Dirichlet Processes in Nonlinear Mixed Effects Models

In this article, we use two efficient approaches to deal with the difficulty in computing the intractable integrals when implementing Gibbs sampling in the nonlinear mixed effects model (NLMM) based on Dirichlet processes (DP). In the first approach, we compute the Laplace's approximation to the integral for its high accuracy, low cost, and ease of implementation. The second approach uses the no-gaps algorithm of MacEachern and Müller (1998 MacEachern , S. , Müller , P. ( 1998 ). Estimating mixtures of Dirichlet process models . Journal of Computational and Graphical Statistics 7 : 223 – 238 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) to perform Gibbs sampling without evaluating the difficult integral. We apply both approaches to real problems and simulations. Results show that both approaches perform well in density estimation and prediction and are superior to the parametric analysis in that they can detect important model features, such as skewness, long tails, and multimodality, whereas the parametric analysis cannot.     

An algorithm for the minimum sum of weighted absolute errors regression

We propose an algorithm to estimate the unknown constants in a multiple linear regression model under the minimum sum of weighted absolute errors (MSWAE). The proposed algorithm, a generalization of an earlier algorithm, is compared to a bounded variable algorithm. Some somputational experience is reported.     

A Unified Way to Represent and Compute the Cumulative Distribution Function for Noncentral t,F, and χ2

This short article shows an unified approach to representing and computing the cumulative distribution function for noncentral t, F, and χ². Unlike the existing algorithms, which involve different expansion and/or recurrence, the new approach consistently represents all the three noncentral cumulative distribution functions as the integral of the normal cumulative distribution function and χ² density function.     

An EM algorithm for the estimation of parameters of bivariate generalized exponential distribution under random left censoring

In this paper, we consider the four-parameter bivariate generalized exponential distribution proposed by Kundu and Gupta [Bivariate generalized exponential distribution, J. Multivariate Anal. 100 (2009), pp. 581–593] and propose an expectation–maximization algorithm to find the maximum-likelihood estimators of the four parameters under random left censoring. A numerical experiment is carried out to discuss the properties of the estimators obtained iteratively.     

Estimation of a discriminant function from a mixture of two inverse Weibull distributions

The classification of a random variable based on a mixture can be meaningfully discussed only if the class of all finite mixtures is identifiable. In this paper, we find the maximum-likelihood estimates of the parameters of the mixture of two inverse Weibull distributions by using classified and unclassified observations. Next, we estimate the nonlinear discriminant function of the underlying model. Also, we calculate the total probabilities of misclassification as well as the percentage bias. In addition, we investigate the performance of all results through a series of simulation experiments by means of relative efficiencies. Finally, we analyse some simulated and real data sets through the findings of the paper.     

A Method of Finding Predictor Genes for a Particular Disease Using a Clustering Algorithm

Clustering Algorithms are nowadays really important tools in microarray data analysis. The different clustering algorithm generally used in biological science does not take into consideration the underlying probability distribution of the data. In this sense, they are heuristic in nature. In this work we proposed a clustering algorithm based on EM Algorithm. It gives 28% less misclassification than the K-means algorithm (which is mostly use in Bio science). We have also shown on a real data set that this algorithm can be efficiently used for detecting the genes which are responsible for a particular disease.     

A network algorithm for the exact treatment of the 2×k contingency table

A common statistical problem encountered in biomedical research is to test the hypothesis that the parameters of k binomial populations are all equal. An exact test of significance of this hypothesis is possible in principle, the appropriate null distribution being a normalized product of k binomial coefficients. However, the problem of computing the tail area of this distribution can be formidable since it requires the enumeration of all sets of k binomial coefficients whose product is less than a given constant. Existing algorithms, all of which rely on explicit enumeration to generate feasible binomial coefficients     

Issues in blinded sample size re-estimation

The utility of blinded sample size re-estimation for clinical trials depends on the ability to estimate variability without providing information about the true treatment difference, and on some reasonable assurance that the method is not likely to cause the sample size to be increased when the treatment effect is better than anticipated. We show that violations of these properties are unlikely to occur in practice.     

Nonparametric maximum likelihood estimation for artificially truncated absence data

In manpower planning it is cornmoniy tue case tnat employees withuraw from active service for a period of time before returning to take up post at a later date. Such periods of absence are frequently of major concern to employers who are anxious to ensure that employees return as soon as possible. The distribution of duration of such periods of absence are therefore of considerable interest as is the probability that such employees will ever return to active service. In this paper we derive a nonparametric estimator for such a lifetime distribution based on renewal data which are subject to various forms of incompleteness, namely right censoring, left and right truncation, and forward recurrence. Artificial truncation is used to ensure that the data are time homogeneous. A nonparametric maximum likelihood estimator for the lifetime.     

The robust economic statistical design of the Hotelling's T2 chart

ABSTRACT

Economic statistical designs aim at minimizing the cost of process monitoring when a specific scenario or a set of estimated process and cost parameters is given. But, in practice the process may be affected by more than one scenario which may lead to severe cost penalties if the wrong design is used. Here, we investigate the robust economic statistical design (RESD) of the T² chart in an attempt to reduce these cost penalties when there are multiple scenarios. Our method is to employ the genetic algorithm (GA) optimization method to minimize the total expected monitoring cost across all distinct scenarios. We illustrate the effectiveness of the method using two numerical examples. Simulation studies indicate that robust economic statistical designs should be encouraged in practice.