排序方式: 共有57条查询结果,搜索用时 15 毫秒
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In recent years, seamless phase I/II clinical trials have drawn much attention, as they consider both toxicity and efficacy endpoints in finding an optimal dose (OD). Engaging an appropriate number of patients in a trial is a challenging task. This paper attempts a dynamic stopping rule to save resources in phase I/II trials. That is, the stopping rule aims to save patients from unnecessary toxic or subtherapeutic doses. We allow a trial to stop early when widths of the confidence intervals for the dose-response parameters become narrower or when the sample size is equal to a predefined size, whichever comes first. The simulation study of dose-response scenarios in various settings demonstrates that the proposed stopping rule can engage an appropriate number of patients. Therefore, we suggest its use in clinical trials. 相似文献
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余宏 《安徽理工大学学报(社会科学版)》2021,23(1):103-108
文化记忆媒介经历多次嬗变,从口述媒介、书写媒介、印刷媒介到当下的数字媒介.媒介嬗变为文化记忆当下化提供了基本的结构框架,尤其是数字媒介,对文化记忆的储存、传播和表现产生了诸多新影响.首先,它极大地提升了文化记忆的储存能力,也产生了"数字黑暗时代"问题;其次,它有利于传播个体关于文化记忆的观点和评价,放大了各群体间关于文... 相似文献
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王文彬 《西北农林科技大学学报(社会科学版)》2021,21(1):52-59
确保乡村振兴无缝链接脱贫攻坚,已经成为全社会和学术界关注的焦点问题。着眼整体治理视角可知,脱贫攻坚转向乡村振兴呈现出了"由点及面"的特征,包括治理对象扩大化、治理任务丰富化、治理场域拓展化、治理资源全面化和治理思维合作化等内容。当然,从脱贫攻坚到乡村振兴依然有着较多治理任务延续,如产业振兴立足扶贫产业发展、振兴主体队伍吸纳扶贫人才、文化振兴承袭扶贫扶智工作、组织振兴借鉴扶贫行动架构以及振兴机制传承扶贫治理经验。同时,为了开展更高质量的乡村振兴工作,也要推进较多的治理升级,既要依托乡村振兴发展消解相对贫困,借助多元主体合作改变治理思维,也要积极尝试乡村振兴区域合作模式,并系统构建完整的乡村振兴制度体系。 相似文献
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Jessica L. Dunning-Lozano 《Race Ethnicity and Education》2016,19(2):433-460
This qualitative case-study explores questions about the stratifying role of public alternative schools created for ‘at-risk’ youth by analyzing the school experience of students who attend a single continuation high school and the process of student enrollment and referral to that school. Drawing on the concept of whiteness as property, this article demonstrates how the continuation high school maintained and protected the property functions of whiteness through acts of symbolic violence and the systematic removal of non-white students from the school district’s mainstream high school. Instead, students were placed in a substandard alternative school lacking in material and intellectual resources. Furthermore, teachers, counselors, and administrative staff at the mainstream and continuation high schools alike drew upon the racial ideology of merit to rationalize the overrepresentation of non-white youths at the study school and to ‘deracialize’ the student referral process. 相似文献
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肖雪 《西昌学院学报(社会科学版)》2015,(2):99-102
凉山彝族毕摩宗教仪式除了独特的宗教和文化特性外,还具有其他传统教育类型无可替代的教育内涵和功
能。凉山彝族人正是通过这种集体性的参与,深受演绎场域的熏陶,保存和丰富着村落的集体记忆,增强了社会成员之间的凝
聚力,同时也承继了彝族的传统文化。 相似文献
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美国霸权:衰落还是延续 总被引:2,自引:1,他引:1
自20世纪50年代以来,历史上共出现了大约五次美国霸权衰落论。几乎每次衰落论都遭到霸权延续论的反击。"9.11"事件、"他者的崛起"、金融危机引发了新一轮的美国霸权衰落论与延续论之间的争论。然而,美国霸权的真实现状是美国的硬实力依然坚挺,遭受重创的只是美国的软实力。凭借美元霸权的融资能力、国民的忧患意识和政策的改弦易辙,美国照样能够渡过难关,并在相当长时期内延续其霸权。 相似文献
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蒋琪发 《深圳大学学报(人文社会科学版)》2000,17(3):103-108
为适应我国经济发展需要,对21世纪的会计后继教育目标、要求、内容、形式、制度和管理体制等问题进行探讨,旨在促进有关部门加大会计改革力度,优化会计后继教育环境,以全面提高会计人员素质. 相似文献