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91.
92.
The main goal of phase I cancer clinical trials is to determine the highest dose of a new therapy associated with an acceptable level of toxicity for the use in a subsequent phase II trial. The continual reassessment method (CRM) [O’Quigley, J., Pepe, M., Fisher, L., 1990. Continual reassessment method: a practical design for phase I clinical trials in cancer. Biometrics 46, 33–48] and escalation with overdose control (EWOC) [Babb, J., Rogatko, A., Zacks, S., 1998. Cancer phase I clinical trials: efficient dose escalation with overdose control. Statist. Med. 17 (10), 1103–1120] are two model-based designs used for phase I cancer clinical trials. A few modifications of the (original) CRM and EWOC have been made by many authors. In this paper, we show how CRM and EWOC can be unified and present a hybrid design. We study the characteristics of the approach of the hybrid design. The comparisons of the three designs (CRM, EWOC, and the hybrid design) are presented by convergence rates and overdose proportions. The simulation results show that the hybrid design generally has faster convergence rates than EWOC and smaller overdose proportions than CRM, especially when the true maximum tolerated dose (MTD) is above the mid-level of the dose range considered. The performance of these three designs is also evaluated in terms of sensitivity to outliers. 相似文献
93.
In this paper we discuss constructing confidence intervals based on asymptotic generalized pivotal quantities (AGPQs). An AGPQ associates a distribution with the corresponding parameter, and then an asymptotically correct confidence interval can be derived directly from this distribution like Bayesian or fiducial interval estimates. We provide two general procedures for constructing AGPQs. We also present several examples to show that AGPQs can yield new confidence intervals with better finite-sample behaviors than traditional methods. 相似文献
94.
Cornwell, Schmidt, and Sickles (1990) and Kumbhakar (1990), among others, developed stochasticfrontier production models which allow firm specific inefficiency levels to change over time. These studies assumed arbitrary restrictions on the short-run dynamics of efficiency levels which have little theoretical justification. Further, the models are inappropriate for estimation of long-run efficiencies. We consider estimation of an alternative frontier model in which firmspecific technical inefficiency levels are autoregressive. This model is particularly useful to examine a potential dynamic link between technical innovations and production inefficiency levels. We apply our methodology to a panel of US airlines. 相似文献
95.
Edwin Choi & Peter Hall 《Journal of the Royal Statistical Society. Series B, Statistical methodology》2000,62(2):461-477
Given a linear time series, e.g. an autoregression of infinite order, we may construct a finite order approximation and use that as the basis for confidence regions. The sieve or autoregressive bootstrap, as this method is often called, is generally seen as a competitor with the better-understood block bootstrap approach. However, in the present paper we argue that, for linear time series, the sieve bootstrap has significantly better performance than blocking methods and offers a wider range of opportunities. In particular, since it does not corrupt second-order properties then it may be used in a double-bootstrap form, with the second bootstrap application being employed to calibrate a basic percentile method confidence interval. This approach confers second-order accuracy without the need to estimate variance. That offers substantial benefits, since variances of statistics based on time series can be difficult to estimate reliably, and—partly because of the relatively small amount of information contained in a dependent process—are notorious for causing problems when used to Studentize. Other advantages of the sieve bootstrap include considerably greater robustness against variations in the choice of the tuning parameter, here equal to the autoregressive order, and the fact that, in contradistinction to the case of the block bootstrap, the percentile t version of the sieve bootstrap may be based on the 'raw' estimator of standard error. In the process of establishing these properties we show that the sieve bootstrap is second order correct. 相似文献
96.
Designing and integrating composite networks for monitoring multivariate gaussian pollution fields 总被引:2,自引:0,他引:2
J. V. Zidek W. Sun & N. D. Le 《Journal of the Royal Statistical Society. Series C, Applied statistics》2000,49(1):63-79
Networks of ambient monitoring stations are used to monitor environmental pollution fields such as those for acid rain and air pollution. Such stations provide regular measurements of pollutant concentrations. The networks are established for a variety of purposes at various times so often several stations measuring different subsets of pollutant concentrations can be found in compact geographical regions. The problem of statistically combining these disparate information sources into a single 'network' then arises. Capitalizing on the efficiencies so achieved can then lead to the secondary problem of extending this network. The subject of this paper is a set of 31 air pollution monitoring stations in southern Ontario. Each of these regularly measures a particular subset of ionic sulphate, sulphite, nitrite and ozone. However, this subset varies from station to station. For example only two stations measure all four. Some measure just one. We describe a Bayesian framework for integrating the measurements of these stations to yield a spatial predictive distribution for unmonitored sites and unmeasured concentrations at existing stations. Furthermore we show how this network can be extended by using an entropy maximization criterion. The methods assume that the multivariate response field being measured has a joint Gaussian distribution conditional on its mean and covariance function. A conjugate prior is used for these parameters, some of its hyperparameters being fitted empirically. 相似文献
97.
In this paper we consider the problem of estimating a coefficient of a strongly elliptic partial differential operator in stochastic parabolic equations. The coefficient is a bounded function of time. We compute the maximum likelihood estimate of the function on an approximating space (sieve) using a finite number of the spatial Fourier coefficients of the solution and establish conditions that guarantee consistency and asymptotic normality of the resulting estimate as the number of the coefficients increases. The equation is assumed diagonalizable in the sense that all the operators have a common system of eigenfunctions. 相似文献
98.
陈益民 《浙江树人大学学报》2001,1(2):75-79
本文对数学中化归的方法含义,化归的方法要素和核心作了一些理论探索,提出了化归的三条基本途径:(1)向基本模型化归;(2)向特殊模型化归;(3)向低层模型化归。并对化归方法作了教学实践尝试,从熟悉化、简单化、直观化入手提出了化归是一种重要的解决问题的方法。 相似文献
99.
戴震《孟子字义疏证》采用经学训诂的形式对义理内容进行建构,在学术思想史上产生了巨大影响。本文对戴震的义理旨趣、考据特征以及对《孟子》的创新阐释及其缺陷作了分析,认为其过度目的性阐释导致了《疏证》在接受方面的诸多困局。戴震义理学表面上对程朱理学持批判立场,但双方在动机、旨趣和义理内容的建构上不具同源性,戴震把程朱理学瑕疵当成程朱理学本身加以攻击,对原始儒意的理解并没有超越宋儒而进行。戴震对于《孟子》的把握仍有未达,但《疏证》所展现出来的批判精神却影响深远。 相似文献
100.
王意 《河北工程大学学报(社会科学版)》2008,25(2):110-111
大学物理课堂上很少作演示实验,课容量大,内容抽象,根据这一特点,大学物理课堂上的提问就有其自身的特点。课堂提问在整个教学环节中有着极其重要的作用,提问的方式方法不同,产生的效果往往会发生根本的变化。因此,课堂提问应该注意提问的对象、提问的范围、提问的多样性、提问的针对性等等问题。 相似文献