Modeling the Adenoma and Serrated Pathway to Colorectal CAncer (ASCCA)

Several colorectal cancer (CRC) screening models have been developed describing the progression of adenomas to CRC. Currently, there is increasing evidence that serrated lesions can also develop into CRC. It is not clear whether screening tests have the same test characteristics for serrated lesions as for adenomas, but lower sensitivities have been suggested. Models that ignore this type of colorectal lesions may provide overly optimistic predictions of the screen‐induced reduction in CRC incidence. To address this issue, we have developed the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) model that includes the adenoma‐carcinoma pathway and the serrated pathway to CRC as well as characteristics of colorectal lesions. The model structure and the calibration procedure are described in detail. Calibration resulted in 19 parameter sets for the adenoma‐carcinoma pathway and 13 for the serrated pathway that match the age‐ and sex‐specific adenoma and serrated lesion prevalence in the COlonoscopy versus COlonography Screening (COCOS) trial, Dutch CRC incidence and mortality rates, and a number of other intermediate outcomes concerning characteristics of colorectal lesions. As an example, we simulated outcomes for a biennial fecal immunochemical test screening program and a hypothetical one‐time colonoscopy screening program. Inclusion of the serrated pathway influenced the predicted effectiveness of screening when serrated lesions are associated with lower screening test sensitivity or when they are not removed. To our knowledge, this is the first model that explicitly includes the serrated pathway and characteristics of colorectal lesions. It is suitable for the evaluation of the (cost)effectiveness of potential screening strategies for CRC.     

美国视频通信市场的转型——付费视频内容转向互联网

本文概述了当前美国有线电视行业／付费视频行业的局势，以及一些重要问题和面临的挑战，展望了未来的视频市场，概述了一个未来视频／宽带市场的战略愿景，然后回归到政策建议及具体的立法和管制行动。这将帮助我们在最短的、可操作的时间内通向一个开放的、非歧视性的、无处不在的宽带网络。     

Policy Space: What,for What,and Where?

This article examines how developing countries can use, and enlarge, existing policy space, without opting out of international commitments. It argues that: (i) a meaningful context for policy space must extend beyond trade policy and include macroeconomic and exchange‐rate policies that will achieve developmental goals more effectively; (ii) policy space depends not only on international rules but also on the impact of international market conditions and policy decisions taken in other countries on the effectiveness of national policy instruments; and (iii) international integration affects policy space through several factors that pull in opposite directions; whether it increases or reduces policy space differs by country and type of integration.     

关于建立城乡统一的社会保障体系的浅见

建立城乡统一的社会保障体系不仅是学术界争论的焦点，也是实践部门讨论的热点。各种主张众说纷纭。然而，建立统一的社会保障体系不能凭空设想，应立足于实际，坚持具体问题具体分析。当务之急是根据农村的情况，分地方、分人群、分层次建立安全有效的农村社会保障体系。     

青藏高原地区与东部发达地区区域经济合作若干法律问题研究

本文以青藏高原地区与东部发达地区区域经济合作为切入点,以法治化为视角,对青藏高原地区经济一体化的必然性、法律特征以及青藏高原地区与东部发达地区区域经济合作的若干法律问题进行了初步探讨,并提出了相关法律对策建议。     

哈尼族研究中史误的三点辨正

国内有关哈尼族的研究近年来硕果累累,但有的论著中对某些史料的理解存在误区.本文以原始资料为依据,针对哈尼族研究中涉及到的<尚书·禹贡>记载与梯田的关系,明初黔西北、滇东北有无"和泥芒部府",康熙时参与反清起义的龙韬之地位与族属三个问题,进行了相关的考证分析,提出了不同于以往的看法.     

世界体系中的"华南经济圈"及其参与中国-东盟自由贸易区的优势问题--全球化背景下的华南经济圈研究之一

世界各地的华侨华人经济联系建构了世界华商网络 ,并以此融入世界体系 ,形成了整个“中华经济圈” ;而包括粤港澳台闽桂琼在内的“华南经济圈”则构筑了“中华经济圈”的圆心 ,并维系其经济增长 (“圆周半径”)的动态平衡。“华南经济圈”由闽台经济区、珠江三角洲经济区、环北部湾沿岸经济区和环南中国海经济区所构成 ,它参与中国———东盟自由贸易区的优势主要在于地缘经济优势、特区经济优势和会展经济优势     

试析青海社会经济发展现状与实现小康的差距

全面建设小康社会是“十六大”确定的重要目标。边远、落后的民族地区能否实现小康事关全局。本文就青海目前的发展现状和差距及如何实现民族地区的小康社会作了一些探讨。     

试论民族地区经济发展立法

民族地区的经济发展立法是社会主义市场经济法律体系的重要组成部分。本文通过阐述民族地区经济发展立法的价值取向、民族地区经济发展立法中存在的问题、以及如何完善民族地区经济发展立法的途径等方面,对民族地区经济发展立法进行了初步探讨     

古代新疆经济文化区的划分——兼论维吾尔族经济文化类型的演变

现代维吾尔族主要是一个农业民族,其经济文化类型属于绿洲灌溉农业。历史上维吾尔族曾经历了狩猎、游牧等经济模式,9世纪中叶以后,逐渐改变为定居的农业民族。在边疆地区全面建设小康社会进程中,民族地区的现代化发展道路选择应保持民族文化的传承性。