The time‐dependent “cure‐death” model investigating two equally important endpoints simultaneously in trials treating high‐risk patients with resistant pathogens

A variety of primary endpoints are used in clinical trials treating patients with severe infectious diseases, and existing guidelines do not provide a consistent recommendation. We propose to study simultaneously two primary endpoints, cure and death, in a comprehensive multistate cure‐death model as starting point for a treatment comparison. This technique enables us to study the temporal dynamic of the patient‐relevant probability to be cured and alive. We describe and compare traditional and innovative methods suitable for a treatment comparison based on this model. Traditional analyses using risk differences focus on one prespecified timepoint only. A restricted logrank‐based test of treatment effect is sensitive to ordered categories of responses and integrates information on duration of response. The pseudo‐value regression provides a direct regression model for examination of treatment effect via difference in transition probabilities. Applied to a topical real data example and simulation scenarios, we demonstrate advantages and limitations and provide an insight into how these methods can handle different kinds of treatment imbalances. The cure‐death model provides a suitable framework to gain a better understanding of how a new treatment influences the time‐dynamic cure and death process. This might help the future planning of randomised clinical trials, sample size calculations, and data analyses.     

All for one or one for all? Authorship and the cross-sectoral valuation of credit in nutrition science

The passionate pursuit of authorships is fuelled by the value they represent to scholars and scientists. This article asks how this value differs across scientists and how these different processes of valuation inform authorship articulation, strategies, and publication behavior in general. Drawing from a qualitative analysis of authorship practices among nutrition scientists employed at universities, contract research organizations, and in food industry, I argue that two different modi operandi emerge when it comes to authorship. These different ways of working produce different collaborative approaches, different credit distribution strategies amongst collaborators, and different value placed upon (the pursuit of) authorship. These different valuation processes are neither explicit nor recognizable to those reading (and judging) author lists. As a consequence, in the politics of authorship, the names standing atop a scientific publication in nutrition science represent different types of value to both the individuals and employing organizations.     

诸神之争的再阐释:一个社会学的结构视角

世俗化及逆世俗化范式的对立其实蕴含着更大的连续性,即如何理解宗教多元主义背后的诸神之争,总的来说,韦伯之后那些解释宗教变迁的理论范式均未突破韦伯对宗教的比较研究范畴,难以在当前复杂而多元的文化环境下为个人提供总体指导,但是二者共同揭露了诸神之争条件下西方宗教工具理性和价值理性交互作用所促成的理性化的动力机制,即西方宗教维护自身价值理性的方式从中世纪教会主导的政治性垄断过渡到现代性条件下宗教多元主义的市场化竞争。     

A social welfare perspective of market‐oriented social enterprises

The article analyses market‐oriented social enterprises from a social welfare perspective, within the context of the innate conflict between business and welfare orientations. After defining the concept of market‐oriented social enterprises and presenting some successful examples on such entities that employ different marginalised populations, particularly people with disabilities, the article asks three interrelated questions: (i) What policy environment is needed to encourage the development of social enterprises? (ii) Given the innate tension between the social and economic objectives in social enterprises, what structural principles are needed to enable them to meet those dual objectives? Lastly, (iii) What intervention modalities are best suited to help individual participants in those frameworks? Answers to these questions are discussed within conceptual frameworks from the worlds of welfare and business that jointly provide a base for a social welfare rationale for market‐oriented social enterprises.     

Monitoring the parameter vector of regression models with time-to-event response in phase II processes

In most of the existing specialized literature, monitoring regression models are a special case of profile monitoring. However, not every regression model always represents appropriately a profile data structure. This is clearly the case of the Weibull regression model (WRM) with common shape parameter γ. Even though it might be thought that existing methodologies (especially likelihood-ratio (LRT)-based methods) for monitoring generalized linear profiles can also be successfully applied to monitoring regression models with time-to-event response, it will be shown in this paper that those methodologies work fairly acceptable just for data structures with 1000 observations at least approximately. It was found out that some corrections, often referred to as Bartlett's adjustments, are needed to be implemented in order to improve the accuracy of using the asymptotic distributional properties of the LRT statistic for carrying out the monitoring of WRM with relatively small and moderate dimensions of the available datasets. Simulation studies suggest that the use of the aforementioned corrections make the resulting charts work quite acceptable when available data structures contain 30 observations at least. Detection abilities of the proposed schemes improve as dataset dimension increases.     

Objective Bayesian analysis based on upper record values from two-parameter Rayleigh distribution with partial information

In the life test, predicting higher failure times than the largest failure time of the observed is an important issue. Although the Rayleigh distribution is a suitable model for analyzing the lifetime of components that age rapidly over time because its failure rate function is an increasing linear function of time, the inference for a two-parameter Rayleigh distribution based on upper record values has not been addressed from the Bayesian perspective. This paper provides Bayesian analysis methods by proposing a noninformative prior distribution to analyze survival data, using a two-parameter Rayleigh distribution based on record values. In addition, we provide a pivotal quantity and an algorithm based on the pivotal quantity to predict the behavior of future survival records. We show that the proposed method is superior to the frequentist counterpart in terms of the mean-squared error and bias through Monte carlo simulations. For illustrative purposes, survival data on lung cancer patients are analyzed, and it is proved that the proposed model can be a good alternative when prior information is not given.     

Asymptotic expansions of density of normalized extremes from logarithmic general error distribution

Logarithmic general error distribution is an extension of the log-normal distribution. In this paper, the asymptotic expansions of densities of normalized maximum from logarithmic general error distribution are derived under two different kinds of normalized constants. By applying the main results, the higher-order expansions of moments of maxima are established.     

A formative evaluation of the recovery public works programme in Blantyre City,Malawi

Public works programmes (PWPs) are popular social protection instruments in the context of chronic poverty but very little has been published in the way of implementation and outcomes of these programmes. This paper presents a formative process and outcome evaluation of the recovery PWP in Blantyre City, Malawi. The evaluation used longitudinal household survey data of PWP beneficiaries, programme records and interview responses from programme staff and community leaders. Largely, the process evaluation findings showed an agreement between actual and planned activities. The outcome evaluation found indications that the PWP community assets offered some potential benefits to the communities, and that PWP wages allowed the beneficiaries to purchase some food. This however, did not translate into more meals per day, nor did the earnings prevent the decline in household assets as expected. Given a plausible PWP theory and high implementation fidelity, the PWP wage rate or number of days was either just enough to smooth participant income, or insufficient altogether, to enable achievement of more distal outcomes.     

The Chinese Cashmere Industry: A Global Value Chain Analysis

Growth and internationalisation of the Chinese economy have reconfigured the global value chains of many commodities with important implications for industry and rural and regional development both in and outside China. This article analyses the chain for cashmere, all stages of which have gravitated to China, and the impacts on rural development, especially for herders in remote pastoral regions. Traditionally a high‐value product, cashmere has become increasingly generic and adulterated over the past decade. More formal and closer integration of Chinese actors into the global industry and re‐orienting policy from supply‐side intervention to the enforcement of standards would enhance the competitiveness of Chinese cashmere in international fibre markets.     

职业本位与以人为本对比研究

职业教育是以人为本还是以职业为本,是关于职业教育价值观的讨论。这种价值观,决定了职业教育的目的及其本真追求。正是基于此,探讨两种观念下的不同教育才有意义有价值,才能给现代职业教育发展提供借鉴。