More flexible sequential and non-sequential designs in long-term clinical trial

In this paper, we describe decision making procedures as they exist in most clinical trials,review some recently suggested approaches to monitoring and clarify how these methods allow greater flexibility in monitoring and explicit specification of data monitoring methods in the protocol.     

Nonparametric estimation of the survival distribution in censored data

Two nonparametric estimators o f the survival distributionare discussed. The estimators were proposed by Kaplan and Meier (1958) and Breslow (1972) and are applicable when dealing with censored data. It is known that they are asymptotically unbiased and uniformly strongly consistent, and when properly normalized that they converge weakly to the same Gaussian process. In this paper, the properties of the estimators are carefully inspected in small or moderate samples. The Breslow estimator, a shrinkage version of the Kaplan-Meier, nearly always has the smaller mean square error (MSE) whenever the truesurvival probabilityis at least 0.20, but has considerably larger MSE than the Kaplan-Meier estimator when the survivalprobability is near zero.     

Asymptotic Results of a Nonparametric Conditional Quantile Estimator for Functional Time Series

We consider the estimation of the conditional quantile function when the covariates take values in some abstract function space. The main goal of this article is to establish the almost complete convergence and the asymptotic normality of the kernel estimator of the conditional quantile under the α-mixing assumption and on the concentration properties on small balls of the probability measure of the functional regressors. Some applications and particular cases are studied. This approach can be applied in time series analysis to the prediction and building of confidence bands. We illustrate our methodology with El Niño data.     

A Multiple Imputation Approach to the Analysis of Current Status Data with the Additive Hazards Model

This article discusses regression analysis of current status data, which occur in many fields including cross-sectional studies, demographical investigations, and tumorigenicity experiments (Keiding, 1991 Keiding , N. ( 1991 ). Age-specific incidence and prevalence: a statistical perspective (with discussion) . J. Roy. Statist. Soc. Ser. A 154 : 371 – 412 .[Crossref] , [Google Scholar]; Sun 2006 Sun , J. ( 2006 ). The Statistical Analysis of Interval-Censored Failure Time Data . New York : Springer-Verlag . [Google Scholar]). For the problem, we focus on the situation where the survival time of interest can be described by the additive hazards model and a multiple imputation approach is presented for inference. A major advantage of the approach is its simplicity and it can be easily implemented by using the existing software packages for right-censored failure time data. Extensive simulation studies are conducted and indicate that the approach performs well for practical situations and is comparable to the existing methods. The methodology is applied to a set of current status data arising from a tumorigenicity experiment and the model checking is discussed.     

Bivariate short distributions

The method of MML estimation for a univariate normal (Tiku 1967, 1973) is extended to a bivariate normal population. Thus, a theoretical foundation is given to the robust correlation coefficient proposed by Tiku and Balakrishnan (1986).     

Comparing mean ranks for repeated measures data

Rank tests are considered that compare t treatments in repeated measures designs. A statistic is given that contains as special cases several that have been proposed for this problem, including one that corresponds to the randomized block ANOVA statistic applied to the rank transformed data. Another statistic is proposed, having a null distribution holding under more general conditions, that is the rank transform of the Hotelling statistic for repeated measures. A statistic of this type is also given for data that are ordered categorical rather than fully rankedo Unlike the Friedman statistic, the statistics discussed in this article utilize a single ranking of the entire sample. Power calculations for an underlying normal distribution indicate that the rank transformed ANOVA test can be substantially more powerful than the Friedman test.     

An approximation for analyzing a broad class of implicitly and explicitly defined estimators

An approximation is presented that can be used to gain insight into the characteristics – such as outlier sensitivity, bias, and variability – of a wide class of estimators, including maximum likelihood and least squares. The approximation relies on a convenient form for an arbitrary order Taylor expansion in a multivariate setting. The implicit function theorem can be used to construct the expansion when the estimator is not defined in closed form. We present several finite-sample and asymptotic properties of such Taylor expansions, which are useful in characterizing the difference between the estimator and the expansion.     

MODELING THE LIFETIME OF LONGITUDINAL ELEMENTS

In the study of the stochastic behaviour of the lifetime of an element as a function of its length, it is often observed that the failure time (or lifetime) decreases as the length increases. In probabilistic terms, such an idea can be expressed as follows. Let T be the lifetime of a specimen of length x, so the survival function, which denotes the probability that an element of length x survives till time t, will be given by S_T (t, x) = P(T > t/α(x), where α(x) is a monotonically decreasing function. In particular, it is often assumed that T has a Weibull distribution. In this paper, we propose a generalization of this Weibull model by assuming that the distribution of T is Generalized gamma (GG). Since the GG model contains the Weibull, Gamma and Lognormal models as special and limiting cases, a GG regression model is an appropriate tool for describing the size effect on the lifetime and for selecting among the embedded models. Maximum likelihood estimates are obtained for the GG regression model with α(x) = cx^b . As a special case this provide an alternative to the usual approach to estimation for the GG distribution which involves reparametrization. Related parametric inference issues are addressed and illustrated using two experimental data sets. Some discussion of censored data is also provided.     

HAZARD RATE ESTIMATION FOR CENSORED DATA BY WAVELET METHODS

ABSTRACT

We study the estimation of a hazard rate function based on censored data by non-linear wavelet method. We provide an asymptotic formula for the mean integrated squared error (MISE) of nonlinear wavelet-based hazard rate estimators under randomly censored data. We show this MISE formula, when the underlying hazard rate function and censoring distribution function are only piecewise smooth, has the same expansion as analogous kernel estimators, a feature not available for the kernel estimators. In addition, we establish an asymptotic normality of the nonlinear wavelet estimator.     

Estimation of the location and scale parameters of the extreme value distmbution based on multiply type-II censored samples

In this paper, we consider the problem of estimating the location and scale parameters of an extreme value distribution based on multiply Type-II censored samples. We first describe the best linear unbiased estimators and the maximum likelihood estimators of these parameters. After observing that the best linear unbiased estimators need the construction of some tables for its coefficients and that the maximum likelihood estimators do not exist in an explicit algebraic form and hence need to be found by numerical methods, we develop approximate maximum likelihood estimators by appropriately approximating the likelihood equations. In addition to being simple explicit estimators, these estimators turn out to be nearly as efficient as the best linear unbiased estimators and the maximum likelihood estimators. Next, we derive the asymptotic variances and covariance of these estimators in terms of the first two single moments and the product moments of order statistics from the standard extreme value distribution. Finally, we present an example in order to illustrate all the methods of estimation of parameters discussed in this paper.