Flexible univariate and multivariate models based on hidden truncation

A broad spectrum of flexible univariate and multivariate models can be constructed by using a hidden truncation paradigm. Such models can be viewed as being characterized by a basic marginal density, a family of conditional densities and a specified hidden truncation point, or points. The resulting class of distributions includes the basic marginal density as a special case (or as a limiting case), but also includes an array of models that may unexpectedly include many well known densities. Most of the well known skew-normal models (developed from the seed distribution popularized by Azzalini [(1985). A class of distributions which includes the normal ones. Scand. J. Statist. 12(2), 171–178]) can be viewed as being products of such a hidden truncation construction. However, the many hidden truncation models with non-normal component densities undoubtedly deserve further attention.     

高校体育图书资料的管理与利用

高校体育图书资料是高校图书资料情报系统的有机组成部分,科学管理与利用体育图书资料工作是提高高校体育教学科研的有效保障。     

汤普森“文化唯物主义”的理论与范式

作为理论的"文化唯物主义"是汤普森在探索马克思主义英国化过程中,基于自己对斯大林主义的批判反思和历史研究实践,形成的一种主要适用于自由资本主义时代的历史唯物主义学说。作为范式的"文化唯物主义"是奠基在"自下而上"的观察视角、"人民历史"观念和超越资本主义的乌托邦议程这三个支撑点上的,它具有两种基本作用:真实的经验整体的倾听和再创造;大众文化的社会功能的分析与评价。     

论世界三大宗教与地理环境的关系

宗教是一种重要的社会文化现象,宗教地理学是人文地理学的重要分支之一.本文从佛教、基督教、伊斯兰教的起源、传播及信仰差异三个方面,对世界三大宗教与地理环境的关系作了初步的探讨.     

普通高校体育选项课程改革研究

针对广大学生对体育项目的爱好的差别,普通高校开设体育选项课已经势在必行.体育选项课中项目该如何设置,教师知识应如何更新,教学主管部门又该如何配合?这些都是实际工作中应切实解决的问题.     

Saving behaviour and earnings uncertainty: Evidence from the British Household Panel Survey

For the first time, this paper uses a panel data set, the British Household Panel Survey, to analyse saving behaviour in Britain. One objective is to test the precautionary saving hypothesis, according to which households save to self-insure against uncertainty. Our results show that in accordance with this hypothesis, various measures of uncertainty based on earnings variability have a statistically significant effect on households' saving decisions. Moreover, in accordance with the life cycle model, households save more if they expect their financial situation to deteriorate. Received: 15 June 1999/Accepted: 4 January 2001     

青海厄鲁特蒙古与清朝之早期关系述略

清定鼎之初 ,因忙于镇压中原地区的各种反抗势力 ,对于西陲各地只能采取安抚稳定的策略 ,即羁縻政策。清康熙帝之时 ,则逐步加强了对青海地区的统治和管辖 ,将青海诸部纳入中央势力范围之内。     

Enabling robust assessment of QTc prolongation in early phase clinical trials

Since the implementation of the International Conference on Harmonization (ICH) E14 guideline in 2005, regulators have required a “thorough QTc” (TQT) study for evaluating the effects of investigational drugs on delayed cardiac repolarization as manifested by a prolonged QTc interval. However, TQT studies have increasingly been viewed unfavorably because of their low cost effectiveness. Several researchers have noted that a robust drug concentration‐QTc (conc‐QTc) modeling assessment in early phase development should, in most cases, obviate the need for a subsequent TQT study. In December 2015, ICH released an “E14 Q&As (R3)” document supporting the use of conc‐QTc modeling for regulatory decisions. In this article, we propose a simple improvement of two popular conc‐QTc assessment methods for typical first‐in‐human crossover‐like single ascending dose clinical pharmacology trials. The improvement is achieved, in part, by leveraging routinely encountered (and expected) intrasubject correlation patterns encountered in such trials. A real example involving a single ascending dose and corresponding TQT trial, along with results from a simulation study, illustrate the strong performance of the proposed method. The improved conc‐QTc assessment will further enable highly reliable go/no‐go decisions in early phase clinical development and deliver results that support subsequent TQT study waivers by regulators.     

Some alternative bivariate Kumaraswamy models

In this article we discuss various strategies for constructing bivariate Kumaraswamy distributions. As alternatives to the Nadarajah et al. (2011) bivariate model, four different models are introduced utilizing a conditional specification approach, a conditional survival function approach, and an Arnold–Ng bivariate beta distribution construction approach. Distributional properties for such bivariate distributions are investigated. Parameter estimation strategies for the models are discussed, as are the consequences of fitting two of the models to a particular data set involving the proportion of foggy days at two different airports in Colombia.     

Feminism and science in Masters of Sex

This article examines the fictional characterization of the real-life sex researchers and scientists William H. Masters and Virginia E. Johnson in the Showtime television program Masters of Sex (2013–2016). The historical Johnson had a complicated relationship with second-wave feminism: she disdained the movement and was interested primarily in improving heterosexual marriages and the sex lives of married couples. The Johnson character speaks in a language of postfeminism with minimal interest in collective action and broader social change. However, second-wave feminists later used her and Masters’ research in order to support their own beliefs about sexual autonomy and freedom, within and beyond marriage and heterosexuality. The television program demonstrates Johnson’s importance to both phases of her and Masters’ research—in the first phase, when they are based in a hospital and university environment, and in the second, when they establish their own research institute and raise funds directly from the clients that they serve. Johnson exemplifies postfeminist depictions of ambitious women in prestige television, her aim to have a successful career and marriage conflict, and while she is willing to compromise scientific values to serve her own goals, her male colleagues temper that ambition in service of “objective” science.