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11.
Bernard Sébastien David Hoffman Clémence Rigaux Franck Pellissier Jérôme Msihid 《Pharmaceutical statistics》2016,15(6):450-458
This article describes how a frequentist model averaging approach can be used for concentration–QT analyses in the context of thorough QTc studies. Based on simulations, we have concluded that starting from three candidate model families (linear, exponential, and Emax) the model averaging approach leads to treatment effect estimates that are quite robust with respect to the control of the type I error in nearly all simulated scenarios; in particular, with the model averaging approach, the type I error appears less sensitive to model misspecification than the widely used linear model. We noticed also few differences in terms of performance between the model averaging approach and the more classical model selection approach, but we believe that, despite both can be recommended in practice, the model averaging approach can be more appealing because of some deficiencies of model selection approach pointed out in the literature. We think that a model averaging or model selection approach should be systematically considered for conducting concentration–QT analyses. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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Thiel D 《The British journal of sociology》2007,58(2):227-251
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Min‐Kyoung Rhee Soo Kyung Park Chung‐Kwon Lee 《International Journal of Social Welfare》2020,29(1):51-61
This study examined the prevalence of workplace flexibility and the mechanisms that allow workplace flexibility to influence turnover intentions through work–family and family–work conflicts and job satisfaction among low‐wage workers in South Korea. Participants included 250 low‐wage workers whose monthly salary was less than 2 million Korean won (approx. $1,900). The study results indicate that low‐wage workers have limited access to workplace flexibility and that workplace flexibility plays a significant protective role in reducing their turnover intention, indirectly by decreasing work–family conflicts and enhancing job satisfaction. This article also discusses the implications of these findings for labor policy and social work practice. 相似文献
14.
As the population of Chinese immigrants has been growing rapidly in the United States, it has been understudied on the parenting behaviours as well as the roles parental stress and social support playing in parenting in this group. This study investigated whether parental stress was associated with parenting and whether this relationship was mediated by social support in a sample of 255 Chinese immigrant parents from the Survey of Asian American Families in New York City. Regression analyses with a rich array of control variables found that a higher level of parental stress and the presence of one or more stressors such as unemployment, low income, and low education were positively associated with the use of harsh discipline and parent–child conflicts and negatively associated with positive parenting practices. Social support functioned as a significant mediator in the relationships between parental stress and positive parenting practices but not in the relationships of parental stress with parent–child conflict or the use of harsh discipline. 相似文献
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Byungwon Kim Stephan Huckemann Jrn Schulz Sungkyu Jung 《Scandinavian Journal of Statistics》2019,46(4):1047-1071
We propose novel parametric concentric multi‐unimodal small‐subsphere families of densities for p ? 1 ≥ 2‐dimensional spherical data. Their parameters describe a common axis for K small hypersubspheres, an array of K directional modes, one mode for each subsphere, and K pairs of concentrations parameters, each pair governing horizontal (within the subsphere) and vertical (orthogonal to the subsphere) concentrations. We introduce two kinds of distributions. In its one‐subsphere version, the first kind coincides with a special case of the Fisher–Bingham distribution, and the second kind is a novel adaption that models independent horizontal and vertical variations. In its multisubsphere version, the second kind allows for a correlation of horizontal variation over different subspheres. In medical imaging, the situation of p ? 1 = 2 occurs precisely in modeling the variation of a skeletally represented organ shape due to rotation, twisting, and bending. For both kinds, we provide new computationally feasible algorithms for simulation and estimation and propose several tests. To the best knowledge of the authors, our proposed models are the first to treat the variation of directional data along several concentric small hypersubspheres, concentrated near modes on each subsphere, let alone horizontal dependence. Using several simulations, we show that our methods are more powerful than a recent nonparametric method and ad hoc methods. Using data from medical imaging, we demonstrate the advantage of our method and infer on the dominating axis of rotation of the human knee joint at different walking phases. 相似文献
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Bartlett correction constitutes one of the attractive features of empirical likelihood because it enables the construction of confidence regions for parameters with improved coverage probabilities. We study the Bartlett correction of spatial frequency domain empirical likelihood (SFDEL) based on general spectral estimating functions for regularly spaced spatial data. This general formulation can be applied to testing and estimation problems in spatial analysis, for example testing covariance isotropy, testing covariance separability as well as estimating the parameters of spatial covariance models. We show that the SFDEL is Bartlett correctable. In particular, the improvement in coverage accuracies of the Bartlett‐corrected confidence regions depends on the underlying spatial structures. The Canadian Journal of Statistics 47: 455–472; 2019 © 2019 Statistical Society of Canada 相似文献
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Heng Qu 《Nonprofit management & leadership》2019,30(2):193-212
This study uses modern portfolio theory (MPT) to estimate the risk of nonprofit revenue portfolios and examines to what degree the revenue concentration measure based on Herfindahl–Hirschman Index is associated with the portfolio risk measure based on MPT. The findings suggest that nonprofits with greater revenue concentration have lower revenue portfolio risk in the whole sample analysis. However, it is plausible that this result is dominated by organizations reliant on commercial income, which comprise over half of the sample. In fact, when examined separately, the relationship varies by an organization's primary funding structure. While higher revenue concentration is positively associated with portfolio risk for organizations relying on donations or those without a consistent primary funding source, it appears to associate with a lower portfolio risk for commercial organizations and those relying on government grants. This study reflects on the concept of diversification derived from portfolio theory and calls attention to a more nuanced approach to nonprofit revenue strategy. 相似文献