An inclusion-consistent solution to the problem of absurd confidence statements: 2. Consistent nonexact-confidence-interval estimation

Two consistent nonexact-confidence-interval estimation methods, both derived from the consistency-equivalence theorem in Plante (1991), are suggested for estimation of problematic parametric functions with no consistent exact solution and for which standard optimal confidence procedures are inadequate or even absurd, i.e., can provide confidence statements with a 95% empty or all-inclusive confidence set. A belt C(·) from a consistent nonexact-belt family, used with two confidence coefficients (γ = inf_θ P_θ [ θ ? C(X)] and γ⁺ = sup_θ P_θ[θ ? C(X)], is shown to provide a consistent nonexact-belt solution for estimating μ₂ -μ₁ in the Behrens-Fisher problem. A rule for consistent behaviour enables any confidence belt to be used consistently by providing each sample point with best upper and lower confidence levels [δ⁺(x) ≥ γ⁺, δ(x) ≤ γ], which give least-conservative consistent confidence statements ranging from practically exact through informative to noninformative. The rule also provides a consistency correction L(x) = δ⁺(x)-δ(X) enabling alternative confidence solutions to be compared on grounds of adequacy; this is demonstrated by comparing consistent conservative sample-point-wise solutions with inconsistent standard solutions for estimating μ₂/μ₁ (Creasy-Fieller-Neyman problem) and $\sqrt {\mu _1^2 + \mu _2^2 }$, a distance-estimation problem closely related to Stein's 1959 example     

Exact Statistical Tests for Heterogeneity of Frequencies Based on Extreme Values

Sophisticated statistical analyses of incidence frequencies are often required for various epidemiologic and biomedical applications. Among the most commonly applied methods is the Pearson's χ² test, which is structured to detect non specific anomalous patterns of frequencies and is useful for testing the significance for incidence heterogeneity. However, the Pearson's χ² test is not efficient for assessing the significance of frequency in a particular cell (or class) to be attributed to chance alone. We recently developed statistical tests for detecting temporal anomalies of disease cases based on maximum and minimum frequencies; these tests are actually designed to test of significance for a particular high or low frequency. The purpose of this article is to demonstrate merits of these tests in epidemiologic and biomedical studies. We show that our proposed methods are more sensitive and powerful for testing extreme cell counts than is the Pearson's χ² test. This feature could provide important and valuable information in epidemiologic or biomeidcal studies. We elucidated and illustrated the differences in sensitivity among our tests and the Pearson's χ² test by analyzing a data set of Langerhans cell histiocytosis cases and its hypothetical sets. We also computed and compared the statistical power of these methods using various sets of cell numbers and alternative frequencies. The investigation of statistical sensitivity and power presented in this work will provide investigators with useful guidelines for selecting the appropriate tests for their studies.