Estimation of Metabolic Rate Constants in PBPK‐Models from Liver Slice Experiments: What Are the Experimental Needs?

A mechanistic model is presented describing the clearance of a compound in a precision-cut liver slice that is incubated in a culture medium. The problem of estimating metabolic rate constants in PBPK models from liver slice experiments is discussed using identifiability analysis. From the identifiability problem analysis, it appears that in addition to the clearance, the compound's free fraction in the slice and the diffusion rate of the exchange of the compound between culture medium and liver slice should be identified. In addition, knowledge of the culture medium volume, the slice volume, the compound's free fraction, and octanol-water-based partition between medium and slice is presupposed. The formal solution for identification is discussed from the perspective of experimental practice. A formally necessary condition for identification is the sampling of parent compound in liver slice or culture medium. However, due to experimental limitations and errors, sampling the parent compound in the slice together with additional sampling of metabolite pooled from the medium and the slice is required for identification in practice. Moreover, it appears that identification results are unreliable when the value of the intrinsic clearance exceeds the value of the diffusion coefficient, a condition to be verified a posteriori.     

对张学良联共抗日思想形成的几点思考

指出中华民族的千古功臣张学良将军,是中国共产党人的一位真正朋友。论述了张学良联共抗日的思想基础、形成及其实现联共抗日的途径。同时,对张学良联共抗日思想与行动进行了评析,从而为学术界进一步研究和评价张学良将军与中国共产党人的关系提供了借鉴。     

《高等代数》教程之我见

《高等代数》是一门普遍让学生感到头疼的课,这与所用教材的教程有一定关系,本文就目前所用的教材提出了一种较为适宜的教程,并论述了实施它的可能性与有利因素.     

Cognitive and interpersonal abilities related to the primary activities of R&D managers

This study attempted to identify the primary activities performed by R&D managers at different supervisory levels, and the cognitive and interpersonal ability requirements that underlie these activities. A task inventory containing 244 managerial tasks was completed by 117 R&D managers in nine organizations. The 48 tasks which managers rated as having spent the most time were factor analyzed, resulting in the identification of three primary activities: project management, personnel supervision, and strategic planning. Furthermore, these activities varied with supervisory level, with R&D managers performing a wider range of these activities with the progression from first-line to upper-level management.Thirty R&D managers later rated the degree to which 19 cognitive and interpersonal abilities were required for performing these primary activities. Strategic planning was rated as requiring significantly higher levels of oral expression, logical reasoning, originality, fluency of ideas, oral defense, and resistance to premature judgement than was required for the other two primary activities. Personnel supervision required a higher level of social sensitivity than was required for the other two activities. Project management required high levels of information ordering, oral fact- finding ability, problem sensitivity, and oral and written comprehension. Implications of the findings for understanding R&D managerial performance and personnel staffing functions are discussed.     

层次分析法在电信企业管理诊断中的应用

本文阐述了电信企业诊断的特点及综合评价指标体系的确立 ,给出了AHP法在电信企业管理诊断中的具体应用 ,从定量分析的角度 ,分析了电信企业在经营管理中存在的问题和不足。     

地方矿产资源规划研究的一般理论

矿产资源规划是保证矿产资源安全的重要措施。本文论述了地方矿产资源规划的产生原因、发展过程和要解决的基本问题,介绍了矿产资源规划的主要内容和编制方法。     

高精度渗碳控制方法

在采用电阻法直接测控碳势的方法中,提出了一种分段参数调节增量式PID算法,通过实际调试和理论推导表明,渗碳工艺过程控制具有控制超调量小、过渡时间短、精度高、软件实现方便等优点,稳定后碳势控制精度可达±0.03%。     

论高校思想政治理论课程建设

搞好对高校思想政治理论课程建设,需要厘清课程建设的内涵,把教材建设和教法建设作为着力点,并为课程建设的中心问题———教育教学的实效性服务。     

加拿大高等教育的特色与启示

加拿大高等教育的特点主要体现在管理体制和教育教学两个方面,包括:联邦政府不设教育部;分为大学和学院两个系统;多样化的联合办学模式;完全学分制;宽口径厚基础的课程体系;启发式的教学模式,等等.加拿大高等教育给予我们的启示有:树立以人为本的办学理念,实施完全学分制;理性思考学校定位,开展多渠道合作办学;整体优化培养方案,实施启发式教学方法;建立科学的高校内部评价体系,等等.     

中国传统修辞学的继承

20世纪初诞生的中国现代修辞学,较多地受西方修辞理论的影响。要提高修辞学的品位与社会功用,就必须继承中国修辞学传统,建立具有民族特色的修辞学体系,重视中国古代修辞学学术传统,重新考虑修辞学的内容与体系、方法与方法论等问题。