铜在维持机体运动能力中的重要作用

阐述了铜在造血、抗氧化、抗自由基损伤等方面的功能及机理,分析了铜与人体运动能力的关系,得出结论:适量补铜可以提高机体的有氧代谢能力和抗运动性损伤的能力,从而最终提高运动能力.     

某场哺乳仔猪暴发猪瘟的诊断与扑灭报告

本文报导了某猪场30～50日龄哺乳仔猪暴发猪瘟的流行情况、症状、病理变化以及实验室诊断结果。进行紧急免疫接种后迅速地控制了疫情。改进了该场原来的仔猪猪瘟免疫程序并取得了满意的效果,建议在生产中采用这一免疫程序。     

Confidence bands for the Michaelis-Menten kinetic model

The maximization and minimization procedure for constructing confidence bands for the general nonlinear regression model is explained. Then, using the maximization and minimization procedure, a conservative confidence band for the Michaelis-Menten kinetic model used in enzyme kinetics is constructed.     

Evaluating the Potential for a Helicobacter pylori Drinking Water Guideline

Helicobacter pylori is a microaerophilic, gram‐negative bacterium that is linked to adverse health effects including ulcers and gastrointestinal cancers. The goal of this analysis is to develop the necessary inputs for a quantitative microbial risk assessment (QMRA) needed to develop a potential guideline for drinking water at the point of ingestion (e.g., a maximum contaminant level, or MCL) that would be protective of human health to an acceptable level of risk while considering sources of uncertainty. Using infection and gastric cancer as two discrete endpoints, and calculating dose‐response relationships from experimental data on humans and monkeys, we perform both a forward and reverse risk assessment to determine the risk from current reported surface water concentrations of H. pylori and an acceptable concentration of H. pylori at the point of ingestion. This approach represents a synthesis of available information on human exposure to H. pylori via drinking water. A lifetime risk of cancer model suggests that a MCL be set at <1 organism/L given a 5‐log removal treatment because we cannot exclude the possibility that current levels of H. pylori in environmental source waters pose a potential public health risk. Research gaps include pathogen occurrence in source and finished water, treatment removal rates, and determination of H. pylori risks from other water sources such as groundwater and recreational water.     

Simultaneous confidence bands for nonlinear regression models

The maximization and minimization procedure for constructing confidence bands about general regression models is explained. Then, using an existing confidence region about the parameters of a nonlinear regression model and the maximization and minimization procedure, a generally conservative simultaneous confidence band is constructed about the model. Two examples are given, and some problems with the procedure are discussed     

脑肽对胃酸分泌的调节作用

许多报道已经指出,某些脑肽在中枢起作用影响胃酸的分泌。下丘脑,尤其是室旁核、延髓核,包括迷走背复核、疑核、中缝苍白球核、中缝隐核以及脊髓是脑肽调节胃酸分泌的重要作风部位。脑肽的中枢作用通过植物性神经系统的特殊通路被传送到胃,但这些通路有种族和肽的特异性。脑肽改变胃酸分泌的外周机制不受胃泌素的调节,而涉及乙酰胆硷、组织胺、5-羟色胺、前列腺素等物质释放的改变。脑肽显示为一类重要的胃酸分泌的脑调节剂,並对解释脑-肠相互作用的机制是极为有用的。     

幽门螺杆菌cag致病岛基因与胃部相关疾病关系的研究

采用特异性引物,使用PE公司生产的9600型PCR仪分别扩增了临床分离的66株幽门螺杆菌(Helicobactorpylori)的cagA的298bp片段、cag致病岛的cag 中的170bp和cag 中的597bp片段,对H.pylori中cag致病岛各片段的存在状况与胃部相关疾病的关系进行了探讨.结果表明,cagA,cag ,cag 在胃炎、消化性溃疡和胃癌三组疾病间的检出差异无显著性(p>0.05).cag致病岛的完整状态在上述疾病中差异显著(p<0.05).说明cagA,cag ,cag 的存在或缺失与疾病的相关性并不显著;cag致病岛的完整状态与疾病的类型相关,且随疾病严重程度的增大其完整性降低.     

紫杉醇脂质体联合顺铂、氟尿嘧啶一线治疗晚期胃癌的临床观察

目的观察紫杉醇脂质体联合顺铂、氟尿嘧啶（PCF方案）一线治疗晚期胃癌的临床疗效和毒副反应。方法选择晚期胃癌患者静点紫杉醇脂质体175mg／m^2,第一天静滴90min;顺铂75mg／m^2,第一天静滴;亚叶酸钙400mg／m^2,第一天静点2h;氟尿嘧啶2．6g／m^2,亚叶酸钙滴注结束后立即持续泵入46h。21天为一个周期,每2个周期按RE—SIST标准评价疗效,所有患者至少接受2周期化疗。结果28例患者中总有效率RR49．9％,完全缓解3．57％,稳定25％,中位进展时间（TTP）6．8个月,中位生存时间10．8个月。常见的不良反应为血液学毒性,恶心呕吐,肌肉酸痛,疲乏,脱发。结论紫杉醇脂质体联合顺铂、氟尿嘧啶（PCF方案）一线治疗晚期胃癌疗效确切,不良反应轻,值得临床推广应用。     

小麦细胞质雄性不育系过氧化物酶活性的研究

测定了小麦细胞质雄性不育系不同发育时期过氧化物酶活性 ,结果表示 :在花药败育之前 ,不育系叶片、花药过氧化物酶活性与保持系无明显差异 ;在花药败育之后 ,不育系花药过氧化物酶活性则明显高出保持系 .花药过氧化物酶活性的显著提高可能是导致小麦细胞质雄性不育的原因之一 .     

超细内镜对胃癌早期发现的临床意义探讨

目的 探讨超细内镜对胃癌早期发现的临床意义.方法 采用FUJINON EG-270N5前视式超细内镜观察60例胃癌患者胃癌发生部位和病变性质,对比内镜和病理活检结果.结果 进展期胃癌53例,与超细内镜的诊断符合率为96.4％;早期胃癌7例,与超细内镜的诊断符合率为71.2％,提示超细内镜对胃癌组织形态变化和病程进展情况的诊断结果与活检诊断结果符合率较高.结论 临床使用超细内镜结合活检组织检查,可有效早期发现胃癌的发病部位和病变性质.