代谢综合征基础与临床系列研究——GRGDSP/7E3对动脉粥样硬化内皮细胞MMPs的mRNA表达的影响

目的了解GRGDSP/7E3对基质金属蛋白酶（MMP-2,MMP-9）mRNA表达的影响。方法体外培养人脐静脉内皮细胞,分别用酶谱法和逆转录聚合酶链式反应（RT-PCR）检测MMP-2,MMP-9活性和mRNA表达。待细胞融合成单层后,分别加入无血清培养基、静息期血小板、活化后血小板及interleukin-1β（IL-1β）,共同培养60min后,洗去血小板,内皮细胞继续培养6h。上清液及细胞分别用于酶谱法检测MMP-2和MMP-9活性,以及RT-PCR分析mRNA表达。结果内皮细胞与活化血小板共同培养后,酶谱法显示：与对照组相比,未活化的血小板轻微诱导MMP-2和MMP-9分泌,而活化状态的血小板能显著诱导这二者的分泌,与IL-1β的作用相当;而且还可以见到62kDaMMP-2活化形式。加入阻断剂GRGDSP以及GPⅡb/Ⅲa单克隆抗体（7E3）作用后检测发现,MMP-2和MMP-9分泌减少。与活化血小板共同培养后的内皮细胞表面表达uPAR和MT1-MMP以及上清液中MMP-2的mRNA与对照组相比明显增高,而静息状态的血小板作用不显著。加入GRGDSP或7E3后,mR-NA的表达降低。结论①活化状态的血小板与IL-1β的作用相当,能显著诱导MMP-2和MMP-9分泌;能明显增高内皮细胞（EC）-uPAR和MT1-MMP及上清液中MMP-2mRNA的表达;②GPⅡb/Ⅲa阻断剂可能抑制血小板在不稳定斑块部位聚集、粘附等一系列炎症反应。     

界面构象对共聚物-(PPP)_m-(PT)_n-光学性质的影响

采用半经验的AM1方法研究了共聚物-(PPP)m-(PT)n-中性态和带电态的稳定构型,中性态下界面处的扭转角为25°时构型最稳定,带电态下界面处的扭转角为0°时构型最稳定.在AM1优化的基础上采用ZINDO方法研究共聚物界面处构象的改变对其光吸收性质的影响,计算发现共聚物-(PPP)m-(PT)n-的电子光吸收谱将依赖于界面处扭转角的变化,扭转角从0°到90°变化时,中性态下第一、二、三激发跃迁能随扭转角的增加而增加,而且随分子链长的变短和含苯环比例的增大,此种变化趋势越显著;在掺杂两个电荷的情况下,第一、二、三激发跃迁能随扭转角的增加而减小.     

一类非线性混合整规划的无约束连续化解法

将整系数多项式 0 - 1混合整规划问题化成无约束多项式规划问题。通过解该问题 ,能得到原问题的近似解。处理方法的特点是能够直接处理不等式约束情形 ,而不需要先将不等式约束化成等式约束再来处理     

Block external bootstrap in partially linear models with nonstationary strong mixing error terms

The authors extend the block external bootstrap to partially linear regression models with strongly mixing, nonstationary error terms. In addition to providing an approximate distribution for the semiparametric least square estimator of the parametric component, they propose a consistent estimator of the co‐variance matrix of this estimator.     

Applicability of a Neuroprobabilistic Integral Risk Index for the Environmental Management of Polluted Areas: A Case Study

Recently, we developed a GIS-Integrated Integral Risk Index (IRI) to assess human health risks in areas with presence of environmental pollutants. Contaminants were previously ranked by applying a self-organizing map (SOM) to their characteristics of persistence, bioaccumulation, and toxicity in order to obtain the Hazard Index (HI). In the present study, the original IRI was substantially improved by allowing the entrance of probabilistic data. A neuroprobabilistic HI was developed by combining SOM and Monte Carlo analysis. In general terms, the deterministic and probabilistic HIs followed a similar pattern: polychlorinated biphenyls (PCBs) and light polycyclic aromatic hydrocarbons (PAHs) were the pollutants showing the highest and lowest values of HI, respectively. However, the bioaccumulation value of heavy metals notably increased after considering a probability density function to explain the bioaccumulation factor. To check its applicability, a case study was investigated. The probabilistic integral risk was calculated in the chemical/petrochemical industrial area of Tarragona (Catalonia, Spain), where an environmental program has been carried out since 2002. The risk change between 2002 and 2005 was evaluated on the basis of probabilistic data of the levels of various pollutants in soils. The results indicated that the risk of the chemicals under study did not follow a homogeneous tendency. However, the current levels of pollution do not mean a relevant source of health risks for the local population. Moreover, the neuroprobabilistic HI seems to be an adequate tool to be taken into account in risk assessment processes.     

矩阵方程XA＝B的亚（半）正定自共轭四元数矩阵解

给出了四元数体Ｑ上ｎ×ｎ分块矩阵为亚（半）正定自共轭矩阵的一个充要条件，进而给出了Ｑ上矩阵方程ＸＡｎｍ＝Ｂｎｍ有亚（半）正定自共轭四元数矩阵解的充要条件及解集合的显式表示，从而推广改进了数城上线性方程组的反问题及矩阵反问题的相应结果．     

La médiane simpliciale d'Oja: Existence,unicité et stabilité

Oja (1983) examined various ways of measuring location, scatter, skewness, and kurtosis for multivariate distributions. Among other measures of location, he introduced a generalised median known in this paper under the name of the Oja median. In our study of the existence of that median, we show that Oja's definition can only be applied to distributions having a mean. In dimension d θ 2, we establish that the usual method of extension breaks down, which raises the question of the validity of the concept as a notion of median. Two fundamental theoretical properties of that median are also considered: uniqueness and consistency.     

PES-C,(PP/Bis-T)PES的次级松驰与转变

描述了酚酞型聚芳醚砜(PES-C)的次级松驰和转变与其结构的关系.TBA和动态力学实验结果表明:PES-C及其共聚物(PP/Bis-T)PES分别在0～50℃和-100℃附近呈现出两个次级松驰峰;双酚T单元的引入导致了PES-C在0～50℃之间的次级松驰位置改变.证实了Cardo侧基的存在对-100℃的次级松驰有较大的贡献.     

“蚤”是本有其字的假借吗

传统的观点认为,“蚤”是本有其字的假借,它的本字“早”产生于“蚤”之前。近十几年提出的观点认为,“早”产生于“蚤”之后,“蚤”是本无其字的假借。作者经过研究认为,“蚤”仅仅是个有本字的假借字,至于它的本字产生先后并不能确切地断定。     

拓扑型KKM定理和Riesz空间中的极大极小定理

证明了广义区间空间中几个新的参数型KKM定理,由此得到了Riesz空间中几个新型极大极小定理。