A Bayesian hierarchical model for categorical longitudinal data from a social survey of immigrants

Summary.  The paper investigates a Bayesian hierarchical model for the analysis of categorical longitudinal data from a large social survey of immigrants to Australia. Data for each subject are observed on three separate occasions, or waves, of the survey. One of the features of the data set is that observations for some variables are missing for at least one wave. A model for the employment status of immigrants is developed by introducing, at the first stage of a hierarchical model, a multinomial model for the response and then subsequent terms are introduced to explain wave and subject effects. To estimate the model, we use the Gibbs sampler, which allows missing data for both the response and the explanatory variables to be imputed at each iteration of the algorithm, given some appropriate prior distributions. After accounting for significant covariate effects in the model, results show that the relative probability of remaining unemployed diminished with time following arrival in Australia.     

A hierarchical modelling approach to analysing longitudinal data with drop-out and non-compliance, with application to an equivalence trial in paediatric acquired immune deficiency syndrome

Longitudinal clinical trials with long follow-up periods almost invariably suffer from a loss to follow-up and non-compliance with the assigned therapy. An example is protocol 128 of the AIDS Clinical Trials Group, a 5-year equivalency trial comparing reduced dose zidovudine with the standard dose for treatment of paediatric acquired immune deficiency syndrome patients. This study compared responses to treatment by using both clinical and cognitive outcomes. The cognitive outcomes are of particular interest because the effects of human immunodeficiency virus infection of the central nervous system can be more acute in children than in adults. We formulate and apply a Bayesian hierarchical model to estimate both the intent-to-treat effect and the average causal effect of reducing the prescribed dose of zidovudine by 50%. The intent-to-treat effect quantifies the causal effect of assigning the lower dose, whereas the average causal effect represents the causal effect of actually taking the lower dose. We adopt a potential outcomes framework where, for each individual, we assume the existence of a different potential outcomes process at each level of time spent on treatment. The joint distribution of the potential outcomes and the time spent on assigned treatment is formulated using a hierarchical model: the potential outcomes distribution is given at the first level, and dependence between the outcomes and time on treatment is specified at the second level by linking the time on treatment to subject-specific effects that characterize the potential outcomes processes. Several distributional and structural assumptions are used to identify the model from observed data, and these are described in detail. A detailed analysis of AIDS Clinical Trials Group protocol 128 is given; inference about both the intent-to-treat effect and average causal effect indicate a high probability of dose equivalence with respect to cognitive functioning.     

帕尔默文化语言学视阈下的《红高粱家族》意象英译探析--以葛浩文译本为例

帕尔默文化语言学是一种以意象为核心的文化语言理论。意象根植于文化,语言是意象的载体,因此,意象的解读与语言和文化有关。在意象英译的过程中,译者需要对其进行正确的解读,并尽可能地在译入语中寻找和原文对应或者相近的意象进行传达。文章以帕尔默文化语言学为视角,从语言和文化两个维度对《红高粱家族》意象英译进行分析,探讨意象缺失与误译的原因,试图为汉语文学意象英译提供相应启示。     

On empirical likelihood for linear models with missing responses

Suppose that we have a linear regression model Y=X^′β+_ν0(X)ε$Y=X^{\prime }\beta +{\nu }_0(X)\epsilon$ with random error ε$\epsilon$, where X is a random design variable and is observed completely, and Y is the response variable and some Y-values are missing at random (MAR). In this paper, based on the ‘complete’ data set for Y after inverse probability weighted imputation, we construct empirical likelihood statistics on EY   and β$\beta$ which have the χ²${\chi }^2$-type limiting distributions under some new conditions compared with Xue (2009). Our results broaden the applicable scope of the approach combined with Xue (2009).     

The Relative Effectiveness of Procedures Commonly Used in Multiple Regression Analysis for Dealing with Missing Values

Expressions are derived for the bias and variance associated with procedures frequently used to estimate partial regression coefficients in a linear model having the two explanatory variables x ₁ and x ₂, with missing values on x ₂ only. The expressions are used to help gain insight into the relative effectiveness of these procedures for handling more complex patterns of missing data.     

