The Times They are A’changing: Multigenerational Family Simulations

Multigenerational households are increasingly affecting both the individual and family as well as community organizations and social policies. Social work and other family studies students can profit from educational modalities that use adult learning applications through a systems life-course perspective, the whole family aging over time. Family simulation software—addressing multigenerational families, such as two or more adult generations living together—builds on a previous paper (Marriage & Family Review, Feb. 2015). Social class, among other demographic and environmental variables, is emphasized. Agent-based family social network simulation of multigenerational families can facilitate experiential learning. An automatically generated life events report, based on both factual data and specific family characteristics, can be used as a classroom case study for role playing and assessing.     

高校体育图书资料的管理与利用

高校体育图书资料是高校图书资料情报系统的有机组成部分,科学管理与利用体育图书资料工作是提高高校体育教学科研的有效保障。     

Saving behaviour and earnings uncertainty: Evidence from the British Household Panel Survey

For the first time, this paper uses a panel data set, the British Household Panel Survey, to analyse saving behaviour in Britain. One objective is to test the precautionary saving hypothesis, according to which households save to self-insure against uncertainty. Our results show that in accordance with this hypothesis, various measures of uncertainty based on earnings variability have a statistically significant effect on households' saving decisions. Moreover, in accordance with the life cycle model, households save more if they expect their financial situation to deteriorate. Received: 15 June 1999/Accepted: 4 January 2001     

青海厄鲁特蒙古与清朝之早期关系述略

清定鼎之初 ,因忙于镇压中原地区的各种反抗势力 ,对于西陲各地只能采取安抚稳定的策略 ,即羁縻政策。清康熙帝之时 ,则逐步加强了对青海地区的统治和管辖 ,将青海诸部纳入中央势力范围之内。     

Critically assessing digital documents: materiality and the interpretative role of software

As a contribution to the ongoing tradition of critically assessing documents for research, this paper aims to highlight materiality as a key factor in the co-shaping of knowledge derived from digital documents. The paper first builds upon prior debates in document studies with work from the fields of Science and Technology Studies, and Communication Studies, to establish the role of document materiality in the interpretative process. By first establishing digital documents’ material reality as electrical signal, the paper then discusses the interpretative role of software, in both the representation of that signal for human interpretation and the production of the document through software tools. Finally, the paper considers the implications for persistence and access to digital documents posed by their material reality and the private archival contexts in which they often reside.     

Enabling robust assessment of QTc prolongation in early phase clinical trials

Since the implementation of the International Conference on Harmonization (ICH) E14 guideline in 2005, regulators have required a “thorough QTc” (TQT) study for evaluating the effects of investigational drugs on delayed cardiac repolarization as manifested by a prolonged QTc interval. However, TQT studies have increasingly been viewed unfavorably because of their low cost effectiveness. Several researchers have noted that a robust drug concentration‐QTc (conc‐QTc) modeling assessment in early phase development should, in most cases, obviate the need for a subsequent TQT study. In December 2015, ICH released an “E14 Q&As (R3)” document supporting the use of conc‐QTc modeling for regulatory decisions. In this article, we propose a simple improvement of two popular conc‐QTc assessment methods for typical first‐in‐human crossover‐like single ascending dose clinical pharmacology trials. The improvement is achieved, in part, by leveraging routinely encountered (and expected) intrasubject correlation patterns encountered in such trials. A real example involving a single ascending dose and corresponding TQT trial, along with results from a simulation study, illustrate the strong performance of the proposed method. The improved conc‐QTc assessment will further enable highly reliable go/no‐go decisions in early phase clinical development and deliver results that support subsequent TQT study waivers by regulators.     

Some alternative bivariate Kumaraswamy models

In this article we discuss various strategies for constructing bivariate Kumaraswamy distributions. As alternatives to the Nadarajah et al. (2011) bivariate model, four different models are introduced utilizing a conditional specification approach, a conditional survival function approach, and an Arnold–Ng bivariate beta distribution construction approach. Distributional properties for such bivariate distributions are investigated. Parameter estimation strategies for the models are discussed, as are the consequences of fitting two of the models to a particular data set involving the proportion of foggy days at two different airports in Colombia.     

Feminism and science in Masters of Sex

This article examines the fictional characterization of the real-life sex researchers and scientists William H. Masters and Virginia E. Johnson in the Showtime television program Masters of Sex (2013–2016). The historical Johnson had a complicated relationship with second-wave feminism: she disdained the movement and was interested primarily in improving heterosexual marriages and the sex lives of married couples. The Johnson character speaks in a language of postfeminism with minimal interest in collective action and broader social change. However, second-wave feminists later used her and Masters’ research in order to support their own beliefs about sexual autonomy and freedom, within and beyond marriage and heterosexuality. The television program demonstrates Johnson’s importance to both phases of her and Masters’ research—in the first phase, when they are based in a hospital and university environment, and in the second, when they establish their own research institute and raise funds directly from the clients that they serve. Johnson exemplifies postfeminist depictions of ambitious women in prestige television, her aim to have a successful career and marriage conflict, and while she is willing to compromise scientific values to serve her own goals, her male colleagues temper that ambition in service of “objective” science.     

Researcher reflexivity: exploring the impacts of CAQDAS use

Computer-assisted qualitative data analysis software (CAQDAS) programs are established tools for qualitative research. Making informed decisions when using them requires researchers to understand how they affect research practices and outcomes. In this article we consider the impact of CAQDAS on researcher reflexivity. Reviewing three decades of literature, we identify specific ‘reflexive moments’ experienced by CAQDAS users, the contexts in which they occur, the issues they raise, and the reflexive awareness they generate. The ways in which CAQDAS can enhance or undermine researcher reflexivity are also reported. By doing so, we aim to help researchers and especially research students (and their supervisors) understand the relationship between CAQDAS and reflexivity and the reflexive moments they may encounter when using such software.     

Gender-specific differences in labor market adjustment patterns: Evidence from the United States

Do men and women behave differently while adjusting labor supply over the business cycle? Using data from the United States, we show that women are significantly more likely to adjust along the intensive margin (number of hours), while men adjust more along the extensive margin (employment). Older, single, and divorced/widowed adjust predominantly along the extensive margin.