative accuracy of certain bootstrap procedures

We show the second-order relative accuracy, on bounded sets, of the Studentized bootstrap, exponentially tilted bootstrap and nonparametric likelihood tilted bootstrap, for means and smooth functions of means. We also consider the relative errors for larger deviations. Our method exploits certain connections between Edgeworth and saddlepoint approximations to simplify the computations.