γ-氨基丁酸、青霉素和苯巴比妥钠对小鼠痛阈的影响

脑室注射外源性GABA可明显提高小鼠痛阈,其作用呈剂量一效应依赖关系。苯巴比妥钠通过抑制GABA摄取、激活GABA受体或GABA摹拟效应使痛阈显著升高,GABA与其呈协同作用;而青霉素通过抑制GABA摄取及竞争GABA受体对痛阈产生先上升后下降的双向效应,GABA与其呈拮抗作用。提示脑中GABA系统可能参与痛觉调制,其机制可能与脑中GABA含量无直接关系,而与GABA的突触过程密切相关。     

Quark b2型运动心肺功能测试系统应用研究

研究目的:通过对Quark b2型运动心肺功能测试系统应用过程中相关问题的探讨,促进同行对运动心肺功能测试的深入认识以及对测试精度的更准确掌握。研究方法:对作者近年使用该型号仪器的经验进行总结并与国内外有关专家学者的研究报道进行印证比较,从中探索其内在的规律。研究结果:对本型号仪器的使用规程及其注意事项提出了相应的意见;对测试方案进行了综合比较,给出了相应的意见;对测试流程中最大摄氧量和无氧阈的判断标准给予了相应的建议;对测试指标的后期分析提出了自己的意见。研究结论:运动心肺功能测试是一项能综合反映人体心肺功能水平的有效测试技术,在逐步探索如何能够有效增加测试精度和效果的基础上,应该逐步推广该项测试技术。     

Social network,Biden approval,and pediatric COVID-19 vaccine uptake

This study aims to estimate the pediatric COVID-19 vaccine uptake and the impact of social network and Biden approval. A national survey was conducted by Qualtrics from September 26 to 19 October 2022, and respondents who identified as primary guardians of children under 18 are included in this study. Findings show that parents are more likely to vaccinate children between 12 and 17 than children between 5 and 11 or below 5. The means of measures for social network and Biden approval for parents who have vaccinated children across different age groups are significantly higher than the corresponding means for parents whose children remain unvaccinated. Structural equation modeling results suggest the social network and Biden approval positively affect parents' decision to vaccinate children. The former predictor also mediates the latter on the outcome measure. The findings are significant when analyzing the sample of parents with children over five. These findings contribute to the literature and have policy implications for leveraging interventions and optimizing vaccination for children.