Predictive Influence of Unavailable Values of Future Explanatory Variables in a Linear Model

We consider an approach to prediction in linear model when values of the future explanatory variables are unavailable, we predict a future response y ^f at a future sample point x ^f when some components of x ^f are unavailable. We consider both the cases where x ^f are dependent and independent but normally distributed. A Taylor expansion is used to derive an approximation to the predictive density, and the influence of missing future explanatory variables (the loss or discrepancy) is assessed using the Kullback–Leibler measure of divergence. This discrepancy is compared in different scenarios including the situation where the missing variables are dropped entirely.     

Estimation in Partially Linear Single-Index Models with Missing Covariates

In this article, we consider a partially linear single-index model Y = g(Z ^τθ₀) + X ^τβ₀ + ? when the covariate X may be missing at random. We propose weighted estimators for the unknown parametric and nonparametric part by applying weighted estimating equations. We establish normality of the estimators of the parameters and asymptotic expansion for the estimator of the nonparametric part when the selection probabilities are unknown. Simulation studies are also conducted to illustrate the finite sample properties of these estimators.     

An Index of Local Sensitivity to Nonignorability for a Pseudolikelihood Method

For regression analysis of data with non response, sensitivity analysis is usually recommended. An index of local sensitivity to non ignorability (ISNI) (Troxel et al., 2004 Troxel , A. B. , Ma , G. , Heitjan , D. F. (2004). An index of local sensitivity to nonignorability. Statistica Sinica 14:1221–1237.[Web of Science ®] , [Google Scholar]) was derived to detect the sensitivity of maximum likelihood estimates to small departures from ignorability. However, ISNI requires specification of a parametric model for the missing-data mechanism. In this article, a local sensitivity index for a pseudolikelihood (PL) method that does not require specification of the mechanism is proposed. For bivariate data (x, y), when the non response mechanism is an arbitrary function of x + λy, this new index is defined as the first derivative of the PL estimate with respect to λ at λ = 0. The closed form was derived for normal regression data when the density function of the predictor x approximated by a kernel estimator in the PL method. The utility of this new local sensitivity index was illustrated through application on one dataset.     

Equivalence of maximum likelihood estimation and iterative two-stage estimation for seemingly unrelated regression models

The seemingly unrelated regression model is viewed in the context of repeated measures analysis. Regression parameters and the variance-covariance matrix of the seemingly unrelated regression model can be estimated by using two-stage Aitken estimation. The first stage is to obtain a consistent estimator of the variance-covariance matrix. The second stage uses this matrix to obtain the generalized least squares estimators of the regression parameters. The maximum likelihood (ML) estimators of the regression parameters can be obtained by performing the two-stage estimation iteratively. The iterative two-stage estimation procedure is shown to be equivalent to the EM algorithm (Dempster, Laird, and Rubin, 1977) proposed by Jennrich and Schluchter (1986) and Laird, Lange, and Stram (1987) for repeated measures data. The equivalence of the iterative two-stage estimator and the ML estimator has been previously demonstrated empirically in a Monte Carlo study by Kmenta and Gilbert (1968). It does not appear to be widely known that the two estimators are equivalent theoretically. This paper demonstrates this equivalence.     

A test of the missing data mechanism for repeated measures data

The occurrence of missing data is an often unavoidable consequence of repeated measures studies. Fortunately, multivariate general linear models such as growth curve models and linear mixed models with random effects have been well developed to analyze incomplete normally-distributed repeated measures data. Most statistical methods have assumed that the missing data occur at random. This assumption may include two types of missing data mechanism: missing completely at random (MCAR) and missing at random (MAR) in the sense of Rubin (1976). In this paper, we develop a test procedure for distinguishing these two types of missing data mechanism for incomplete normally-distributed repeated measures data. The proposed test is similar in spiril to the test of Park and Davis (1992). We derive the test for incomplete normally-distribrlted repeated measures data using linear mixed models. while Park and Davis (1992) cleirved thr test for incomplete repeatctl categorical data in the framework of Grizzle Starmer. and Koch (1969). Thr proposed procedure can be applied easily to any other multivariate general linear model which allow for missing data. The test is illustrated using the hip-replacernent patient.data from Crowder and Hand (1990).